Improved asymmetric reduction catalyst & triflate catalyst
It can be used for hydrogen transfer asymmetric reduction reactions and asymmetric hydrogenation reactions of ketones.
■Improved Asymmetric Reduction Catalyst Asymmetric ruthenium complexes with optically active tosyl diamines as ligands are very useful as asymmetric reduction catalysts for ketones; however, sufficient enantioselectivity may not be achieved for bulky substrates. At Kanto Chemical, we offer an improved asymmetric reduction catalyst with modified sulfonyl groups that exhibits high enantioselectivity for bulky substrates. ■Triflate Catalyst By introducing dissociative anionic ligands into hydrogen transfer-type asymmetric ruthenium catalysts with arene ligands and tosyl diamine ligands, hydrogen is activated, allowing for more efficient asymmetric hydrogenation reactions of ketones compared to hydrogen transfer-type asymmetric reduction catalysts. The triflate catalyst does not contain strong bases, so the reaction proceeds under neutral to weakly acidic conditions. Therefore, it is useful for the asymmetric hydrogenation of unstable cyclic ketones, phenacyl chloride, α-hydroxyacetophenone, and other compounds under basic conditions. For more details, please download the catalog or feel free to contact us.
basic information
By introducing dissociative anionic ligands into hydrogen transfer asymmetric ruthenium catalysts that have arene ligands and tosyl diamine ligands, hydrogen is activated, allowing for more efficient asymmetric hydrogenation reactions of ketones compared to hydrogen transfer asymmetric reduction catalysts. Since triflate catalysts do not contain strong bases, the reactions proceed under neutral to weakly acidic conditions. Therefore, they are useful for the asymmetric hydrogenation of unstable cyclic ketones, phenacyl chloride, α-hydroxyacetophenone, and other compounds under basic conditions.
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For more details, please refer to the catalog below or feel free to contact us.
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Since its establishment in 1944, Kanto Chemical has continued to develop competitive products in four fields: reagents, electronic materials, clinical diagnostic reagents, and chemical products, under a strict quality control system as a comprehensive reagent manufacturer.