LV Centramate Tangential Flow Filtration System
Scalable from lab scale up to a maximum of 4 L! Designed to maximize product recovery rate.
The "LV Centramate" is a product designed for the scale-up and scale-down of tangential flow filtration process development, small batch production of biopharmaceutical processes, scale-down testing, and the production of materials for safety and efficiency studies (Phase I clinical trials). With a low residual volume, it achieves high concentration factors from a small starting volume. Since it has the same flow path length as the Centramate cassette holder and Centrasette cassette holder, linear scale-up is possible. In a 2010 study, LV Centramate was used for the concentration of AAV viruses purified from cell culture supernatant [1]. 【Features】 ■ Linear scale-up is possible ■ Can also be used in conjunction with other lab TFF systems ■ Achieves high concentration factors from a small starting volume due to low residual volume ■ Easy connection with SUS316L polished luer lock ports, ensuring the same compatibility characteristics as the production scale Centrasette holder [1] Vandenberghe, et al., Human Gene Therapy. 21. 1251-1257 (2010).
basic information
【Other Features】 ■ Designed for scale-up and scale-down of tangential flow filtration (TFF) process development, small batch production of biopharmaceutical processes, scale-down testing, and production of materials for safety studies and efficiency studies (Phase I clinical). ■ Has the same flow path length as Centramate cassette holders and Centrasette cassette holders. ■ The LV Centramate holder can also be used in conjunction with other lab TFF systems to enhance scalability characteristics. ■ Scalable to production scale and optimized for processing typical usage amounts during development and new drug discovery phases. *For more details, please refer to the PDF materials or feel free to contact us.
Price range
Delivery Time
Model number/Brand name
LV Centramate
Applications/Examples of results
【Applications】 ■ Concentration of biomolecules ■ Recovery and purification of biomolecules from cell culture supernatants and lysates ■ Diafiltration, desalting, and buffer exchange of biomolecules ■ Fractionation of mixed molecular solutions *For more details, please refer to the PDF document or feel free to contact us.
