Analysis of FcRn-Antibody Interactions Technical Document
Accurately evaluate the FcRn-IgG binding that affects the half-life extension of antibodies! Introducing assay design and best practices.
This document is an application note summarizing the analysis method for FcRn-antibody interactions using the "Octet" biomolecular interaction analysis system. The binding of the Fc region of human IgG antibodies to the neonatal Fc receptor (FcRn) affects the biological and pharmacological properties of antibodies, such as extending the half-life. By altering this binding, it is possible to extend or shorten the serum half-life of Fc-containing therapeutics, which can impact the efficacy of the drug. It includes recommendations on the selection of biosensors, assay optimization, data collection, curve fitting, and methods for result analysis. [Contents (partial)] ■ Introduction ■ Octet platform for FcRn-antibody interaction analysis ■ Selection of biosensors and assay direction ■ Assay optimization ■ Data analysis ■ Intra-assay and inter-assay precision *For more details, please download the PDF or feel free to contact us.
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【Other Published Content】 ■Quality of Reagents ■Assay Buffer ■Optimization of Ligand Immobilization ■Analyte Concentration ■Non-Specific Binding ■Referencing *For more details, please download the PDF or feel free to contact us.
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