2. What is the crystallization sponge method?
A new structural analysis method that enables the determination of structures of trace and difficult-to-crystallize compounds.
In the structural analysis of organic molecules, there are challenges such as "small sample size," "inability to crystallize," and "unknown absolute configuration." The crystal sponge method is a technique that enables the determination of structures for trace samples and difficult-to-crystallize compounds by incorporating molecules into a crystal sponge to form a "pseudo single crystal." This explanation clearly outlines the differences from conventional analytical methods, as well as the features and application areas of the crystal sponge method. ▼Recommended for▼ - Those looking for new methods for structure determination - Those facing challenges in structural analysis of trace samples - Those unable to proceed with analysis due to lack of crystallization - Those considering the determination of absolute configuration - Researchers and developers in the fields of pharmaceuticals, chemicals, fragrances, and natural products *For more details, please download the PDF or feel free to contact us.*
basic information
■Principle of the Crystalline Sponge Method ■Main Challenges in Organic Molecular Structure Analysis ■Comparison with Conventional Methods (MS, NMR, Single Crystal X-ray Structure Analysis) ■Scope and Features of the Crystalline Sponge Method ■Positioning of the Crystalline Sponge Method in Structural Analysis ■Basic Flow to Structure Determination
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Applications/Examples of results
▼ Applications and Examples of Achievements ▼ - Confirmation of the structure of reaction products - Identification of by-products - Structural analysis of unknown components - Determination of the structure of impurities - Determination of absolute configuration - Support for intellectual property and patent acquisition - Identity verification in quality assurance, etc. ▼ Example Fields ▼ - Chemical manufacturers - Pharmaceutical manufacturers - Pesticide manufacturers - Fragrance manufacturers - Food manufacturers - Universities and research institutions - Contract analysis and evaluation departments, etc.
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Daicel utilizes structural analysis techniques, including the crystal sponge method, to provide new options for absolute configuration determination and structural determination. In general manufacturing and research and development settings, there are numerous challenges such as: - "The structure is too complex, and I am unsure if the estimated structure is correct using GC-MS or NMR." - "I cannot even estimate the structure because I can hardly obtain any quantity." - "I cannot perform single crystal X-ray structural analysis because I cannot crystallize it." At our center, by combining the crystal sponge method, single crystal X-ray structural analysis, and our unique structural analysis techniques, we offer optimal analytical approaches to structural determination challenges that are difficult with existing methods. Additionally, we possess dozens of unique crystal sponges and are working on applications to a wide range of compounds. We can also collaborate with column separation and purification services as needed, providing solutions that encompass everything from separation to structural determination.