Standard for measuring particle size and concentration of exosomes.

International standard for measuring particle size and concentration of exosomes/microvesicles.

NanoSight allows for real-time observation of the Brownian motion of nanoparticles in liquid on a PC screen using NTA (Nanoparticle Tracking Analysis) technology. Recently, in exosome research, NanoSight has provided new insights by detecting exosomes and counting particle numbers through its unique features and technology. ■ Adoption of unique measurement technology "Nanoparticle Tracking Analysis (NTA)" A proprietary measurement method from NanoSight that calculates particle size based on the Brownian motion of each particle. ■ Measurement of individual nanoparticles/exosomes Instead of using averaged particle sizes obtained from fluctuations in scattered light intensity, it measures and displays the size of individual particles. ■ Visual observation of particle scattered light Real-time observation of the Brownian motion of nanoparticles in liquid on a PC screen is possible. ■ No need for refractive index or reflectivity information Samples with unknown surface property data, such as newly developed materials, surface coatings, and biomaterials, can be measured accurately.

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■Application Example: Detection and Counting of Exosomes NanoSight can accurately measure the size and concentration of exosomes/microvesicles. Additionally, by using fluorescent labels such as quantum dots, it is possible to selectively detect and analyze specific particles from a bulk sample. It can also be used to examine the degree of cell purification. Research on biological nanoparticles has been limited due to a lack of appropriate characterization methods, but NanoSight's unique features and technology are leading to new insights. The "Nanoparticle Tracking Analysis (NTA)" method employed by NanoSight visualizes exosomes/microvesicles (50–1000nm), counts them in real-time, and measures particle size distribution profiles and concentrations. Thus, the NTA technology is an attractive device compared to existing methods due to its simplicity, speed, high precision, and low cost.