An assay method that correlates ion channel currents with neuronal excitability in hiPSC-derived dementia neurons is introduced.

Human induced pluripotent stem cells (hiPSCs) are a highly versatile platform for modeling human neurons, enabling the generation of excitatory neurons for in vitro models. To understand the electrophysiological properties of neurons, such as excitability and synaptic transmission, recording ion channels in hiPSC-derived neurons is key. Researchers can investigate healthy neurophysiological functions by capturing the dynamics of ion channel currents, such as sodium, potassium, and calcium, as well as explore dysfunctions related to neurological disorders like epilepsy, autism, and neurodegenerative diseases. These models provide valuable tools for studying disease mechanisms and testing potential therapeutic interventions in patient-specific contexts. *For more details, please refer to the related links. Feel free to contact us for more information.*

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