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TOC Analyzer for the Pharmaceutical Industry - Sievers M9

Rapid / Easy / Accurate TOC Measurement

The Sievers M9 can accommodate a variety of applications due to its unique gas-permeable membrane conductivity measurement method and wide measurement range (0.03 ppb to 50 ppm). Features of the Sievers M9: - No carrier gas required - Stability in ultra-low concentration range - 12 months of calibration stability - Three models to choose from based on application (laboratory type/portable type/online type) - Compliance with data integrity requirements based on 21 CFR Part 11 (optional) - The sample conductivity measurement function allows simultaneous measurement of TOC and conductivity (USP<645> Stage 1) (optional) - An auto-sampler can automatically analyze up to 63 samples (40mL) (optional)

Related Link - https://aqua-ckc.jp/products/toc_m9

basic information

- Total Organic Carbon (TOC) Measurement Principle: Wet UV oxidation + gas permeable membrane conductivity measurement method Measurement Range: 0.03 ppb to 50 ppm TOC Accuracy: ±2% or 0.5 ppb, whichever is greater Reproducibility: RSD less than 1% Display Digits: 3 digits Calibration Frequency: Recommended every 12 months Measurement Interval: 2 minutes Interfering Substances: Not affected by coexisting ions other than organic substances - Equipment Power Requirements: 100–240 V, 50/60 Hz, 100 VA Ambient Temperature: 5–40 °C Humidity: Up to 95% without condensation Dimensions: Varies by model Weight: Varies by model (9.8 kg to 16.2 kg) *For detailed specifications, please refer to the catalog.

Price range

Delivery Time

Model number/Brand name

Sievers M9

Applications/Examples of results

- Measurement of pharmaceutical water - Cleaning validation - TOC analysis of leachables in USP<661> (Plastic Packaging Systems and Their Components)

Detailed information

Related Videos

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Model number overview
SPRD77110-01 TOC Meter M9 Laboratory Type
SPRD77115-01 TOC Meter M9 Laboratory Type (with Conductivity Measurement Function)
SPRD77210-01 TOC Meter M9 Portable Type
SPRD77215-01 TOC Meter M9 Portable Type (with Conductivity Measurement Function)
SPRD77310-01 TOC Meter M9 Online Type

catalog(48)

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TOC meter for cleaning validation

PRODUCT

Pharmaceutical Water/Cleaning Validation Sievers M9 Laboratory Type

PRODUCT

Sievers TOC Measurement Data Management Software DataShare Elite Software

PRODUCT

Comparison of TOC measurements in the cleaning validation of protein samples.

APPLICATION_NOTE

Sievers solutions for pharmaceutical applications

APPLICATION_NOTE

Commercially available low-concentration conductivity standard solution.

APPLICATION_NOTE

Swab TOC recovery rate of the compound in the worst-case scenario (feasibility test)

APPLICATION_NOTE

Real-time release through online cleaning validation using total organic carbon, inorganic carbon, and conductivity data.

APPLICATION_NOTE

TOC recovery rate of complex compounds: cleaning agents

APPLICATION_NOTE

Comparison of TOC Cleaning Validation Swab Kits.

APPLICATION_NOTE

TOC measurement of 0.2M sodium hydroxide using the Sievers M9 type.

APPLICATION_NOTE

TOC measurement of 0.2M potassium hydroxide using the Sievers M9 type.

APPLICATION_NOTE

Simultaneous measurement of TOC and conductivity to analyze non-conductive organic substances in cleaning agents.

APPLICATION_NOTE

TOC recovery rate using STERIS Life Sciences' cleaning agent_Sievers M9 type

APPLICATION_NOTE

Validation of TOC Method for Cleaning Validation in the Pharmaceutical Industry

APPLICATION_NOTE

Calculation of Maximum Allowable Carryover (MAC) in Cleaning Validation

APPLICATION_NOTE

Sievers Validation Support Package for Cleaning Validation

TECHNICAL

PAT Application: At-line TOC measurement for cleaning validation and product changeover.

APPLICATION_NOTE

Reduction of cleaning validation and product changeover costs by 92% through in-line TOC measurement.

APPLICATION_NOTE

Cleaning validation: Verifying the performance of the cleaning process.

APPLICATION_NOTE

Evaluation of the validity of cleaning standards based on engineering capability index

APPLICATION_NOTE

Analysis method for cleaning validation

APPLICATION_NOTE

Detection of TOC and conductivity of CIP-100 using the Sievers M series.

APPLICATION_NOTE

TOC recovery rate of insoluble and difficult-to-decompose compounds

APPLICATION_NOTE

Cost comparison of TOC and HPLC (using TOC analyzers for cleaning validation)

APPLICATION_NOTE

Sievers M9 type used for lab_atline_online_cleaning_validation

APPLICATION_NOTE

Real-time low-flow cleaning efficacy evaluation of pharmaceuticals using TOC and conductivity.

APPLICATION_NOTE

Cleaning evaluation: Microbial TOC recovery rate and linearity

APPLICATION_NOTE

Best Practices for Measuring Conductivity of Sievers M9 Type in Pharmaceutical Water

APPLICATION_NOTE

Measurement of conductivity and TOC using Sievers M9.

APPLICATION_NOTE

Sievers M9 Conductivity Measurement USP 645 Improvement of Stage 1 Robustness and Best Practices

APPLICATION_NOTE

TOC & Conductivity Sample Storage Container

APPLICATION_NOTE

Conductivity & TOC Sampling Standard Operating Procedure

MANUAL

Simultaneous measurement of TOC and conductivity for efficiency improvement and cost reduction.

APPLICATION_NOTE

Suitability of Conductivity Measurement for M9_EP Monograph_EP2.2.38_USP645

APPLICATION_NOTE

Simultaneous measurement of conductivity USP Stage 1 and TOC of pharmaceutical water in the lab.

APPLICATION_NOTE

Screening of USP 661.1 plastic packaging materials using the TOC meter Sievers M9 type.

APPLICATION_NOTE

TOC analysis of leachables in USP661 (Plastic Packaging Systems and Materials).

APPLICATION_NOTE

Conductivity Bridging Study: From Laboratory Conductivity Meter to Sievers M9 Type

APPLICATION_NOTE

Online TOC Analyzer Sievers M500

PRODUCT

Conductivity & TOC dual-use (DUCT) vial

PRODUCT

Performance and Stability of DUCT Vials

APPLICATION_NOTE

Five Tips for Successful Cleaning Validation

TECHNICAL

TOC Analyzer for Pharmaceuticals Sievers M9

PRODUCT

Cleaning Validation: Transition from HPLC to TOC - Three Factors to Consider

TECHNICAL

Sievers TOC Sensor CheckPoint Pharma

PRODUCT

Sievers Products Standard Solutions & Consumables Catalog

PRODUCT

Real-time test validation support package for pharmaceutical water.

APPLICATION_NOTE

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