In this study session, we will invite Professor Toshihiro Okuyama from Sophia University, who has been active on the front lines of journalism for many years as a former Asahi Shimbun reporter, and who continues to raise and explain social issues through the media, as well as actively participating in the hundred-member committee. He will provide an explanation of the Whistleblower Protection Act and responses to scandals, incorporating real examples. 【Event Overview】 ◆ Date and Time: November 1, 2024 (Friday) 16:00 - 17:00 ◆ Format: Free Webinar (A Zoom URL will be sent after registration) ◆ Tool Used: Zoom Webinars ◆ Participation Conditions: - Those using free email addresses, those from competing companies, and those whose affiliations are unclear are requested to refrain from registering. - When accessing Zoom on the day of the event, please enter the name and email address you provided at the time of registration in the Zoom participation input field.

【Event Overview】 In the Rare Disease Analysis Series, we will introduce the system overview and utilization methods of the paper exploration AI system "KIBIT Amanogawa," which can instantly detect papers, genes, and diseases that are highly similar or relevant to the words or sentences entered from a vast amount of paper information, focusing on the theme of target exploration for rare diseases. The theme for this session is "Pompe Disease." Pompe disease is one of the types of glycogen storage disease (GSD), specifically GSD type 2, caused by a deficiency of acid alpha-glucosidase. It presents symptoms such as muscle weakness and cardiomyopathy, and when it occurs in infancy, it can lead to very severe symptoms. In this seminar, we will demonstrate how to extract genes related to Pompe disease using paper exploration AI and formulate hypotheses for therapeutic targets, providing effective ways to utilize KIBIT Amanogawa to gain insights for research. 【Participation Conditions】 We kindly ask that individuals using free addresses, those from competing companies, and those whose affiliations are unclear refrain from applying. When accessing Zoom on the day of the event, please enter the name and email address you provided at the time of registration in the Zoom participation input field.

【Event Overview】 ◆Theme: Geopolitical Risks and Economic Security: Current Situation and Key Points for Corporate Response ◆Date and Time: November 6, 2024 (Wednesday) 16:30 - 17:30 ◆Platform: Zoom Webinars ◆Participation Requirements: Participants must be affiliated with a company. We kindly ask individuals, industry peers, and those using free email addresses to refrain from participating. ◆Content: The situation surrounding geopolitical risks and economic security is changing rapidly, making it an urgent management issue for companies to respond to. Understanding the major trends that trigger new events, as well as responding to these daily occurrences, is essential for formulating medium- to long-term business plans. In this study session, Owls Consulting Group, which provides support for responding to geopolitical risks and economic security, will explain the megatrends behind the current situation and clarify how companies should address the expansion of geopolitical divisions.

● "Virtual Experiments by AI: Exploration of New Targets for Chemoresistance" As a means to evaluate the functions of drug discovery target candidate molecules, there are experimental evaluation methods such as gene knockout. However, evaluating in disease models and experimentally assessing many genes poses challenges that are not easily addressed. To solve this issue, we developed a unique analytical method called "Virtual Experiments," which virtually knocks out target genes from a disease network created by our proprietary natural language processing AI engine, allowing us to reconstruct the disease network and predict the disease state after gene knockout. In this seminar, we will introduce solutions utilizing Virtual Experiments, using the challenge of chemoresistance as an example. *For more details about this seminar, please refer to the registration page.

In the Rare Disease Analysis Series, we will introduce the system overview and utilization methods of the paper exploration AI system "KIBIT Amanogawa," which can instantly detect highly similar and relevant paper information, genes, and diseases based on input words or sentences from a vast amount of paper information, with a focus on target exploration for rare diseases. The theme of this session is "Stevens-Johnson Syndrome." Stevens-Johnson Syndrome is a rare disease characterized by symptoms resembling rashes or burns accompanied by high fever affecting the skin and mucous membranes throughout the body. The main cause is believed to be related to pharmaceuticals, although some cases are known to occur in association with viral infections. In many cases, recovery occurs through treatment, but severe cases can lead to death due to sepsis or multiple organ failure. In this seminar, we will demonstrate how to extract genes related to Stevens-Johnson Syndrome using paper exploration AI and establish hypotheses for treatment targets, providing effective ways to utilize KIBIT Amanogawa to gain insights for research.

"Exploration of New Indications for Drugs Targeting FAAH through AI-Driven Two-Dimensional Mapping" Researchers continuously catch up with the latest information that is updated daily, imagining and verifying the relationships between genes and between genes and diseases. However, it is not easy to connect all the information and envision those relationships from a comprehensive and overarching perspective. Our proprietary natural language processing AI engine, "KIBIT," learns the currently available information and presents the relationships, including potential future possibilities, in a comprehensive and overarching manner. In this seminar, we will introduce a method for comprehensively exploring optimal target diseases for the genes of interest using two-dimensional mapping that visualizes the similarities between the genes of interest and diseases/symptoms, created with "KIBIT," along with specific examples. For more details, please refer to the application page.

As digitalization rapidly advances, there is a noticeable issue of various forms of data being scattered throughout the company. As companies progress in their digital transformation, the amount of data they hold also increases, leading to a large accumulation of data across various systems within the organization. However, the dispersion of data across multiple systems and services in daily operations often complicates business processes and can significantly reduce operational efficiency. Therefore, we will introduce a system that organizes unstructured data scattered within the company using a technology distinct from FRONTEO's generative AI, enabling quick access when needed, along with actual case examples.

Japan has a mature market for life insurance and pension insurance, and its scale is one of the largest in the world. To maintain this mature market and ensure that insurance companies retain their competitiveness, it is a global trend for insurance companies to respond to the capital requirements of their businesses and to expand the use of reinsurance as a strategy until new insurance is issued. In light of these global trends and their impact on Japan, this webinar will explain the following: - Factors that are rapidly increasing the demand for reinsurance in Japan's life insurance and pension insurance market - The optimal structure of reinsurance transactions for Japanese life insurance companies - Regulatory and counterparty risks associated with these reinsurance transaction structures - Outlook for reinsurance transactions in the coming year and beyond

In today's business environment, where crossing borders has become inevitable for companies, international arbitration and mediation are gaining attention and being utilized as dispute resolution methods that can ensure enforcement while maintaining confidentiality. However, Japanese companies are often unfamiliar with the evidence disclosure processes that take place and how to preserve evidence at a day-to-day level, leading them to inadvertently leave behind careless evidence. Therefore, in this presentation, I will specifically explain how to create arbitration and mediation clauses that are trending, how to secure evidence in daily operations, and methods of defense in case of emergencies.

In this seminar, we will introduce the system overview and utilization methods of the paper exploration AI system "KIBIT Amanogawa," which can instantly detect papers, genes, and diseases that are highly similar or relevant to the words or sentences inputted from a vast amount of paper information, presented by an AI consultant familiar with the system. This time, we will utilize the paper exploration AI with the theme of countermeasures against "frailty." Frailty refers to a state in which muscle strength and activity decline with aging, leading to difficulties in daily life, and it falls between a healthy state and a state requiring nursing care. It is characterized by a high risk of progressing to a state requiring nursing care, but it is also a condition where functional abilities can sometimes return to normal. Therefore, early detection and appropriate treatment or prevention are considered important. In this seminar, we will explore diseases, related substances, and pharmaceuticals that may be associated with frailty using AI, and through demonstrations that seek hints for countermeasures and prevention, we will convey effective ways to utilize KIBIT Amanogawa.

【Event Overview】 ◆ Date and Time: November 12, 2024 (Tuesday) 15:00 - 16:00 ◆ Format: Free online seminar (A viewing URL will be sent after registration) ◆ Tool Used: Zoom Webinars (You can participate via your browser without downloading Zoom) ◆ Capacity: 1,000 participants ◆ Participation Conditions: - We kindly ask those using free email addresses, those from competing companies, law firms, or those whose affiliations are unclear to refrain from applying. - When accessing ZOOM on the day of the event, please enter the name and email address you registered with in the ZOOM participation input field. ◆ How to Apply ◆ Please apply through our company website. https://lp.fronteo.com/BP-WBN-L-20241112_registration.html?utm_source=ipros&utm_medium=affiliate&utm_campaign=20241112LTAI *For more details, please refer to the related links or feel free to contact us.

"The next big thing after AI is anti-aging" - In recent years, as generative AI has seen explosive growth, "anti-aging" is emerging as the next global trend. In the healthcare sector, a multifaceted approach that includes drug administration, food, traditional medicine, and exercise will become increasingly important. In this seminar, the developer of the paper exploration AI "KIBIT Amanogawa," which can discover the unknown from the known, will introduce new possibilities for anti-aging revealed through AI analysis. In particular, we will focus on "Klotho," a substance closely related to aging prevention, and "s-Klotho," which leaks into the bloodstream and circulates throughout the body. We will explain how foods like "mugwort" and exercise can activate this substance and contribute to the prevention and treatment of age-related heart disease, diabetes, Alzheimer's disease, and more, through case studies of analysis using papers and AI.

**Title:** Know-How for Harassment and Internal Reporting Investigations: Case Study on Sexual Harassment - Explaining the Investigation Process and Hearing Techniques through Specific Examples **Overview:** The Whistleblower Protection Act and the Power Harassment Prevention Act require the establishment of a system for investigating and responding to whistleblower and harassment reports. However, there are very few opportunities to receive practical training on how to conduct internal reporting investigations, including the flow of the investigation, the order and types of questions to ask during hearings, what other materials should be collected besides hearings, and how to determine the existence of facts as a result of the investigation. In this seminar, a lecturer who is a lawyer with extensive experience in handling harassment and internal reporting investigation cases will share practical know-how on conducting harassment and internal investigations, including the flow of the investigation, the order of hearings, questioning methods, and fact-finding techniques, all based on specific examples that can be immediately applied.

**Title:** Know-how for Harassment and Internal Reporting Investigations: Case Study on Power Harassment - Explaining the Investigation Process and Hearing Techniques through Specific Examples **Overview:** The Whistleblower Protection Act and the Power Harassment Prevention Act require the establishment of a system for investigating and responding to public whistleblowing and harassment reports. However, there are very few opportunities to receive practical training on how to conduct internal reporting investigations, including the flow of the investigation, the order and types of questions to ask during hearings, what other materials should be collected aside from hearings, and how to determine the existence of facts as part of the investigation results. In this seminar, a lecturer who is a lawyer with extensive experience in handling harassment and internal reporting investigation cases will share immediately applicable know-how on the flow of harassment and internal investigations, the order of hearings, questioning methods, and methods for fact-finding, based on specific examples.

**Title:** Know-How for Harassment and Internal Reporting Investigations: 1_Basic Knowledge Edition - Explaining the Flow of Investigations and Hearing Techniques through Specific Cases **Overview:** The Whistleblower Protection Act and the Power Harassment Prevention Act require the establishment of systems for investigating and responding to public and harassment reports. However, there are very few opportunities to receive practical training on how to conduct internal reporting investigations, including the flow of the investigation, the order and types of questions to ask during hearings, what other materials should be collected aside from hearings, and how to determine the existence of facts as a result of the investigation. In this seminar, a lecturer who is a lawyer with extensive experience in handling harassment and internal reporting investigation cases will share practical know-how on the flow of harassment and internal investigations, the order of hearings, questioning methods, and fact-finding techniques based on specific cases that can be immediately applied.

Recently, various companies across different industries have been victims of cyberattacks, including ransomware, resulting in long recovery times and significant financial losses. Additionally, the leakage of information held and managed by companies can damage their reputation and lead to a substantial decline in business performance, depending on how the situation is handled. Even though companies are victims of cyberattacks and information leaks, if they fail to respond appropriately during normal times or crises, there is a risk that the company and its executives may face lawsuits for damages or criminal liability. Given the significant risks posed by cyberattacks and information leaks, it is essential for multiple stakeholders, including company executives, general affairs, human resources, legal, and IT security departments, to implement response measures across the organization during both normal and crisis situations. Attorney Masayuki Otake, who has extensive experience investigating numerous cases as a prosecutor in charge of cybercrime and intellectual offenses, will explain the important legal and practical points to consider in such situations.

The Important Economic Security Information Protection Utilization Law, established in May 2024, is a new framework aimed at utilizing economic security policies by providing confidential information held by the government to the private sector while ensuring its protection. However, many companies express doubts such as, "Is this relevant to us in the first place?" "How can we utilize the information provided by the government?" and "Is there enough benefit to justify the costs?" Although operational standards and government ordinances are becoming clearer, it remains difficult for companies to see a concrete path on how to engage with this law. In this lecture, a speaker who has recently worked at the Ministry of Economy, Trade and Industry as a policy official for security clearance and is now supporting companies in their economic security responses as a lawyer will present. Taking into account both public and private perspectives, the lecture will clarify the potential for companies to utilize the security clearance system and will provide a detailed explanation of practical issues and challenges. It is hoped that this lecture will help view the security clearance system not merely as a government information management measure, but as a risk management measure to enhance corporate capabilities, and will assist in the necessary preparations and considerations for that purpose.

Our country's economy is finally showing signs of recovery from prolonged deflation. However, the declining birthrate, aging population, and population decrease continue unabated, and the relative position of our economic and scientific and technological power, which are the foundation of national strength, is on a downward trend. Additionally, as the security environment surrounding our country becomes increasingly severe, and with the uncertainty stemming from changes in the U.S. administration and political instability in South Korea, the necessity to maintain and acquire our country's autonomy, superiority, and indispensability is undeniably rising. Looking ahead at the international situation, we will discuss what economic security policies we will implement in the future.

"Analysis of Side Effects of Epigenetic Drugs Using Natural Language Processing AI - Focusing on Cardiotoxicity of HDAC Inhibitors -" Conventional pharmaceuticals primarily target proteins such as receptors, but in recent years, epigenetic drugs that target molecules related to controlling protein expression "upstream" have been developed. Among these, the already approved epigenetic drug histone deacetylase (HDAC) inhibitors have achieved significant results in the oncology field with a mechanism of action that is unprecedented. However, it has been reported that these drugs can induce cardiotoxicity, and many details of the mechanisms remain unclear. In this webinar, we will report on the application of FRONTEO's uniquely developed natural language processing AI "KIBIT" to analyze the cardiotoxicity mechanisms of approved HDAC inhibitors, which yielded interesting results. *For more details, please refer to the registration page.*

The Chinese economy is slowing down far more than official statistics suggest. The persistently high unemployment rate is exacerbating public safety issues. In 2025, the Xi Jinping administration is set to announce various economic policies aimed at stimulating the economy, which are expected to be implemented. However, there are numerous challenges, including the excesses of the real estate downturn. In the near term, there is no prospect for economic recovery. Amidst this, a Trump administration 2.0 is expected to be established, with policies towards China being strengthened. The intensification of US-China tensions is inevitable, and Japan needs to develop its own strategy to avoid being caught up in it. This lecture will explore the nature of Japan's unique strategy.

**Title:** "Preventive Measures and Response to Trade Secret Misappropriation by Departing Employees" Part 1: Response to Emergencies - Initial Response and Criminal Measures **Overview:** As employment mobility increases, cases are rising where key employees take trade secrets with them upon leaving and use them at rival companies, resulting in significant damages. Preventing the misappropriation of trade secrets is of utmost importance, but it is impossible to prevent all instances of misappropriation by departing employees. It is also necessary to understand what initial actions must be taken when the misappropriation of trade secrets is discovered, as well as what legal measures can be pursued. Since 2023, we have held a total of five real seminars and webinars featuring attorney Kyosuke Kaneko, who has experience representing victimized companies in cases where departing employees were sentenced to prison for the overseas misappropriation of trade secrets. Due to high interest, attendance at the webinars has ranged from 400 to 600 participants, and many have expressed a desire for more detailed explanations in surveys. In response to these requests, we will conduct a series of three consecutive lectures. If you wish to deepen your understanding of trade secrets, please join us.

The leniency system (reduction of penalties) established by the Japan Fair Trade Commission has gradually accumulated usage records since the introduction of the investigation cooperation reduction system in the 2019 amendment, and the utilization rate of the leniency system in cases subject to administrative sanctions for cartels and other violations is also at a high level. Therefore, attorney Naoki Uemura, who has experience as a former Fair Trade Commission examiner, will explain the current usage status of the leniency system and the practical points that are important when utilizing the leniency system. Additionally, regarding the digital forensic investigation required from the initial stage of utilizing the leniency system, effective and efficient investigation methods will be explained in collaboration with a representative from FRONTEO.

As frequently reported in Japan, export controls and other economic security regulations between the U.S. and China have been strengthened year by year. Until about ten years ago, there was little need for Japanese companies, except for a few, to pay attention to economic security regulations in their China operations. However, in recent years, U.S. regulations have been frequently tightened, and in response, China's regulations have also been strengthened. Therefore, it has become essential to understand and keep updated on both China's and the U.S.'s economic security regulations when making investment and management decisions in China. This seminar will primarily explain the economic security regulations under Chinese law that Japanese companies should pay attention to when expanding their operations in China, as well as provide an overview of the U.S. export controls that are mainly problematic in China operations. [Program] (Subject to some changes) (1) China's perspective on security (2) Export controls on goods and technology (3) Investment regulations for foreign capital in key industries (4) Regulations on data technology transfer (5) Ensuring technological superiority (6) Countering sanctions against China (7) Anti-espionage law (8) U.S. export controls that are mainly problematic in China operations

As employment mobility progresses, there has been an increase in cases where key personnel take trade secrets with them upon resignation and use them at rival companies, resulting in significant damages. Preventing the unauthorized removal of trade secrets is of utmost importance, but it is impossible to prevent all instances of removal by departing employees. It is also necessary to understand what initial actions must be taken when the removal of trade secrets is discovered, as well as what legal measures can be pursued. Since 2023, we have held a total of five real seminars and webinars featuring attorney Kyosuke Kaneko, who has experience representing victimized companies in cases where departing employees were sentenced to prison for the overseas removal of trade secrets. There has been a high level of interest, with participation ranging from 400 to 600 individuals, and many have expressed a desire for more detailed explanations in surveys. In response to these requests, we will conduct a series of three consecutive lectures. If you wish to deepen your understanding of trade secrets, please join us. 【Topic of the 2nd Session】 - What are trade secrets? - Can we request the use or disclosure of trade secrets taken by departing employees?

In recent years, Third-Party Funding (TPF) has rapidly gained recognition as a practical option for companies considering litigation or international arbitration. TPF allows parties to pursue legal claims without using their own funds, providing a new option to transform legal risks into strategic assets. In this seminar, we will welcome Ms. Arl Rivera-Drella, who has extensive experience as an arbitrator, representative, and attorney, having been involved in over 200 international arbitration cases. The seminar will cover the basics of TPF, trends in major countries, important considerations for Japanese companies, and practical insights based on actual cases. The first half will be conducted in Japanese, while the second half will proceed with slow English and Japanese slides to ensure everyone understands the content.

As the fluidity of employment increases, there has been a rise in cases where key personnel take trade secrets when they leave and use them at rival companies, resulting in significant damages. We have invited attorney Kyosuke Kaneko, who has experience representing victimized companies in cases where former employees were sentenced to prison for taking trade secrets abroad, to conduct a total of five real seminars and webinars on crisis response since 2023. There has been a high level of interest, with hundreds of participants each time, but many have also expressed a desire for explanations on preventive measures. In response to these requests, we are conducting a series of three consecutive lectures. The first and second sessions focused on crisis response. Those interested can access the archived recordings. The third session will explain preventive measures. We encourage your participation. 【Topic of the 3rd Session】 - What are trade secrets? - What is confidentiality management? - Court cases where confidentiality management was recognized and where it was not - Development of employment regulations and non-disclosure agreements - Effectiveness and content of internal training - Asset management tools, MDM, and digital forensics

In 2024, the number of M&A transactions reached a record high. At the same time, "unexpected troubles" are certainly on the rise. In this seminar, attorneys Shunsuke Inoue and Risa Haruyama from Hibiya Nakata Law Office will clearly explain from a legal perspective, based on actual cases and court rulings in which they were involved as advisors, "In what situations did problems arise, and why?" and "How could they have been prevented?" 【Content】 • Introduction: Increasing M&A, Increasing Troubles • Troubles Related to Acquisition Amounts: "Deciding Later" Doesn't Get Decided • Troubles Related to Representations and Warranties: "Absolutely Not" is Absolutely Not • Troubles Related to Covenants: "Going Solo" is Difficult • Conclusion: What Legal Professionals Can Do to Prevent Future Troubles • Q&A