Patcore Inc. (Headquarters: Tokyo) has partnered with Chemical.AI (USA/China), a global leader in AI technology for chemical synthesis route design, to begin domestic provision of the AI retro-synthesis platform "ChemAIRS." ChemAIRS is a platform where AI, equivalent to skilled chemists with over 10 years of experience, can automatically propose complex synthesis routes in just a few minutes. It enables the identification of chirality introduction risks, prediction of side reactions and impurities, and the design of highly feasible routes considering raw material availability, yield, and cost. Additionally, it seamlessly integrates with Chemaxon's "Design Hub," for which Patcore serves as the exclusive domestic distributor, accelerating the DMTA cycle in a one-stop manner. Currently, we are accepting applications for a two-week free trial. For more details about the product and to apply, please contact us through Patcore Inc.'s official website. ▶ Two-week free trial now available Try out its capabilities with the challenges in your research lab. ▼ ChemAIRS product page: https://patcore.com/product/chemairs

Excelra has announced a partnership with Patcore to provide Japanese customers access to Excelra's scientific data and analytics products. Excelra is one of the world's leading companies in data and digital insights. Its GOSTAR platform is the largest manually curated medicinal chemistry information database, offering comprehensive and structured SAR (structure-activity relationship) data on over 9 million compounds. Excelra's GOBIOM includes the most extensive manually curated collection of verified and estimated biomarkers, providing critical insights into the relationship between biomarkers (biological indicator compounds) and diseases. Patcore is a highly specialized informatics company that supports researchers in the life sciences and chemical industries. This partnership leverages Patcore's strengths, which include experience working with some of Japan's largest pharmaceutical companies, biotechnology firms, chemical companies, and government agencies, to support Excelra's growth in Japan. For more details, please visit our website at the link below.

Currently, our regulatory substance assessment software, "CRAIS Checker," is widely used by many companies in Japan and is set to make its overseas debut with a new specification following its adoption in the Pistoia Alliance CSCS Project. In the global arena, the movement towards compliance with chemical substance management regulations has become increasingly stringent, and pharmaceutical companies have been struggling with the complex regulations that vary by country. In response, the Pistoia Alliance launched the Controlled Substance Check Service (CSCS) project last year, aiming to provide a global regulatory information source within a single system. Our company, in collaboration with our partner ChemAxon, applied for the development of this system and has now been officially selected for adoption. This recognition is based on our extensive track record and operational know-how in Japan, and we sincerely thank all the domestic users who have helped us develop our products thus far.

As incidents related to dangerous drugs continue to emerge as a social issue, the Ministry of Health, Labour and Welfare has introduced "comprehensive designation," which categorizes substances with similar structural components as illegal drugs. This includes strengthening regulations on the manufacture and sale of designated drugs, as well as prohibiting possession and use. Additionally, Tokyo, which has its own drug regulations, is also strengthening penalties under the "Tokyo Ordinance on the Prevention of Drug Abuse." For pharmaceutical and chemical companies that handle various chemical substances daily, it has become essential to verify the latest legal regulations concerning the chemicals they intend to handle before taking any action. However, the increasing regulatory burden raises the risk of overlooking regulatory information. The CRAIS Checker, which rapidly determines the regulatory status of chemical substances based on their structural formulas, addresses recent regulations that are difficult to manage through investigations of CAS numbers or lists of regulated substances, thereby supporting quicker and more reliable compliance responses. Furthermore, our regulatory substance check technology has been selected as a solution for regulatory drug compliance by the non-profit organization Pistoia Alliance, and we also offer a "Compliance Checker" that complies with drug regulations in North America, various European countries, and India, which is available in the global market.

Japan Tobacco Inc. is using the chemical information platform from ChemAxon, and a case study has been published by Fujitsu, which provided support for the system implementation. Please see the link for more details.

There are various regulations regarding chemical substances from the perspective of safety guarantees, but in legal terms, they are primarily regulated by substance names, making it difficult to determine them from chemical structures. Additionally, for organizations handling chemical substances, proper management of regulated chemicals is one of the important compliance issues. However, the diversity of regulated compounds and the fact that many organizations handle a wide variety of chemicals require considerable effort to address these issues. The regulatory compliance check system "CRAIS Checker" was developed to solve such problems and has been used by approximately 2,000 users in pharmaceutical and chemical companies, making it the largest regulatory substance check system in the country. Recently, it has been introduced to the National Institute of Health Sciences, a public institution.

Tokyo Chemical Industry Co., Ltd. and Patcore Co., Ltd. have entered into a contract for the regulatory substance check system "CRAIS Checker." The possession and proper handling of regulated substances such as narcotics, psychotropic drugs, poisons, and hazardous materials are required by law to be accurately monitored. Reagent manufacturers need to provide regulatory information about their reagents to various companies, and they have been conducting regulatory checks through a stringent check system. However, in recent years, the number of regulated substances has been increasing year by year, and the complexity of laws and regulations has necessitated more careful verification of regulatory compliance. This time, Tokyo Chemical Industry has adopted the regulatory check system "CRAIS Checker" to further enhance its checking processes. Additionally, "CRAIS Checker" will be provided as a cloud service, significantly reducing hardware investment and operational burdens compared to installing the system in-house.

Daiichi Sankyo Co., Ltd. and Patcore Co., Ltd. have concluded a contract for the domestic site license of the regulatory substance check system "CRAIS Checker." The possession and proper handling of regulated substances such as narcotics, psychotropic drugs, and toxic substances are legally required to be accurately monitored. Pharmaceutical research necessitates the handling of a wide variety of chemical substances, and the effort and time required to confirm the regulatory status of these substances within a company is considerable, which is recognized as an issue that pharmaceutical companies need to address. Additionally, the number of regulated substances is on the rise each year, making it essential to quickly capture this information and provide feedback within the company, thus creating a demand for a reliable IT system. To address these issues, Daiichi Sankyo has introduced "CRAIS Checker," and researchers at the company's development center will utilize "CRAIS Checker." "CRAIS Checker" is a system that determines the regulatory status based on chemical structures, which can express chemical substances universally, and it complies with numerous regulations, including the Narcotics and Psychotropics Control Act and the Poisonous and Deleterious Substances Control Act.

Recently, the CRAIS Checker, a regulatory substance check system, has been introduced into the reagent management system of the RIKEN (The Institute of Physical and Chemical Research). This system will be integrated into RIKEN's reagent management system. Proper management of reagents is required based on laws and regulations governing chemical substances such as narcotics, stimulants, and poisons. However, in research institutions that handle a wide variety of compounds, a significant amount of effort has been needed to determine compliance with the latest laws and regulations. The CRAIS Checker is a system that instantly determines the compliance status of regulatory substances from the structural formulas, which are a universal notation method for chemical substances, and it has a proven track record in pharmaceutical and chemical companies.

Patocoa Co., Ltd. (Headquarters: Chiyoda-ku, Tokyo) has introduced the reagent management system "CRAIS Reagent" and the regulatory compound check system "CRAIS Checker" to Sumitomo Dainippon Pharma Co., Ltd. (Headquarters: Chuo-ku, Osaka). These systems have been implemented in all research laboratories handling reagents at Sumitomo Dainippon Pharma and have been in full operation since January 2013. They are expected to strengthen the compliance framework regarding chemical substances, centralize the processes from reagent purchase to disposal, reduce expenses related to reagents, and improve the purchasing flow through integration with the purchasing system.

Patcora Inc. (CEO: Akihiro Nakamura, Headquarters: Chiyoda, Tokyo) will launch "QuickPat," a patent specification drafting support system commercialized based on a patent specification experimental item creation support system developed by a major domestic pharmaceutical company. This system enables the reduction of the diverse work time required for creating patent specification experimental items to less than about one-third (※), contributing to the acceleration of new drug research and development. The system utilizes internal information assets such as electronic notebooks and compound/active databases to create drafts of experimental items, significantly shortening the time required for drafting patent specification experimental items. Additionally, various checking mechanisms allow for the creation of accurate and robust experimental items. Along with the sale of this system, integration services will be provided to connect the electronic lab notebooks of implementing companies and reflect their patent specification drafting policies. Patcora is focused on the chemical information systems business and aims to contribute to the acceleration of new drug research and development through highly specialized solutions. (※) Based on the experiences of existing users from surveys; results may vary by case.

Patcoare Inc. (Headquarters: Chiyoda, Tokyo; CEO: Akihiro Nakamura; hereinafter referred to as "our company"), which specializes in chemical information systems, has received the "Japan Bio Venture Encouragement Award" at the "10th Japan Bio Venture Awards" hosted by Fujisankei Business Eye (Nihon Kogyo Shimbun). The Japan Bio Venture Awards aim to contribute to the promotion of industry in our country by recognizing innovative research results, promising business models, and novel and innovative bio-related equipment and systems. This award is a recognition of our company's business model for the "CRAIS Checker," a regulatory substance check system based on chemical structural formulas, which was the first of its kind to be commercialized in the world.