[Case Study] Impurity Analysis of Topiramate by HPLC-CAD
The combination of a single quadrupole mass spectrometer and CAD allows for the identification of known impurities and the prediction of molecular weights and proposed structures of unknown impurities!
This content explains the benefits of combining a Charged Aerosol Detector (CAD) and a Single Quadrupole Mass Spectrometer for impurity analysis of topiramate. The HPLC-UV system is a common analytical method used in many laboratories. By combining CAD and a mass spectrometer with this system, comprehensive impurity detection becomes possible. CAD detects non-volatile and semi-volatile compounds with high sensitivity. The mass spectrometer not only confirms molecular weight but also eliminates the possibility of co-elution by verifying peak purity. Additionally, the in-source Collision-Induced Dissociation (CID) function allows for the confirmation of known impurities and the structural estimation of unknown impurities. 【Features】 ■ Identification of known impurities and molecular weight prediction and structural estimation of unknown impurities ■ High-precision impurity profiling through combination with a Single Quadrupole Mass Spectrometer ■ Peak identification based on m/z and elimination of co-elution possibilities ■ CAD has high sensitivity and a wide dynamic range, accommodating gradient analysis *For more details, please download the PDF or feel free to contact us.
basic information
【System Configuration】 Thermo Scientific Vanquish Core HPLC System - Pump: Thermo Scientific Vanquish Quaternary Pump CN - Autosampler: Thermo Scientific Vanquish Split Sampler CT - Column Oven: Thermo Scientific Vanquish Column Compartment C - Detector: Thermo Scientific Vanquish CAD F Thermo Scientific ISQ EM Single Quadrupole Mass Spectrometer Software - Thermo Scientific Chromeleon Chromatography Data System 7.3 - Thermo Scientific Mass Frontier Software 8.1
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For more details, please download the PDF or feel free to contact us. It can only be used for research purposes and cannot be used for diagnostic purposes.
