DNA-encoded library (DEL): A new method for drug screening
Accelerating the early stages of research! A kit for DNA-encoded libraries (DEL) that enables compound screening using NGS.
As an efficient compound screening method, DNA-encoded libraries (DEL) have been established as a common technique in drug discovery settings. At Sigma-Aldrich, we have simplified DEL into an easy-to-use kit with the cooperation of DyNAbind, a company with unique dynamic library technology, to ensure that many researchers can widely utilize DEL technology. After progressing with screening according to the prepared experimental protocol, it is possible to obtain structural information of high-binding fragment compounds as a result through NGS analysis. <Sigma-Aldrich DEL Kit Features> ■ Affordable and easy access to the noteworthy DEL technology ■ A large compound library covering a wide chemical space ■ Provides more reliable results than conventional DELs due to unique dynamic library technology ■ Available for purchase as a catalog item without the need for licensing agreements *For more details, please refer to the PDF document or feel free to contact us.
basic information
**DyNAbind DEL Workflow** ■Screen - Bind fragment compounds to immobilized target proteins ■Sequence - Perform dimer ligation - Amplify the bound compounds with a unique tag using PCR - Analyze DNA sequences with NGS ■Identify - Confirm hit compounds from DNA sequences at SigmaAldrich.com/DELanalysis <Product Information> - DYNA001-1EA | DyNAbind(R) DNA-Encoded Fragment Library https://www.sigmaaldrich.com/JP/ja/product/sial/dyna001?context=product - DYNA002-1EA | DyNAbind(R) 10 Million Compound DNA-Encoded Library 【NEW】 https://www.sigmaaldrich.com/JP/ja/product/sial/dyna002?context=product
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Applications/Examples of results
For more details, please refer to the PDF document or feel free to contact us.
