Nucleic acid synthesis-related products
We offer a variety of reagents for nucleic acid synthesis, dehydrating solvents, reagents for purification and analysis, columns, and related equipment!
At Kanto Chemical, we offer a range of reaction auxiliary reagents and related equipment used for nucleic acid synthesis. 【New Products】 -NEW- ◆ Capping Reagents ◆ Oxidation Reagents ◆ Sulfuration Reagents ◆ 2mol/L TEAA Solution, pH 7.0 【Product Lineup】 ■ Dehydrating Solvents for Organic Synthesis ■ Synthetic Reagents: Deprotection (Detritylation), Coupling, Capping, Stabilization (Oxidation/Sulfuration), Post-processing ■ ESSCEE Biotech Products: Reaction Auxiliary Reagents (Deprotection Agents, Activators, Capping Agents A & B, Oxidants), Adapters ■ Reagents for Purification and Analysis: Ion Pair-Reversed Phase Chromatography, Anion Exchange Chromatography, Electrophoresis ■ Chemical Evaluation Research Institute (CERI): L-column 3 ■ Agilent Technologies: Ion Pair Reversed Phase Columns, Anion Exchange Columns ■ Global Life Science Technologies Japan: Ion Exchange Membrane Products, Ultrafiltration Products ■ Natias: Blockmer (Nucleic Acid Raw Materials), CpG ODN, Contract Synthesis ■ Custom Solutions Available For more details, please download the catalog or feel free to contact us.
basic information
■Structure of Nucleic Acids Nucleic acids refer to deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). They have a repetitive structure of nucleotides. The building blocks, nucleotides, consist of a nucleic acid base, a five-carbon sugar (ribose), and phosphate. ■Nucleic Acid Medicines Nucleic acid medicines are gaining attention as a new drug discovery modality. They are drugs based on natural or chemically modified nucleotides, which act directly on the body without mediating gene expression and are characterized by being produced through chemical synthesis. ■Synthesis of Nucleic Acids (Oligonucleotides) Current nucleic acid (oligonucleotide) synthesis primarily uses the solid-phase synthesis method (phosphoramidite method) developed in the 1980s. Nucleotides are added on solid-phase supports such as polymer beads, repeating the synthesis cycle until the desired chain length is achieved, with the following steps 1 to 4 constituting one cycle. 【Synthesis Cycle】 1. Deprotection: Removal of protective groups from the reaction site 2. Coupling: Reaction of nucleic acid monomers 3. Capping: Protection of unreacted materials 4. Stabilization: Oxidation or sulfuration after coupling ↓ 5. Post-processing 6. Purification
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For more details, please refer to the catalog below or feel free to contact us.
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Since its establishment in 1944, Kanto Chemical has continued to develop competitive products in four fields: reagents, electronic materials, clinical diagnostic reagents, and chemical products, under a strict quality control system as a comprehensive reagent manufacturer.