Application Report <High-Throughput APC Record>
High-throughput APC recordings of hippocampal neurons highlight their promise in improving treatment for cognitive dysfunction, mental illness, and schizophrenia.
A PhD from the University of Copenhagen has made significant progress by using the Qube 384 automated patch clamp (APC) platform to record α5-containing GABAA receptors from acutely isolated primary neurons. This research highlights the importance of using natural primary hippocampal neurons to evaluate the effects of antipsychotic drugs on GABAergic activity, particularly from the perspective of drug discovery for cognitive function and schizophrenia. Previous studies relied on heterologous expression systems, such as HEK cells expressing α5-containing GABAA receptors. However, this research emphasizes the value of investigating these effects in primary hippocampal neurons, which more accurately reflect physiological conditions. *For more details, please refer to the related links. Feel free to contact us for further information.*
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Sophion Bioscience was founded by a passionate group of electrophysiologists with a common goal of providing objective patch clamp results quickly and accurately, independent of the experimenter's skill. We have grown from a small startup in Denmark to a global company, but our passion and commitment to providing high-performance patch clamp solutions remain unchanged. Through exceptional technical service and application support, we back our customers in achieving their goals. Additionally, with the continuous development of the QPatch and Qube platforms, we ensure uncompromising data quality in a user-friendly environment, from assay setup to data analysis.