We will be exhibiting at the "30th Annual Meeting of the Japanese Society for Cancer Immunology" to be held in Takamatsu City from July 22 (Wednesday) to July 24 (Friday), 2026. During the luncheon seminar on July 23 (Thursday), we will invite Dr. Yuta Mishima, Assistant Professor at the University of Tsukuba, Faculty of Medicine, to give a presentation titled "Construction of a 3D Cancer Model Using iPS Cell-Derived Endothelial Cells to Enable Evaluation of Cancer Immunotherapy." At our booth, we will showcase Sartorius' portfolio that accelerates cancer immunology research, including the new iQue5 HTS Cytometer, the Incucyte Live Cell Analysis System, and newly added transfection reagents to our lineup. We look forward to your visit! Exhibition Booth: Sunport Takamatsu 1F Exhibition Hall Luncheon Seminar: Date: July 23, 2026 (Thursday) 12:10-13:00 Title: Construction of a 3D Cancer Model Using iPS Cell-Derived Endothelial Cells to Enable Evaluation of Cancer Immunotherapy Speaker: Dr. Yuta Mishima Assistant Professor, Faculty of Medicine, University of Tsukuba, Transborder Medical Research Center (TMRC) Clinical Medicine Division, Cancer Immunotherapy / Regenerative Medicine Promotion Office, Tsukuba University Hospital

We will be exhibiting at the 26th Annual Meeting of the Japanese Society for Protein Science, which will be held from June 17 (Wednesday) to June 19 (Friday), 2026, at the Tottori Cultural Center in Tottori City, Tottori Prefecture. At this meeting, we will showcase the BLI biomolecular interaction analysis system, Octet R8e, and introduce the latest application examples and usage methods. Experience the easy setup and shutdown of Octet BLI, its high throughput, and the analysis of measurement data. We also welcome inquiries about measurement workflows, so please stop by our booth (Booth Number: Lobby [8]). Additionally, we will have a lecture by Professor Katsumi Maenaka from Hokkaido University Graduate School of Pharmaceutical Sciences on the forefront of compound screening and antibody binding analysis. [Exhibition Booth] Lobby 8 [Luncheon Seminar] Date: June 17, 2026 (Wednesday) 11:25-12:15 Theme: The Forefront of Compound Screening and Antibody Binding Analysis Location: Venue C (Small Hall) We look forward to your visit!

In the QC field, ensuring the reliability and efficiency of sterility testing is always required. On the other hand, traditional sterility testing often reveals issues such as human errors, the burden of record management, and risks stemming from intervention operations. In this seminar, we will introduce how our Sterisart Universal Pump, 4th generation, addresses these challenges. Additionally, we will present Sartorius's comprehensive microbial quality management products. In environmental monitoring (process management in pharmaceutical manufacturing), we will briefly introduce the concept and operational examples of continuous monitoring in accordance with EU GMP Annex 1, as well as peripheral approaches such as the new Cyclus rapid microbial test kit. We hope you will join us!

We will be exhibiting at the "99th Annual Meeting of the Japanese Society for Bacteriology" from March 20 to 22. At this meeting, we will introduce Sartorius solutions that support the reproducibility of bacterial research. We will showcase tools that support environmental monitoring and sample preparation, focusing on the Cyclus series, which meets the new standards for mycoplasma detection. Booth number: 3 Exhibited products: ■ Cyclus Beads Extraction Kit - New product! Currently available for preview! 1. DNA extraction using magnetic beads, compatible with manual/automated workflows 2. Stable at room temperature for 2 years, contains 100 reactions 3. Extracts total nucleic acids (DNA/RNA) in one go 4. Compatible with major automation platforms ■ Cyclus Mycoplasma PCR Kit - Coming soon! 1. Mycoplasma PCR kit compliant with revised EP 2.6.7 (100 GC/mL) 2. Simultaneous detection with FAM (target) / HEX (IC), setup takes about 15 minutes at room temperature 3. Compatible with common real-time PCR devices We will also have many other Sartorius lab products on display! We look forward to your visit!

We will be exhibiting at the "4th Annual Meeting of the Japanese Society for Antibody Research" held at Omiya Sonic City from December 1 to 3. At our booth, we will showcase the Octet R8e biomolecular interaction analysis system. On the first day, we will host a tea time seminar featuring Professor Noriko Yamano-Adachi from Osaka University. We invite you to stop by! **Booth** Omiya Sonic City, Exhibition Hall 1 **Tea Time Seminar** December 1 (Monday) 15:05 - 15:35 Omiya Sonic City, Exhibition Hall 5 **Speaker:** Associate Professor Noriko Yamano-Adachi Department of Bioengineering, Graduate School of Engineering, Osaka University **Title:** Measurement of the affinity of antibodies produced in different host cells and antibodies with different higher-order structural characteristics against antigens **Abstract:** CHO cells are still used as the standard host for biopharmaceutical production. We observed structural changes in antibodies associated with culture and confirmed the transition from a closed structure to a Y-shaped structure. This presentation will introduce the affinity analysis results obtained using the Octet system and examples of its applications.

Organoid technology requires reliable culture and analysis methods for applications in research and drug screening, and conventional methods face challenges due to limitations in the objective monitoring of 3D structures. In this regard, the organoid analysis application of the live cell analysis system Incucyte automates workflows, tracks and quantifies growth and morphology in real-time, and streamlines analysis and culture optimization, making it a powerful tool across a wide range of fields. In this seminar, we will present the latest information, including assay results using 96-well plates, in addition to the QC evaluation content introduced in the previous webinar. We will also explain the recognition and recovery methods for organoids using the automated cell imaging and picking device CellCelector, showcasing Sartorius's total solution that achieves an efficient workflow in combination with Incucyte. We look forward to your participation! Instructors: Sartorius Japan K.K. Takeshi Seguchi, Shohei Shimonishi Application deadline: November 7, 2025 (Friday) by 17:00.

In recent years, particularly due to the outbreak of the novel coronavirus, there has been a strong demand for the rapid development of vaccines, diagnostic methods, and research on therapeutic drugs for infectious disease control. To accelerate the development of therapeutic drugs and vaccines, high-throughput screening from many candidates and analytical instruments capable of more accurate and rapid characterization are necessary. The Octet system can measure binding interactions between biomolecules in unpurified samples. With its unique BLI technology and the design of instruments that allow simultaneous measurement of multiple samples, it enables high-throughput screening of candidate molecules, evaluation of binding characteristics, and concentration measurement. It is widely used not only in the development of therapeutic drugs and vaccines but also in research on fundamental infection mechanisms. In this seminar, we will introduce examples of the application of the Octet biomolecular interaction analysis system in the research and development of therapeutic drugs and vaccines, as well as research cases that contribute to understanding fundamental infection mechanisms. We hope you will join us! Instructor: Sartorius Japan K.K. Yusuke Maruyama Application deadline: By 17:00 on November 14, 2025 (Friday)

Sartorius Japan will hold "Pharma Xchange 2025" with the theme of the latest trends in pharmaceutical quality control (QC) and compliance measures. This seminar will deepen the understanding of regulatory requirements and introduce specific support measures for ethical practices across the industry. In addition to a lecture by Dr. Yukihiro Goda, a demonstration of Sartorius QC solutions is also planned. We look forward to your participation! Event Overview: Date: October 17, 2025 (Friday) 13:30 - 18:30 Venue: Station Conference Tokyo, Sapia Tower 6th Floor 1-7-12 Marunouchi, Chiyoda-ku, Tokyo 100-0005, directly connected to JR Tokyo Station Nihonbashi Exit Participation Fee: Free Eligibility: Individuals belonging to the pharmaceutical quality control department, engaged in related work, or interested in JP revisions. *Up to two participants per department from each company will be accepted on a first-come, first-served basis. If you wish to participate, you can apply using the form at the bottom of the details and application page. *Due to limited seating, please apply by September 22, 2025 (Monday).

We are pleased to announce that Sartorius Japan has launched the new product, the Octet R8e BLI Biomolecular Interaction Analysis System. The Octet R8e offers higher sensitivity, longer automatic measurement times, and flexible throughput compared to previous models, providing excellent performance and reliability. We will be holding a product launch event on Tuesday, July 15, so please join us. In addition to presentations by Mr. Shigemune Kumaji from Epsilon Molecular Engineering, an Octet user, and Mr. Ryo Matsunaga from the University of Tokyo, we also have a workshop on intermolecular interaction measurements planned. We look forward to your participation! Event Overview: Date and Time: Tuesday, July 15, 2025, starting at 13:30 Venue: Hibiya Mitsui Conference (Room 1, 8th Floor, Tokyo Midtown Hibiya) Participation Fee: Free Capacity: 40 people (Registration will close once capacity is reached) If you wish to participate, you can apply using the form at the bottom of the details and application page.

At the Dialogue 20th Anniversary "PHARMA & BIOTECH 2025," we will be sponsoring with an exhibition and seminar featuring Sartorius products! This seminar is organized by Dialogue and will feature presentations and poster sessions over two days, focusing on various modalities in drug discovery, primarily for pharmaceutical companies. Sartorius will have an exhibition booth for two days, showcasing the Octet biomolecular interaction analysis system, Incucyte live cell analysis system, and iQue HTS cytometer. Additionally, on Tuesday, August 5, we will present "Cross-platform analysis of binding and function of anti-HER2 antibody-drug conjugates (ADCs)." We hope to see you there! *Please select "Sartorius Japan" as the source of your knowledge about the site.

On July 5, 2024, we will provide on-demand streaming of the recorded seminar given by Professor Kazutaka Tsujikawa from Osaka University at our luncheon seminar during the 51st Annual Meeting of the Japanese Society of Toxicology, available for a limited time. We encourage you to register and watch. Title: Support for Life Sciences and Drug Discovery Research by AMED BINDS at the Drug Discovery Science Research Support Center, Osaka University, and the Utilization of Incucyte Abstract: The AMED Life Sciences and Drug Discovery Research Support Infrastructure Project (BINDS) is a research support initiative aimed at connecting the results of Japan's outstanding life sciences research to drug discovery and development. At the Drug Discovery Science Research Support Center of Osaka University, we have established a system to seamlessly support advanced equipment setup and utilization, exploration of drug discovery target molecules, provision of compound libraries, implementation of high-throughput screening, and structural development of compounds as well as in vivo pharmacokinetics and safety testing, following the acceptance of BINDS. This seminar will introduce examples of the use of Incucyte in toxicity evaluations utilizing spheroids and organoids, along with these distinctive support features. Viewing Period: December 17, 2024 – January 17, 2025

The Sartorius Life Science Academy 2024, which was scheduled to be held in August, has now been changed to an online format. In this session, Mr. Shunsuke Kitajima from the Cancer Research Institute of the Public Interest Incorporated Foundation and Mr. Hideya Sakaguchi from the RIKEN Center for Biosystems Dynamics Research will discuss application examples of our Incucyte live cell analysis system in their respective research. Please see below for the abstracts and program. Additionally, our application scientists will also introduce new applications of Incucyte. We hope you will join us.

We will be exhibiting at the "76th Annual Meeting of the Japanese Society for Biotechnology" held at the Tokyo Institute of Technology, Ookayama Campus from September 8 to 10. At our booth, we will showcase the Octet biomolecular interaction analysis system. On the second day of the conference, we will host a luncheon seminar featuring Dr. Akiyo Kato from Nagoya University. We hope you will stop by! **Booth** Booth Number: West Building 9, 1F - 14 **Luncheon Seminar** September 9 (Monday) 11:30 AM - 12:30 PM 2L-B (Venue B, West Building 9, W9-324) Speaker: Dr. Akiyo Kato Graduate School of Bioagricultural Sciences, Nagoya University Title: Production of Fab Antibodies by Microorganisms and Case Studies of Affinity Measurement Using Trace Samples Abstract: In our laboratory, we are developing techniques for the production and evaluation of single B cell-derived monoclonal antibodies using an E. coli cell-free protein synthesis system, as well as methods for large-scale production of Fab antibodies utilizing recombinant production systems by microorganisms. In this presentation, I would like to mainly introduce case studies of BLI method analysis using trace samples, including affinity analysis of Fab antibodies produced in microbial systems, analysis using solutions of difficult-to-purify or unidentified antigens, and affinity analysis between proteins and DNA.

We are pleased to announce that Sartorius Japan Co., Ltd. will be exhibiting at JASIS 2024, which will be held from September 4 (Wednesday) to September 6 (Friday) for three days. We plan to showcase a variety of products including pipettes, electronic balances, ultrapure water production systems, and filters. We will also participate in a new technology presentation, so please stop by. Venue: Makuhari Messe International Exhibition Hall Booth Number: 8B-405 Participation Fee: Free 【Highlights of the Exhibition】 - Laboratory Balance Quintix Pro - Electronic Pipette Picus 2 - Alium Mini Compact Ultrapure Water Production System - Universal Pump Sterisart for Clean Environments 【New Technology Presentations】 - September 5 (Thursday) 10:30-11:00 (Makuhari Messe Conference Room 104) Introduction of the next-generation electronic pipette that provides comfortable pipetting (OPEN API compatible) - September 6 (Friday) 15:00-15:30 (TKP (formerly APA) Venue No. 9) Introduction of the new Sartorius Semi-Micro Balance (Innovation in work efficiency due to a significant leap in measurement time)

The micro pipette is eligible for trade-in, and you can send in the eligible items to purchase the same number of Picus2 at a special price. Eligible trade-in items: Piston-type micro pipettes (regardless of manufacturer) * No restrictions on the number of channels or capacity * No restrictions on electric or manual types * No restrictions on the condition of the main unit Eligible models for purchase: Electric pipette: Picus2 Please send the trade-in items to the above address within two weeks from the application date. If the dedicated application form and the trade-in pipette cannot be confirmed, your order will be subject to cancellation. If there are circumstances preventing you from sending the items, please consult with us. For inquiries regarding this campaign, please contact: Email: info.lps@sartorius.com

We will participate in the online seminar "Cell Culture Technology 2024" hosted by DialoG Co., Ltd. We will provide various information on the latest trends in cell culture technology. Our company will present on the topic "The Importance of Continuous Image Evaluation from Screening to QC." Please be sure to register! *When registering, please select "Sartorius Japan" as the source of how you learned about the site. Date and Time: April 25, 2024 (Thursday) From 13:00 (scheduled) Format: Online Participation Fee: Free (up to 200 participants) Capacity: 250 participants Deadline: Until 17:00 on April 18, 2024 (Thursday) *Registration will close as soon as the capacity is reached. [Our Seminar] Title: The Importance of Continuous Image Evaluation from Screening to QC Speaker: Shohei Shimonishi (Field Application Scientist, Sartorius Japan Co., Ltd.)

The Octet system has a proven track record not only in kinetics analysis but also in the specific quantitative measurement of biomolecules based on Binding Rate. Compared to ELISA and HPLC, it allows for simple, quick, and highly accurate quantitative measurements. Octet quantitative analysis for screening expression libraries, optimizing culture conditions, and checking purifications contributes to the simplification of processes in biopharmaceutical development, enabling the acceleration of the entire development flow. If you wish to view the On-Demand Webinar, please fill in your customer information from the "Details & Application" link below. After completing your application, the On-Demand viewing link will be displayed on the screen. The webinar presentation slides can be downloaded from the related catalog below.

Zaltrius has launched the Octet R series, a modular label-free real-time biomolecular interaction analysis system. It can be upgraded to meet future throughput demands, which helps to reduce initial costs. The Octet series employs a bio-layer interferometry method that does not require microfluidics, making maintenance easy, improving lab productivity, reducing costs, and shortening experimental timelines.

The World Health Organization (WHO) recognized on March 11, 2020, that the novel coronavirus (COVID-19) infection had reached a pandemic level. Currently, there is a demand for the acceleration of research on treatments and vaccine development for this infection. To expedite the development of therapeutics and vaccines, advanced analytical techniques are crucial for rapid screening of many candidates and for determining the most promising candidates. The Octet system enables real-time assays of biomolecular interactions using BLI technology and allows for high-throughput screening and evaluation of candidates through simultaneous measurement of multiple samples. As a result, data from the Octet system has been featured in many papers that bring breakthroughs related to the biological research of COVID-19 and vaccine and therapeutic development. ■ Ended (2020/10/20) 【Update Information】 If you wish to view the webinar, please fill in your customer information from the "Details & Application" link below. After completing your application, an On-Demand viewing link will be displayed on the screen. The webinar presentation slides can be downloaded from the related catalog below.

One of the most important steps in the antibody development workflow is how to efficiently screen excellent antibodies from a large number of antibodies produced using immunological methods and phage display methods. The conventional ELISA method, which analyzes based on affinity, cannot distinguish between clones that express low-affinity antibodies at high levels and clones that express high-affinity antibodies at low levels; therefore, methods that analyze based on kinetic information become effective. The Octet system enables the identification of clones that produce high-affinity antibodies, which is considered difficult with the ELISA method. Obtaining kinetic information at an earlier stage in the development of antibody drugs and diagnostic agents can lead to the simplification of subsequent processes and accelerate the entire development flow. ■ Completed (2020/11/17) 【Update Information】 If you wish to view the webinar, please fill out your customer information from the "Details & Application" link below. After completing your application, an On-Demand viewing link will be displayed on the screen. The webinar presentation slides can be downloaded from the related catalog below.

The characterization analysis of the epitope regions of target proteins can determine whether multiple clones share the same epitope or recognize different regions of the target protein, providing detailed information for antibody development. Epitope binning, which classifies antibodies based on the antigen regions or epitopes they bind to, is an effective assay for the development of antibody drugs and diagnostic agents. The Octet system enables high-throughput epitope binning assays through real-time assays of biomolecular interactions and simultaneous measurements across multiple channels, accelerating antibody development. In this seminar, we will provide an overview and explanation of the usefulness of epitope binning assays, as well as examples of applications using the Octet system. ■ This has concluded (2020/9/29) 【Update Information】 If you wish to view the webinar, please fill in your customer information from the "Details & Registration" link below. After completing your registration, an On-Demand viewing link will be displayed on the screen. The webinar presentation slides can be downloaded from the related catalog below.

The "Incucyte Live Cell Analysis System" has been awarded the Platinum Seal of Quality from SelectScience (a recognition for reliable and high-quality products). As a criterion for evaluation, only the top 0.1% of lab products that consistently receive high customer reviews are eligible for the award. Incucyte is a system that enables non-invasive and rapid analysis, overturning conventional wisdom about cultured cells. It allows for the real-time measurement of dynamic changes and interactions of live cells while they are maintained in an incubator, unaffected by external environmental influences, and generates rich analytical data almost automatically and instantaneously. Additionally, the remote access feature allows for monitoring of experiments and data at any time.

Regarding the ForteBio seminar that has been held annually, in light of the trends related to the COVID-19 pandemic, we have prioritized the health and safety of participants and stakeholders, and as a result, we have decided to cancel the event for the fiscal year 2020. We sincerely apologize for the inconvenience caused to those who were considering participating this year. We will continue to prepare for the event in fiscal year 2021, and we appreciate your continued consideration for participation. Additionally, we will be conducting an application seminar in an online format for the fiscal year 2020. Please refer to the announcement for the ForteBio Webinar 2020 for more details.

We have received great feedback from everyone regarding the Sartorius QMS Seminar, which we have held every year. However, in light of the trends related to the COVID-19 pandemic, we have prioritized the health and safety of participants and stakeholders, and as a result, we have decided to cancel the event for 2020. We sincerely apologize for the inconvenience caused to those customers who were considering participating this year. We will continue preparations for the event in 2021, and we appreciate your continued consideration for participation.

【A Must-See for Those Troubled by Clogging!】 Introducing the new Sartoclear DY series, which filters in a sterile manner in one step. ■ One-step filtration using diatomaceous earth eliminates the need for centrifugation. ■ Essential for those facing clogging issues, as well as for antibody production, protein expression, and virus culture! ▪ Filtration proceeds without clogging thanks to the properties of diatomaceous earth. ▪ Cell culture supernatant can be filtered while still containing cells. ▪ No need for centrifugation before sterilizing filtration (1 step), saving time and unnecessary costs. ▪ Applicable volume ranges from 10 mL to 1 L. Note: Cells cannot be recovered for reuse. *Samples/Demo requests are welcome. Please feel free to contact us.

Zaltrius has collaborated with biopharmaceutical companies as a supplier in the development and manufacturing of vaccines in response to outbreaks and pandemics of infectious diseases such as Ebola, Zika, and H1N1 over the past decade. Zaltrius's experience and solution portfolio will support customers at all stages of vaccine development against the novel coronavirus SARS-CoV-2 outbreak, from discovery to testing and large-scale manufacturing. We provide solutions to help you manage various risks in vaccine development and manufacturing while maintaining speed, quality, and flexibility in emergency situations.

The evolved version of the single-use bioreactor system "Biostat STR" series, designed for rapid process development and seamless scale-up to commercial production, has arrived. The latest version, "Biostat STR Generation 3," is equipped with a new automation platform "BIOBRAIN" and the analytical tool "BioPAT(R)." This enables exceptional speed, quality, and productivity. The speed, quality, and productivity from process development to upscaling in your pharmaceutical manufacturing scene will dramatically improve. A stable, predictable, and robust process greatly contributes to providing safe and reliable biopharmaceuticals to patients worldwide, further accelerating your manufacturing operations and business. Please take a look at the details of this outstanding product and its stylish design!

The new Microsart ATMP Fungi Detection Kit has been announced. It detects bacterial and fungal contamination in just 3 hours, compared to the 14 days required by traditional methods. Previously, it only detected Mycoplasma and Bacteria, but with the addition of Fungi, it has become a much more powerful tool. Additionally, a new Sterility Release kit has been introduced, which includes the Bacteria kit, Fungi kit, and DNA extraction kit.

In response to the spread of the novel coronavirus infection, Sartorius Japan will continuously inform you about the measures we are taking. Information on novel coronavirus measures https://sartorius-if.smktg.jp/public/seminar/view/218

Sartorius Stedim Japan Co., Ltd. has decided to actively withdraw from participation in the "Regenerative Medicine EXPO Osaka" (Intex Osaka) scheduled to be held from February 26, considering the health and safety of participants and stakeholders in light of the ongoing spread of the novel coronavirus infection. Although we will have a booth prepared, we will not be displaying products and will provide unmanned support. As a result, all seminars related to the following products and technologies, which would gather a large number of participants, will be canceled. We sincerely apologize to those who were hoping to attend and ask for your understanding in this matter. Additionally, information and catalogs regarding the seminar-related products and services can be viewed below. If you are interested, please feel free to contact us. ▼ Canceled Seminars February 26 (Wed) 11:00–11:30 Manufacturing and Process Development of Viral Vectors February 28 (Fri) 11:00–11:30 Testing Packages for Cell Therapy and Gene Therapy ■ Contact Information Representative: 03-6478-5201 hp.info@SARTORIUS.com