Capto Q chromatography resin
Ion exchange resins for initial and intermediate purification at process scale
Capto Q increases particle rigidity while maintaining pore size, which is essential for binding capacity at process scale. By coating agarose resin with dextran surface extender, it achieves a high dynamic binding capacity. ● Reduces process time with high binding capacity, high flow rate, and low delivery pressure ● Enables purification at high bed heights with rigid agarose resin ● Allows purification of viscous samples under high flow rate conditions Additionally, separation of AAV full/empty can be achieved through ion exchange chromatography. ● Purification of Full Capsids with a purity of 95-100% ● Improved selectivity with Capto Q's Dextran Extender ● Reduced selectivity with resin lacking Dextran Extender ● Improved selectivity for Full/Empty due to optimized buffer
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