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TOC Analyzer for the Pharmaceutical Industry - Sievers M9

Rapid / Easy / Accurate TOC Measurement

The Sievers M9 can accommodate a variety of applications due to its unique gas-permeable membrane conductivity measurement method and wide measurement range (0.03 ppb to 50 ppm). Features of the Sievers M9: - No carrier gas required - Stability in ultra-low concentration range - 12 months of calibration stability - Three models to choose from based on application (laboratory type/portable type/online type) - Compliance with data integrity requirements based on 21 CFR Part 11 (optional) - The sample conductivity measurement function allows simultaneous measurement of TOC and conductivity (USP<645> Stage 1) (optional) - An auto-sampler can automatically analyze up to 63 samples (40mL) (optional)

Related Link - https://aqua-ckc.jp/products/toc_m9

basic information

- Total Organic Carbon (TOC) Measurement Principle: Wet UV oxidation + gas permeable membrane conductivity measurement method Measurement Range: 0.03 ppb to 50 ppm TOC Accuracy: ±2% or 0.5 ppb, whichever is greater Reproducibility: RSD less than 1% Display Digits: 3 digits Calibration Frequency: Recommended every 12 months Measurement Interval: 2 minutes Interfering Substances: Not affected by coexisting ions other than organic substances - Equipment Power Requirements: 100–240 V, 50/60 Hz, 100 VA Ambient Temperature: 5–40 °C Humidity: Up to 95% without condensation Dimensions: Varies by model Weight: Varies by model (9.8 kg to 16.2 kg) *For detailed specifications, please refer to the catalog.

Price range

Delivery Time

Model number/Brand name

Sievers M9

Applications/Examples of results

- Measurement of pharmaceutical water - Cleaning validation - TOC analysis of leachables in USP<661> (Plastic Packaging Systems and Their Components)

Detailed information

Related Videos

Line up(5)

Model number overview
SPRD77110-01 TOC Meter M9 Laboratory Type
SPRD77115-01 TOC Meter M9 Laboratory Type (with Conductivity Measurement Function)
SPRD77210-01 TOC Meter M9 Portable Type
SPRD77215-01 TOC Meter M9 Portable Type (with Conductivity Measurement Function)
SPRD77310-01 TOC Meter M9 Online Type

catalog(47)

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TOC meter for cleaning validation

PRODUCT

Pharmaceutical Water/Cleaning Validation Sievers M9 Laboratory Type

PRODUCT

Comparison of TOC measurements in the cleaning validation of protein samples.

APPLICATION_NOTE

Sievers solutions for pharmaceutical applications

APPLICATION_NOTE

Commercially available low-concentration conductivity standard solution.

APPLICATION_NOTE

Swab TOC recovery rate of the compound in the worst-case scenario (feasibility test)

APPLICATION_NOTE

Real-time release through online cleaning validation using total organic carbon, inorganic carbon, and conductivity data.

APPLICATION_NOTE

TOC recovery rate of complex compounds: cleaning agents

APPLICATION_NOTE

Comparison of TOC Cleaning Validation Swab Kits.

APPLICATION_NOTE

TOC measurement of 0.2M sodium hydroxide using the Sievers M9 type.

APPLICATION_NOTE

TOC measurement of 0.2M potassium hydroxide using the Sievers M9 type.

APPLICATION_NOTE

Simultaneous measurement of TOC and conductivity to analyze non-conductive organic substances in cleaning agents.

APPLICATION_NOTE

TOC recovery rate using STERIS Life Sciences' cleaning agent_Sievers M9 type

APPLICATION_NOTE

Validation of TOC Method for Cleaning Validation in the Pharmaceutical Industry

APPLICATION_NOTE

Calculation of Maximum Allowable Carryover (MAC) in Cleaning Validation

APPLICATION_NOTE

Sievers Validation Support Package for Cleaning Validation

TECHNICAL

PAT Application: At-line TOC measurement for cleaning validation and product changeover.

APPLICATION_NOTE

Reduction of cleaning validation and product changeover costs by 92% through in-line TOC measurement.

APPLICATION_NOTE

Cleaning validation: Verifying the performance of the cleaning process.

APPLICATION_NOTE

Evaluation of the validity of cleaning standards based on engineering capability index

APPLICATION_NOTE

Analysis method for cleaning validation

APPLICATION_NOTE

Detection of TOC and conductivity of CIP-100 using the Sievers M series.

APPLICATION_NOTE

TOC recovery rate of insoluble and difficult-to-decompose compounds

APPLICATION_NOTE

Cost comparison of TOC and HPLC (using TOC analyzers for cleaning validation)

APPLICATION_NOTE

Sievers M9 type used for lab_atline_online_cleaning_validation

APPLICATION_NOTE

Real-time low-flow cleaning efficacy evaluation of pharmaceuticals using TOC and conductivity.

APPLICATION_NOTE

Cleaning evaluation: Microbial TOC recovery rate and linearity

APPLICATION_NOTE

Best Practices for Measuring Conductivity of Sievers M9 Type in Pharmaceutical Water

APPLICATION_NOTE

Measurement of conductivity and TOC using Sievers M9.

APPLICATION_NOTE

Sievers M9 Conductivity Measurement USP 645 Improvement of Stage 1 Robustness and Best Practices

APPLICATION_NOTE

TOC & Conductivity Sample Storage Container

APPLICATION_NOTE

Conductivity & TOC Sampling Standard Operating Procedure

MANUAL

Simultaneous measurement of TOC and conductivity for efficiency improvement and cost reduction.

APPLICATION_NOTE

Suitability of Conductivity Measurement for M9_EP Monograph_EP2.2.38_USP645

APPLICATION_NOTE

Simultaneous measurement of conductivity USP Stage 1 and TOC of pharmaceutical water in the lab.

APPLICATION_NOTE

Screening of USP 661.1 plastic packaging materials using the TOC meter Sievers M9 type.

APPLICATION_NOTE

TOC analysis of leachables in USP661 (Plastic Packaging Systems and Materials).

APPLICATION_NOTE

Conductivity Bridging Study: From Laboratory Conductivity Meter to Sievers M9 Type

APPLICATION_NOTE

Online TOC Analyzer Sievers M500

PRODUCT

Conductivity & TOC dual-use (DUCT) vial

PRODUCT

Performance and Stability of DUCT Vials

APPLICATION_NOTE

Five Tips for Successful Cleaning Validation

TECHNICAL

TOC Analyzer for Pharmaceuticals Sievers M9

PRODUCT

Cleaning Validation: Transition from HPLC to TOC - Three Factors to Consider

TECHNICAL

Sievers TOC Sensor CheckPoint Pharma

PRODUCT

Sievers Products Standard Solutions & Consumables Catalog

PRODUCT

Real-time test validation support package for pharmaceutical water.

APPLICATION_NOTE

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Since our establishment in 1967, we have been dedicated to the development and dissemination of water quality measurement devices that anyone can use quickly, easily, and with high precision. In today's world, where the effective use of water, a limited resource, is required alongside environmental conservation, we aim to be a total solution provider that responds to all water environments by utilizing our water quality measurement devices, technology, and services. Furthermore, leveraging the latest technology and years of know-how, we are committed to delivering user-friendly and reliable water quality measurement devices more affordably, quickly, and widely.