Efficient purification method for monoclonal antibodies using Cellufine.
The amounts of leaked protein A and host-derived DNA have been reduced to below the detection limit!
In the downstream (purification process) of monoclonal antibody (mAb) manufacturing, it is common to use chromatography resin for the Protein A column capture step and the polishing step, which is called impurity removal. This document introduces a method that connects two columns used in the polishing step and employs them in flow-through mode. By using this method, we were able to efficiently remove impurities without the cumbersome operations of adjusting pH and electrical conductivity between the polishing process columns. [Contents] ■ Introduction ■ Experimental Methods ■ Analysis ■ Results ■ Conclusion ■ Acknowledgments *For more details, please refer to the PDF document or feel free to contact us.
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