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We will hold an introductory webinar about the toxicology information search system "ToxPlanet." ToxPlanet is an integrated search platform that encompasses toxicity/safety information for compounds. It covers toxicity databases worldwide (over 1,300 data collections, more than 700 regulatory and advisory lists, and over 10 million literature references, providing information on more than 110 million compounds), allowing for comprehensive access to toxicity information from a single search, thereby enhancing the efficiency of toxicity information and safety investigations. In this webinar, we will provide an overview of ToxPlanet and conduct a demonstration of its operation. If you have any interest, please feel free to join us.

On October 30th (15:00 to 15:30), we will hold an advanced webinar on "Multivariate Analysis Software: SIMCA" focusing on the discriminant model OPLS-DA. SIMCA is widely used in research and development settings that handle large data sets. In this webinar, we will focus on "Discrimination: OPLS-DA" and include demonstrations and case studies. ● OPLS-DA An enhanced model of PLS-DA. By rotating the axes to maximize the separation between classes, it makes discrimination between classes easier. Additionally, by utilizing the S-plot, reliable marker candidates that are difficult to identify from the loading plot can be visualized instantly. For example: * I want to explore biomarker candidates from case-control data. * I am struggling to find significant features as the T-test only reveals false positive-like factors. 【Registration】 Please register at https://form.k3r.jp/infocom_science/251030_SIMCA_webinar_a_OPLSDA. * Participation from competitors in the same industry is not allowed. * Please ensure you have the latest version of ZOOM installed.

We will be exhibiting at the 19th Metabolome Symposium. Please be sure to stop by our booth when you attend.

CASE Ultra is a type of QSAR software that can predict various toxicities such as mutagenicity, carcinogenicity, and skin/eye toxicity from the two-dimensional structural information of compounds. It has the following features: - Developed in collaboration with FDA/CDER, it can utilize over 130 types of toxicity data, including FDA's non-public data, as predictive models. - Predictions can be made using both statistical and knowledge-based models (mutagenicity, skin sensitization), and it is compatible with ICH M7. - It can perform alert-based read-across. - It allows for model enhancement and creation using proprietary data. - It has a significant track record of use in various fields such as pharmaceuticals, chemicals, food, and cosmetics, both domestically and internationally. In this webinar, we will not only provide an overview of CASE Ultra but also conduct a basic operation demo of the actual software. Participation is free, so if you have any interest, please feel free to join!

An advanced webinar on "Multivariate Analysis Software: SIMCA" (Regression Model OPLS) will be held on September 26, 2025, from 15:00 to 15:30. SIMCA is a multivariate analysis software that is well-regarded in fields handling large data sets, offering features for overview, regression, discrimination, and classification. In this webinar, we will focus on 'Regression: OPLS' and include short demonstrations and case studies (three are planned). ● OPLS: Orthogonal Partial Least Squares A superior model to PLS. By rotating so that the Y variable becomes the first axis, interpretation is made easier. This model allows for the prediction of target variables and factor analysis. Example of OPLS usage: * Set the coffee quality evaluation score as the target variable, find the factors that contribute most from the metabolic profile GC/MS data, and further predict the quality evaluation score from the GC/MS data. * While PLS was able to identify the most contributing factors, determining the second and third most contributing factors was difficult. In contrast, OPLS made this identification easy.