We will launch the following new products in April 2025. ● General-purpose reagents (3 items) We are reviewing the packaging capacities and consolidating general-purpose reagents of special grade, deer special grade, and deer first grade standards. Accordingly, we are sequentially informing you of products that will be discontinued as stock runs out, and we will sell new capacities of standard products that are not subject to consolidation as alternatives to the discontinued items. ● High-purity solvent Primepure series (1 item) In the Primepure series, we will newly sell 3L packaging of acetonitrile. The "Primepure" series guarantees the highest purity specifications among commercially available reagents, exceeding existing specifications that are guaranteed by JIS special grade standards and by application. ● Ionic liquids (1 item) We will newly sell DEMEBF4 as our product from the ionic liquids that were sold under a joint label with Nisshinbo Holdings Inc. Ionic liquids are utilized in a wide range of fields such as separation, extraction, reaction solvents, electrochemical devices, tribology, vacuum technology, and bio-related applications, and are expected to be the next-generation solvent.

We will launch the following new products in March 2025. ● Reagents for LC/MS (2 items) In LC/MS analysis, volatile salts such as ammonium acetate and ammonium formate are commonly used as buffer solutions for pH adjustment of the mobile phase. These buffer solutions are also included in analytical methods for pesticide residue analysis in food and official methods such as the Waterworks Law. The newly sold "1 mol/L ammonium acetate solution" and "1 mol/L ammonium formate solution" guarantee "LC/MS testing compatibility," "metal guarantee," and "PFAS testing compatibility," in addition to the existing product guarantees, and implement stricter quality control than products for high-performance liquid chromatography. ● General-purpose reagents We will newly sell the "Sikajenius Vancomycin Resistance Gene Real-Time PCR Detection Kit." This kit uses a 4-plex real-time PCR to simultaneously detect the vanA, vanB, and vanC vancomycin resistance genes, as well as an internal control (IC) to check for PCR inhibition. For more details, please refer to the related links or feel free to contact us.

We will launch the following new products in February 2025. ● Simple Analysis Kit We will newly sell the "Dissolved Oxygen Kit 30" manufactured by Kyoritsu Rika Co., Ltd. The measurement principle of this product is based on the alkaline indigo carmine method, allowing measurements similar to those of conventional products. ● General-purpose Reagents (4 items) We are reviewing the packaging capacities and consolidating products for general-purpose reagents of special grade, deer special grade, and deer grade 1 standards. Accordingly, we are sequentially informing you of products that will be discontinued as supplies run out, but we will sell new capacities of standard products that are not subject to consolidation as alternatives to the discontinued items. ● Quality Control for Gene-related Testing (24 items) Since the outbreak of COVID-19, the importance and necessity of gene-related testing have increased. We will sell quality control products for gene-related testing devices compatible with Microbiologics, including BD MAX, Biofire, Filmarray, Roche Cobas, and Verigene. Please check the list of new products from the related link.

We will launch the following new products in January 2025. ● Reagents for Pharmaceutical Testing We will newly sell "Dilute Hydrochloric Acid" prepared in accordance with "Hydrochloric Acid, Dilute" as described in the Japanese Pharmacopoeia. It is used for testing various pharmaceuticals and herbal medicines in the Japanese Pharmacopoeia. ● Reagents for Nucleic Acid Synthesis We will newly sell "Dichloroacetic Acid" used in the deprotection reaction of the phosphoramidite method. This product guarantees the value of "Trichloroacetaldehyde Monohydrate." ● General-purpose Reagents (5 items) We are reviewing the packaging capacities and consolidating products for special grade, deer special grade, and deer first grade general-purpose reagents. We will sell new capacities of standard products that are not targeted for consolidation as substitutes for discontinued items. ● Acetonitrile/Water/Trifluoroacetic Acid (50:47.5:2.5) We will newly sell a mixed solvent suitable for dissolving matrix reagents and calibration standards used in bacterial analysis by MALDI-TOF MS. ● Nucleic Acid Synthesis 2 mol/L TEAA Solution, pH 7.0 TEAA is widely used as an ion-pair reagent. We have newly prepared a 200 mL packaging. Please check the list of new products from the related link.

Mycoplasma spp. is a type of true bacteria known to cause various diseases such as pneumonia, otitis media, arthritis, and mastitis in production animals like cattle. In this third seminar, titled "Clinical Aspects of Bovine Mycoplasma Infections," we will hear presentations on insights and responses from clinical practice. Date and Time: January 31, 2025 (Friday) 15:30 – 18:00 (scheduled end) [Chair] Professor Hidetaka Iwano, School of Veterinary Medicine, Rakuno Gakuen University Professor Goki Higuchi, School of Veterinary Medicine, Rakuno Gakuen University [Speakers] Dr. Koji Nishi, Monbetsu Livestock Clinic, Okhotsk General Center, Hokkaido Agricultural Mutual Aid Association Dr. Tetsu Obayashi, Shikaoi Livestock Clinic, Tokachi General Center, Hokkaido Agricultural Mutual Aid Association Dr. Kazuhiro Kawai, Laboratory of Veterinary Hygiene, School of Veterinary Medicine, Azabu University Registration: Please register using the participation application form at the URL below. Application Period: December 9, 2024 (Monday) – January 30, 2025 (Thursday)

We will launch the following new products in December 2024. ● Simple Analysis Kit (2 items) We will newly sell a modified version of the "Pack Test Phosphate" manufactured by Kyoritsu Rika Co., Ltd. The current product requires a two-step operation, but the new product will only require a one-step operation of sucking the water sample into a tube. There will be no changes to the measurement principle, measurement range, or standard color types. ● General-purpose Reagents (3 items) We are reviewing the packaging capacity and consolidating product specifications for general-purpose reagents of special grade, deer special grade, and deer grade 1. We will sell new capacities for specifications that are not targeted for consolidation as replacements for discontinued items. ● Cell Dispersion Enzyme (5 items) "Brighterase" is a recombinant enzyme produced using the Brevibacillus expression system, achieving low endotoxin and animal-derived component-free quality. It can be used to isolate cells from biological materials. ● Quality Control for Genetic Testing (5 items) Microbiologics sells quality control products for the GeneXpert genetic testing device sold by Beckman Coulter. Please check the list of new products from the related link.

We will launch the following new products in November 2024. ● Environmental Analysis Standard Products (6 items) We have newly introduced environmental analysis standard products from Analytical Standard Solutions and LGC Standards. The newly added items are standard products for compounds with newly added or changed residue standards. ● General Reagents (6 items) We are reviewing the packaging capacities and consolidating product specifications for general reagents of special grade, deer special grade, and deer grade 1. As a result, we have launched new capacities for specifications that are not subject to consolidation as alternatives to discontinued items. ● Growth Factor Substitute Peptides (2 items) The growth factor substitute peptide "FGF2 substitute peptide" demonstrates physiological activity equal to or greater than that of the existing recombinant protein "FGF2" and shows high stability in culture media, making it expected to be used in the culture of mesenchymal stem cells and iPS cells. ● Cell Culture Media (2 items) This product is an animal-free medium that does not contain human or animal-derived components, suitable for regenerative medicine research, and allows for the proliferation of human mesenchymal stem cells while maintaining their undifferentiated state. Please check the list of new products from the related link.

We will launch the following new products in September 2024. ● AIQS-related reagents (1 item) This product is a reagent for pH adjustment as described in the "Provisional Manual for Screening Analysis Method using AIQS-GC." AIQS (Automated Identification and Quantification Systems) is a screening analysis system developed by a research group led by Professor Kadokami and Associate Professor Miyawaki at Kitakyushu City University. ● Reagents for natural product chemistry research (5 items) We have newly added 5 items centered around the red yeast rice pigment components such as ankaflavin and monascin, which are included in functional foods. Please check the list of new products from the related link.

Mycoplasma spp. is a type of true bacteria known to cause various diseases such as pneumonia, otitis media, arthritis, and mastitis in production animals like cattle. This seminar will focus on bovine respiratory disease, and esteemed speakers will provide necessary information for management, including insights on bovine mycoplasma. Date and Time: January 20, 2023 (Friday) 15:30 - 17:40 (scheduled to end) Chairpersons: Professor Hidetaka Iwano, Faculty of Veterinary Medicine, Rakuno Gakuen University Professor Goki Higuchi, Faculty of Veterinary Medicine, Rakuno Gakuen University Speakers: Dr. Satoshi Gonpei, Faculty of Veterinary Medicine, Rakuno Gakuen University Professor Toshihide Kato, Special Appointment Professor, Rakuno Gakuen University (Microbial Chemistry Research Institute Co., Ltd.) Dr. Tetsuya Goto, Livestock Department, JA Saroma Registration: Please register using the participation application form at the URL below. Application Period: November 11, 2022 (Friday) - January 19, 2023 (Thursday)

We will launch the following new products in February 2022. For details about the products, please contact our branch or sales office. <Analysis Reagent Related Products> ● Drug Simple Detection Kit DRIVEN-FLOW M7-AC We will newly sell the DRIVEN-FLOW M7-AC as part of the DRIVEN-FLOW series of drug simple detection kits. ● Drug Simple Detection Kit: Zolpidem/Zopiclone/Zaleplon Rapid Test We will newly sell a drug simple detection kit that can detect the sleep medications Zolpidem, Zopiclone, and Zaleplon. ● Nitrosamine Standard Products We will newly sell nitrosamine standard products from Dr. Ehrenstorfer and TLC Pharmaceutical Standards.

Mycoplasma spp. is a type of true bacteria, with approximately 120 species reported. In production animals such as cattle, early detection and countermeasures for certain Mycoplasma species are becoming increasingly important. This seminar will focus on bovine mycoplasma, with knowledgeable speakers providing essential information for management. We sincerely look forward to your participation. Date and Time: February 25, 2022 (Friday) 18:00 - 19:30 (scheduled to end) Chair: Professor Hidetaka Iwano, Faculty of Veterinary Medicine, Rakuno Gakuen University Speakers: Professor Goki Higuchi, Faculty of Veterinary Medicine, Rakuno Gakuen University Mr. Masaru Matsumoto, former JA Mashu Lake Dr. Naomi Iwano, COO/Head of Genetic Analysis Division, Japan Animal Special Diagnostics Co., Ltd. Ms. Misaki Kobayashi, Biochemical Division, Kanto Chemical Co., Ltd. Registration: Please register using the participation application form at the URL below. Application Period: December 27, 2021 (Monday) - February 18, 2022 (Friday)

"The Chemical Times" is a periodic publication launched by Kanto Chemical in 1950. It is published four times a year and features research papers on a wide range of fields including chemistry, pharmaceuticals, physics, biology, and more. We have now published issue 263 of "The Chemical Times," which can be accessed via "View Release Source." Additionally, back issues are also available, so please take a look. [Contents] Special Feature: Flow Chemistry ◆ Welcoming the New Year ◆ Reaction Integration Based on Flow Microchemistry ◆ Separation and Purification Technologies for Continuous Flow Processes ◆ Based on Polystyrene-Crosslinked Phosphines ◆ The Fusion of Flow Chemistry and Machine Learning

Mycoplasma spp. is a type of true bacteria, with approximately 120 species reported. In production animals such as cattle, it is important to detect and take measures against certain Mycoplasma species early. This seminar will focus on bovine mycoplasma, and esteemed speakers will provide necessary information for management. We sincerely look forward to your participation. Date and Time: February 25, 2022 (Friday) 18:00 - 19:30 Chair: Dr. Hidetaka Iwano, Faculty of Veterinary Medicine, Rakuno Gakuen University Speakers: Dr. Goki Higuchi, Faculty of Veterinary Medicine, Rakuno Gakuen University Former JA Mashuko, Dr. Yutaka Matsumoto Naomi Iwano, Japan Animal Special Diagnostics Co., Ltd. Misaki Kobayashi, Kanto Chemical Co., Ltd., Biochemical Department Registration: Please register using the participation application form at the URL below https://v2.nex-pro.com/campaign/36975/apply (This will take you to the seminar distribution company's page) Application Period: December 27, 2021 (Monday) - February 18, 2022 (Friday)

We will launch the following new products in December 2021. For details about the products, please contact our branch or sales office. Products related to analytical reagents Daicel Corporation CHIRALPAK IK Series We will newly sell the solvent-resistant chiral columns of the CHIRALPAK IK Series.