Virus purification chromatography "Cellufine Sulfate"
Cellufine Sulfate allows for the easy operation of purifying and concentrating virus particles with good reproducibility.
Cellufine Sulfate is an affinity chromatography resin used for virus purification. It has a proven track record of use in vaccine manufacturing by global pharmaceutical companies worldwide. The density gradient ultracentrifugation method used for virus purification has several drawbacks, including lead time, reproducibility, and safety issues. Cellufine Sulfate can address these shortcomings due to its chromatography capabilities. 【Features】 ■ Affinity activity for live viruses, inactivated viruses, and split viruses ■ Affinity for virus-derived antigens, bacteria-derived antigens, and heparin-binding proteins ■ The chromatography process is closed, ensuring high safety and low risk of microbial contamination ■ Effective in removing endotoxins that may have contaminated the manufacturing process, as it does not adsorb endotoxins ■ Due to its negatively charged ligands, it does not adsorb positively charged impurities such as host-derived DNA ■ Physically robust and highly durable as it is based on cellulose ■ Sterilization through multiple autoclave cycles is possible *For more details, please refer to the PDF materials or feel free to contact us.
basic information
【Other Features】 ■ More efficiently removes culture media and host cell-derived impurities from the target substance compared to density gradient ultracentrifugation. ■ Achieves both purification and concentration simultaneously compared to density gradient centrifugation, as it is purified by chromatography. ■ Improves yield due to the ability to adsorb and elute under mild conditions near neutrality. ■ Capable of operation at high flow rates due to pressure resistance. ■ Extensive track record of use in large-scale manufacturing columns. ■ Numerous reference cases including papers and patents. 【Adsorption Characteristics for Viruses, Viral Antigens, and Microbial Antigens】 - Rabies virus - Influenza virus - Japanese encephalitis virus - West Nile virus - Dengue virus - Feline leukemia virus - Feline calicivirus - RSV (Respiratory Syncytial Virus) - Human herpesvirus - Human measles virus - Human parainfluenza virus - Human coronavirus (OC43) - Herpes simplex virus gA and gB glycoprotein subunits - Hepatitis B surface antigen - Hemagglutinin derived from Bordetella pertussis - Influenza virus hemagglutinin *For more details, please refer to the PDF document or feel free to contact us.
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Model number/Brand name
Cellufine Sulfate
Applications/Examples of results
It can be used for the purification of viruses and vaccines. Cellufine is a chromatography resin made in Japan that has a proven track record at Global Pharma. *For more details, please refer to the PDF document or feel free to contact us.
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