[Data] Integrated simulation software for bio and antibody drug discovery.
Integrated software for diverse biologics and antibody drug discovery, including monoclonal antibodies, vaccine antigens, enzymes, and peptides.
Schrödinger's biologics and antibody drug discovery tools contribute to shortening development times through advanced simulations of various biologics. As an example, the following features are available: - Experimental value prediction and analysis using protein structure modeling - High-precision prediction techniques using FEP calculations *For more details, please feel free to contact us.
basic information
BioLuminate Our protein structure modeling technology allows for: 1. Prediction of structures of similar proteins, 2. Protein engineering functions such as a. aggregation prediction, b. hotspot identification, c. residue analysis, 3. Antibody modeling functions including a. CDR prediction from amino acid sequences, b. loop prediction, c. humanization, d. antigen-antibody docking simulation, 4. Protein-protein interaction analysis functions such as a. docking analysis, b. prediction of affinity changes due to residue mutations, c. alanine scanning, and other features. Protein FEP+ The energy analysis technology primarily based on free energy perturbation methods enables the calculation of high-precision predictions when applied to protein residues. Furthermore, by combining it with our BioLuminate, it allows for a comprehensive tool for a wide range of simulations in biology. #Biology #Modeling #Simulation #Prediction #Structure #Antibody #SmallMolecule #DrugDiscovery
Price information
For more details, please feel free to contact us.
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Applications/Examples of results
For more details, please refer to the PDF document or feel free to contact us.
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December 1 (Friday) to December 3 (Wednesday) - Participation and presentation at the 2nd Japanese Antibody Society Academic Conference
Schrödinger, Inc. will be exhibiting at the 2nd Annual Meeting of the Japanese Society for Antibody Research. Venue: Laika Nankoku Hall (Kagoshima) Dates: December 1 (Friday) - 3 (Sunday) 【Oral Presentation】 Date and Time: December 3 (Sunday) 15:10 - 15:35 Title: The Role and Impact of Computational Modeling in the Design and Development of Antibody-based Therapeutics Presenter: Eliud Oloo, Schrödinger, Inc. 【Poster Presentation】 Date and Time: December 2 (Saturday) 18:20 - 19:10 Title: Physics-based antibody analysis and design: Modeling of antigen-antibody complexes with disordered epitopes/very long CDR-H3 loops Presenter: Shuu Ichihara (Schrödinger, Inc.)
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We will be exhibiting at the 23rd Annual Meeting of the Japanese Society for Protein Science from July 5 (Wednesday) to July 7 (Friday).
Schrödinger, Inc. will be exhibiting at the 23rd Annual Meeting of the Japanese Society for Protein Science. Utilizing computational chemistry techniques based on the first principles of physics, which are employed by major pharmaceutical companies worldwide, we enable advanced drug design based on protein structural information. - Antibody 3D modeling using the integrated solution "BioLuminate" for biologics and antibody drug discovery - Prediction of antigen-antibody complex structures using protein-protein docking - Affinity and stability predictions using Free Energy Perturbation (FEP) methods Additionally, we will hold a luncheon seminar on Thursday, July 6, starting at 11:50. 【Luncheon Seminar Date and Location】 Date: Thursday, July 6, 11:50 - 12:40 Venue: 3rd Floor, Room C 【Program】 Schrödinger's approach to physics-based antibody analysis and design: dealing with disordered epitopes and very long CDR H3 loop Shu Ichihara (Schrödinger, Inc.)
