Iridium catalyst for chiral amine synthesis

Excellent functional group tolerance, capable of reacting with a wide range of substrates! Chiral amines can be obtained directly from ketones! Furthermore, the reaction can also be performed in a one-pot manner!

At Kanto Chemical, we have developed and sold practical reductive amination iridium catalysts that can synthesize amines under mild conditions, and we have now developed a new asymmetric reductive amination catalyst. In particular, in the reductive amination reaction combined with amino alcohols as asymmetric auxiliaries, it has become possible to easily synthesize optically active amines, which have been difficult to synthesize asymmetrically until now. We are pleased to announce the addition of the PSA18 series, which has high reactivity with linear ketone substrates, to our product lineup. We encourage you to utilize it in product development and research. 【Features】 ■ High performance High catalytic activity, high stereoselectivity, high functional group selectivity ■ Short reaction process No need for isolation of imines; reactions can be performed in one pot up to deprotection ■ Easy operability No need for hydrogen gas or pressure-resistant containers for both reductive amination and deprotection processes For more details, please download the catalog or feel free to contact us.

basic information

Optically active amines are useful compounds widely used in various fields, such as the synthesis of physiologically active substances like pharmaceuticals, pesticides, and functional materials. Their synthesis methods include optical resolution of racemates and asymmetric reduction of imines. At Kanto Chemical, we offer highly active asymmetric catalysts for reductive amination that allow for the synthesis of chiral amines from ketone compounds under mild conditions, by combining amino alcohols as asymmetric auxiliaries.