We would like to invite you to the second seminar where researchers involved in the Schrödinger drug discovery research project will introduce examples of computational chemistry drug discovery and provide an opportunity for questions and answers from the audience. We welcome broad participation from those who are interested in the latest technologies in quantitative simulation, the further efficiency of the DMTA (Design-Make-Test-Analyze) cycle enhanced by experimental validation, and those who are eager to engage in next-generation drug discovery research. ■ Theme of the Second Seminar In Silico Driven Drug Discovery of a Zwitterionic Integrin αvβ6 Development Candidate for Fibrosis ■ Speaker Aleksey Gerasyuto Vice President, Drug Discovery, Head of Chemistry, Schrödinger Therapeutics Group *Participation from other companies in the same industry is discouraged.

Schrödinger, Inc. will be exhibiting at the 11th Kansai Plastic Japan. *Exhibition Information* Exhibition Name: 11th Kansai Plastic Japan within Kansai High-Performance Materials Week Dates: May 17 (Wednesday) to May 19 (Friday), 2023, 10:00 AM to 5:00 PM Venue: Intex Osaka, Hall 6B Booth Number: 7-44 *Schrödinger Seminar Information* Location: Our exhibition booth Themes: 1. Research DX Platform LiveDesign that accelerates new material development Execute predictions the moment ideas are input! Enabling effective material development. Session Times: 10:30, 11:30, 1:00, 2:00, 3:00, 4:00 2. Material development through atomic-level simulations and machine learning Enabling predictions of physical properties of various materials on a computer. Case studies will be presented. Session Times: 11:00, 12:00, 1:30, 2:30, 3:30, 4:30 Please feel free to stop by!

Computational chemistry design methods in drug discovery are establishing their presence as one of the essential foundational technologies in the field. Since its founding in 1990, Schrödinger has continuously worked to enhance software and informatics for molecular design, providing practical solutions for pharmaceuticals and chemical materials. By leveraging its own simulation technologies and informatics infrastructure, Schrödinger has demonstrated a track record of efficiently producing high-quality drug designs in numerous drug discovery research projects. This seminar will feature researchers involved in Schrödinger's drug discovery projects presenting real-world examples of computational chemistry in drug discovery. ■ Theme of the First Session Developing potent and selective kinase inhibitors using at-scale FEP and protein FEP: a Wee1 case study ■ Speaker Jennifer Knight, Ph.D., Director, Schrödinger Therapeutics Group *Participation from competing companies is not permitted.

Schrödinger Inc. will be exhibiting at the 24th Electronic Components and Materials Expo (January 25-27, Tokyo Big Sight). *Exhibition Information* Exhibition Name: 24th Electronic Components and Materials Expo Dates: January 25 (Wednesday) to 27 (Friday), 2023, 10:00 AM to 5:00 PM Venue: Tokyo Big Sight Booth Number: 19-30 We warmly invite you to visit us.

Schrödinger, Inc. will hold a luncheon seminar at the 39th Medicinal Chemistry Symposium (online). 【Date and Time】 November 25 (Friday) 11:50 - 13:10 Venue: Online Session ID: LS8 【Program】 Digital Chemistry: The World of Medicinal Chemistry Realized by the Schrödinger Platform Hideyuki Sato (Schrödinger, Inc.) Please refer to the attached PDF for the abstract.

Schrödinger, Inc. will be presenting oral presentations and exhibiting at the 35th Organic EL Discussion Meeting from November 24 (Thursday) to 25 (Friday). 【Company Exhibition Advertisement】 Date and Time: November 25, 17:15-17:40 Title: "A Platform for Molecular Simulation and Machine Learning Supporting the Development of New Organic EL Materials: Materials Science Suite" 【Simulation Short Oral Presentation】 Date and Time: November 26, 13:10 Title: "Molecular Structure Search of Hole Transport Materials Using Genetic Algorithms with Machine Learning Models for Evaluation Functions" We look forward to your visit.

Schrödinger Inc. will be presenting a poster and exhibiting at the 31st Polymer Materials Forum from November 15 (Tuesday) to November 16 (Wednesday). [Poster Presentation] Date: November 15 (Wednesday) at 14:00 Title: "Calculation of Frequency Dependence of Dielectric Constant and Dielectric Loss Tangent of Glassy Polymers by Classical Molecular Dynamics Simulation" We hope to see you there!

Schrödinger Inc. will be exhibiting at the 3rd AI & Artificial Intelligence Expo [Autumn] (October 26-28, Makuhari Messe). *Exhibition Information* Exhibition Name: 3rd AI & Artificial Intelligence Expo [Autumn] Dates: October 26 (Wednesday) - 28 (Friday), 2022, 10:00 AM - 5:00 PM Venue: Makuhari Messe Booth Number: 9-12 We warmly invite you to visit us.

At the CBI Society 2022 Annual Meeting, we will hold a luncheon seminar as Schrödinger, Inc. In this seminar, titled "Latest Information on the High-Precision Free Energy Calculation Method FEP+ Leading the Digitalization of Drug Discovery Research Flow," we will introduce the scalability of FEP+ and its application in drug discovery research. We will also have an exhibition booth, so please feel free to stop by. 【Date and Time / Location】 CBI Society 2022 Annual Meeting Schrödinger Luncheon Seminar LS-06 October 26 (Wednesday) 12:00 – 13:30 Venue: Tower Hall Funabori, Heian 【Program】 Latest Information on the High-Precision Free Energy Calculation Method FEP+ Leading the Digitalization of Drug Discovery Research Flow Hideyuki Sato (Schrödinger, Inc.) Please refer to the attached PDF for the abstract.

Schrödinger, Inc. will be exhibiting at the 2nd [International] Secondary Battery Expo - 2nd Smart Energy Week [Autumn] (August 31 - September 2, Makuhari Messe). * At our exhibition booth, we will hold short seminars on battery development using the 'Materials Science Suite' and materials informatics utilizing 'LiveDesign.' Additionally, you will have the opportunity to experience each software firsthand. * Exhibition Information Exhibition Name: 2nd [International] Secondary Battery Expo - 2nd Smart Energy Week [Autumn] Venue: Makuhari Messe Booth Number: E13-13 We invite you to visit us!

Schrödinger, Inc. will hold a materials science web seminar titled "Schrodinger Materials Science Seminar Japan Summer 2022" from July 26 (Tuesday) to July 29 (Friday). Our company develops, sells, and provides services for software aimed at materials science, including: - The "Materials Science Suite," a simulation software platform that enables advanced analysis and property predictions at the atomic scale, - The "LiveDesign" platform for materials informatics. In the seminar, we will clearly introduce what can specifically be done using these software tools. The content will be of interest not only to those with experience in simulation and machine learning but also to those who are just starting out. We encourage you to participate freely.

Our senior scientist, Mr. Hinizaki, will give an invited lecture online at GSENN2022, held in Copenhagen, Denmark, titled "Classification of Nanostructured Materials and Extension of it to the Fractal Structures." He will propose a method for classifying complex nanostructures based on the dimensions of their substructures and extend the concept to materials with more complex fractal dimensions, such as gels. He will also discuss the modeling of complex systems for molecular dynamics using Schrödinger's Materials Science Suites, providing examples of substructures with different dimensions.

Schrödinger, Inc. will be exhibiting at the 22nd Annual Meeting of the Japanese Society for Protein Science. At our booth, you can experience advanced simulation tools, including 3D modeling of common antibodies using our integrated solution "BioLuminate" for biologics and antibody drug discovery, as well as estimation of aggregation sites that significantly impact antibody stability, affinity maturation of antigen-antibody complexes, PTM sites, and antibody developability, and prediction of antigen-antibody complex structures using protein-protein docking. Additionally, we will hold a luncheon seminar starting at noon on the 7th (Tuesday). 【Luncheon Seminar Date & Location】 June 7 (Tuesday) 12:00 - 12:50 Venue: Room E (Tsukuba International Congress Center 2F) Session ID: LS1E 【Program】 Schrödinger's approach to physics-based antibody analysis and design: dealing with disordered epitopes and very long CDR H3 loop.

Schrödinger, Inc. will be exhibiting at the "Spring Academic Conference of the Japan Society of Applied Physics" held at Aoyama Gakuin University, Sagamihara Campus (Sagamihara City, Kanagawa Prefecture) from March 22 (Tuesday) to March 26 (Saturday), 2022. At our exhibition booth, we will provide explanations of our products and services, as well as consultations regarding any challenges you may have. We look forward to welcoming researchers interested in atomic-level simulations related to semiconductor manufacturing and resin encapsulation using molecular simulation software. Please feel free to stop by!

Schrödinger, Inc. will be exhibiting at the 10th [Kansai] Plastic Japan (May 11-13, at Intex Osaka). At our booth, you can experience our unique materials development support software based on LiveDesign. Additionally, in a specialized technical seminar, Takashi Ishizaki, Strategic Deployment Manager, will give a lecture titled "Data Accumulation Platform for Utilizing Open Source in Materials Informatics" on May 11 (Wednesday) at 10:00 AM.

Our senior scientist, Mr. Hinizaki, will give a presentation titled "Utilization of the Materials Science Suite for Glass Research." Our Materials Science Suites are a major platform for Materials Science, capable of comprehensive handling of quantum mechanical calculations, molecular dynamics, and machine learning. The high-speed molecular dynamics (MD) program Desmond, which utilizes GPUs, has several panels that are useful for glass research. For initial structure creation, there are Builders such as Polymer, Crystal, Semicrystalline Polymer, and Disordered Structure, and it can also handle composite structures and mixed systems. You can set up the flow of calculations using a multi-stage MD workflow. In particular, the Thermophysical Property feature allows for easy determination of the glass transition temperature (Tg) with added controls for cooling time and convergence of density. In addition to thermodynamic quantities and structural functions, calculations such as Stress Strain and analyses of Free Volume are possible, so please utilize these for the advancement of your research.