Exploration and evaluation of Olink neurobiomarkers.
Multiplex Approach to Multifactorial Diseases: A New Era in Neurodegenerative Biomarker Research
Olink's neurobiomarker analysis is a proteomics method that allows for the highly sensitive and specific simultaneous measurement of neurodegenerative disease-related proteins from limited samples such as plasma, serum, and cerebrospinal fluid, using Proximity Extension Assay (PEA) technology. Olink Target 48 Neurodegeneration enables the absolute quantification of markers important in neurodegenerative disease research, such as Aß40, Aß42, pTau217, NfL, and GFAP, making it useful for longitudinal studies and inter-facility comparisons. Furthermore, by using Olink Explore HT and Target 96 Neurology, a broad protein profiling analysis including neuroinflammation and synaptic function becomes possible, supporting the identification of novel biomarkers and elucidation of pathological mechanisms. **Effects of Implementation** - Promotion of understanding disease mechanisms through comprehensive analysis of neuroinflammation-related proteins. - Increased efficiency in biomarker discovery and contribution to drug development research. - Ability to measure numerous proteins from a small amount of sample, allowing for effective use of valuable samples.
basic information
【Target 48 Neurodegeneration Features】 - Number of proteins: 41 (validated) - Sample volume: 1 µL (plasma, serum, etc.) / panel - Specificity: 99.5% (very little cross-reactivity) - Expression value: pg/mL absolute quantification - Reading method: Quantitative PCR (Olink Signature Q100) 【Explore HT Features】 - Number of proteins: Simultaneous measurement of over 5,400 proteins - Sample volume: 2 µL (plasma, serum, etc.) / panel - Specificity: High specificity of 99.5% - Throughput: Over 2,000 samples per week - Reading method: NPX relative quantification (next-generation sequencer) 【Our Strengths】 Thermo Fisher Scientific Inc. provides cutting-edge analytical instruments, including Olink Explore HT, as a world-leading scientific services company. Our experienced staff supports customers from the consideration of experimental design tailored to research purposes and analytical needs to equipment installation and analysis services.
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Model number/Brand name
Olink Explore HT, Target 96, Target 48
Applications/Examples of results
From cohort analyses such as the UK Biobank and SCALLOP to validation in clinical research, we can consistently conduct research from exploration to bridging studies on a single platform. It is utilized for research purposes in many fields, not only in disease research but also in healthcare related to aging, by companies, research institutions, and hospitals. It cannot be used for diagnosis. 1) Neurodegenerative Diseases: Looking Beyond the Boundaries of the Brain. (2022) Front Neurosci. 2) Emerging non-traditional biomarkers for Alzheimer’s diagnosis and progression. (2025) Ageing Research Reviews Many papers can be found on the Olink website.
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Free Online Seminar: Practical Applications from Biomarker Discovery to Clinical Use
■Connecting Biomarker Discovery to Clinical Application - Explained with Real Cases of Neurodegenerative Diseases Although biomarkers are discovered, many do not reach clinical application. The reasons for this lie in multiple hurdles that arise after discovery, such as "narrowing down candidates," "reproducibility," and "connecting to clinical practice." 1. How should promising candidates obtained from comprehensive exploration be narrowed down? 2. How can reproducibility and scalability be ensured? 3. What are the key points for smoothly transitioning to clinical research? 4. What should be considered in data science throughout the overall flow? In this online seminar, we will clearly explain specific strategies for advancing from discovery to clinical application based on actual research cases of Alzheimer's disease and multiple sclerosis, in an easy-to-understand manner in Japanese. *Olink products and services are for research purposes only. Please note that they cannot be used for diagnostic purposes.
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Accelerating Neurodegenerative Disease Research with Proteomics Webinar | Olink Use Cases and Latest Applications
This webinar will showcase the innovative impact of Olink's proteomics platform on neuroscience research and precision medicine. It will explain the advantages of large-scale protein analysis for elucidating the complex pathomechanisms of neurodegenerative diseases, early diagnosis, biomarker discovery, and accelerating drug target identification. The discussion will delve into how understanding neuroimmune interactions, brain inflammation, and regulatory pathways through proteomics technology contributes to achieving more precise and personalized healthcare. Examples of the application of Olink technology in various neurological disease fields, such as multiple sclerosis (MS), Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and Parkinson's disease, will be presented, along with contributions to the development of personalized treatment strategies and improvements in diagnostic accuracy. ▶ Title: Neuroscience Research and Precision Medicine Utilizing Olink - Insights from Key Papers ▶ Speaker: Katsuhiko Sasaki (Field Application Scientist, Life Technologies Japan)
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Thermo Fisher Scientific K.K., the Japanese subsidiary of Thermo Fisher Scientific Incorporated, is a sales company for comprehensive system analysis instruments, bio-related equipment, and research reagents. In Japan, it has bases in Yokohama, Tokyo, Osaka, Fukuoka, and Nagoya, handling various analytical instruments including mass spectrometers, various bio-related equipment, measuring instruments, medical devices, lab software, and research reagents.