Quantitative Phase Imaging (QPI) Microscope
Non-invasive live cell imaging - Zero-staining quantitative phase imaging "Q-Phase"
The Q-Phase by Telight is a quantitative phase imaging (QPI) microscope that employs patented Coherence Controlled Holographic (CCHD) technology. It measures and visualizes the dry mass and morphological changes of cells in real-time while minimizing phototoxicity and allowing for label-free imaging. This platform innovates long-term live cell analysis across pharmaceutical research, regenerative medicine, and mechanobiology. Typical applications include: - Drug discovery screening: Rapid assessment of cell proliferation inhibition and cytotoxicity based on dry mass changes after compound treatment. - Cancer research: Analysis of migration and invasion, as well as tracking EMT dynamics. - Immune cell analysis: Non-invasive monitoring of cell-cell interactions in co-culture systems. - Regenerative medicine / stem cells: Quantitative evaluation of morphological and mass shifts during differentiation induction. - Mechanobiology: High-contrast observation of 3D cultured cells within Matrigel or collagen matrices.
basic information
Specifications: - Magnification: 4× to 60× - Lateral resolution: 0.58 µm (at 60× NA1.4) - Phase sensitivity: 0.011 rad - Frame rate: Up to 16 fps (expandable depending on specifications) - Stage top incubator: Complete with temperature, CO₂, and humidity control range
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Model number/Brand name
Telight Corporation Q-Phase
Applications/Examples of results
Representative applications: - Drug discovery screening: Rapid assessment of cell proliferation inhibition and cytotoxicity after compound treatment using dry mass changes. - Cancer research: Analysis of migration and invasion, and tracking of EMT dynamics. - Immune cell analysis: Non-invasive monitoring of cell-to-cell interactions in co-culture systems. - Regenerative medicine / stem cells: Quantitative evaluation of morphological and mass shifts during differentiation induction. - Mechanobiology: High-contrast observation of 3D cultured cells within Matrigel or collagen matrices.
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Physio-Machina Co., Ltd. is a company that primarily sells products such as formulation development equipment and dissolution testers, conducts validation and calibration of peripheral devices, and engages in the import and export of software and various equipment. Additionally, it actively provides translation and interpretation of technical documents and seminars, as well as support for the creation of SOPs and conducts training sessions.