[Analysis Case] Risk Assessment of Nitrosamines in Pharmaceuticals
[Introduction to Ion Chromatography Cases] Measurement of Nitrite and Amines
N-nitrosodimethylamine (NDMA) is an organic compound represented by the chemical formula (CH3)2NNO. NDMA is a known carcinogen found in some fermented foods. The measurement of nitrite ions can be performed using wet chemical analysis, but a representative method in instrumental analysis is ion chromatography (IC). In IC, separation is achieved using an ion exchange column, and detection is carried out using conductivity detection, electrochemical detection, UV detection, or mass spectrometry. Methods using IC typically require little to no sample pretreatment for many pharmaceutical samples, and derivatization of the target components is also unnecessary.
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