Comparison of TOC measurements in the cleaning validation of protein samples.
The Sievers TOC analyzer can measure protein samples with high accuracy.
In the pharmaceutical industry, cleaning validation is an essential process to ensure the quality and safety of products. In particular, accurately detecting residues of protein samples is crucial for guaranteeing the cleanliness of manufacturing equipment. TOC analyzers consist of a combination of oxidation methods and detection methods. - Oxidation Method of TOC Analyzers Commercially available TOC analyzers oxidize organic compounds to carbon dioxide using methods such as combustion oxidation or oxidants combined with ultraviolet oxidation. - Detection Method of TOC Analyzers To detect the concentration of carbon dioxide generated from the oxidation of organic compounds, non-dispersive infrared absorption (NDIR) methods and conductivity methods are commonly used. - Sievers Measurement Technology Sievers TOC analyzers employ a wet ultraviolet oxidation combined with gas-permeable membrane conductivity measurement method, allowing for high accuracy in measuring recovery rates even for protein samples, thus providing reliable data. This is expected to ensure product quality and safety and contribute to the overall reliability improvement in the industry.
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For details, please refer to the application note.
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Model number/Brand name
300_00117
Applications/Examples of results
Cleaning validation
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Since our establishment in 1967, we have been dedicated to the development and dissemination of water quality measurement devices that anyone can use quickly, easily, and with high precision. In today's world, where the effective use of water, a limited resource, is required alongside environmental conservation, we aim to be a total solution provider that responds to all water environments by utilizing our water quality measurement devices, technology, and services. Furthermore, leveraging the latest technology and years of know-how, we are committed to delivering user-friendly and reliable water quality measurement devices more affordably, quickly, and widely.