All-in-One Protein Structure Stability Evaluation System 'UNCLE'
Simultaneous measurement of 12 applications such as thermal stability, sizing, and viscosity from trace samples.
"Uncle" is a product that allows for the acquisition of more data with a small amount of protein. The required sample volume is only 9μL. By combining three different measurement modes—fluorescence, SLS, and DLS—it is easy to evaluate the optimal formulation and the stability of proteins or viral vectors. 【Features】 ■ Measure up to 48 samples in as little as about 2 hours with just 9μL. 【Applications】 ■ Tm & Tagg ■ Tm via SYPRO DSF ■ Isothermal stability ■ Sizing and polydispersity ■ Sizing via thermal gradient ■ Refolding measurements ■ Viscosity ■ kD ■ B22 ■ G22 ■ ΔG ■ Stability of viral capsids *For more details, please refer to the PDF document or feel free to contact us.
basic information
【Specifications (Excerpt)】 ■ Minimum sample volume: 9 μL, sealed capillary ■ Number of simultaneous measurements per experiment: 48 ■ Sample temperature range: 15-95℃ ■ Sample concentration range: 0.05 to 300 mg/mL IgG (depending on the protein) ■ Heating rate: 0.1 to 10℃/min ■ Temperature control accuracy: ±1℃ (<70℃), ±1.5℃ (>70℃) ■ Physical dimensions: Width 54 cm, Depth 50 cm, Height 58 cm, Weight 50 kg *For more details, please refer to the PDF document or feel free to contact us.
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For more details, please refer to the PDF document or feel free to contact us.
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We will exhibit at the Japanese Society of Gene and Cell Therapy Annual Meeting.
Our company will be exhibiting at the 28th Annual Meeting of the Japanese Society of Gene and Cell Therapy, which will be held from Thursday, July 14. At our booth, you can see devices such as the Stunner, which can measure AAV aggregation and Full/Empty ratios in high throughput, and the Uncle, which evaluates thermal stability such as aggregation, as well as videos and materials. We look forward to your visit.
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"Trends in Drug Discovery and Development of Biopharmaceuticals" Limited-Time On-Demand Webinar Now Available!
We will be releasing a recorded video of the presentation from the Jihousha seminar on "Trends in Drug Discovery and Development of Biopharmaceuticals" held in June this year for a limited time! **"New Solutions" for the Evaluation of Physical Properties and Stability of Biopharmaceuticals Provided by Unchained Labs** ■ Overview Antibody-drug conjugates (ADCs) are biopharmaceuticals that have garnered attention due to their pharmacological activity and the excellent specificity of antibodies. However, evaluating their characteristics is very challenging due to the rarity of samples and their tendency to aggregate. In this webinar, we will introduce the platform from Unchained Labs that allows for the quantification, quality assessment, aggregation, conformation, and colloidal stability checks of ADCs and DARs in small amounts and high throughput, making it easy to optimize formulation conditions. ■ Speaker: Yuji Senoo | Field Application Scientist, Unchained Labs, Inc. ■ Availability: Until Tuesday, December 3, 2024 ■ For more details and to watch, click here >> https://go.unchainedlabs.com/l/907652/2024-10-23/zbln1
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[INTERPHEX Online Conference 2024 Gene Therapy Day] November 29 (Friday) Held: Simple, rapid, and highly accurate measurement of viral vectors
In vector development, understanding the ratios of various particles such as titers, Empty/Full, and impurities like aggregates, as well as stability, are essential evaluation criteria. We will introduce analytical methods that can perform these assessments with high precision, quickly, and conveniently using a small sample size, primarily focusing on AAV vectors. ◾️ Details and registration here >> https://eventory.cc/event/interphexonline24/schedule?day=14888 ◾️ Event name: INTERPHEX Online Conference 2024 Gene Therapy Day ◾️ Date and time: November 29 (Friday) 15:30 - 16:00 ◾️ Speaker: Takuma Iwasaki, Field Application Scientist, Unchained Labs, Inc. ◾️ Organized by: INTERPHEX Secretariat 【Pre-registration required, free of charge】 *This seminar is part of the Gene Therapy Day program at the INTERPHEX Online Conference 2024 organized by the INTERPHEX Secretariat.
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We will exhibit at BioJapan 2024.
Our company will be exhibiting at BioJapan 2024, which will be held from Wednesday, October 9. At our booth, we will showcase lipid nanoparticle (LNP) related products, as well as groundbreaking analytical devices for research and development in gene therapy and biopharmaceuticals. We invite you to visit us at Pacifico Yokohama! Exhibition details: ■ Dates: October 9 (Wednesday) - October 11 (Friday), 2024 ■ Venue: Pacifico Yokohama ■ Booth #: D-97
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We will exhibit at the Japanese Society of Gene and Cell Therapy Annual Meeting.
Our company will be exhibiting at the 30th Annual Meeting of the Japanese Society of Gene and Cell Therapy, which will be held from July 16 (Tuesday) to July 18 (Thursday), 2024. At our booth, we will introduce groundbreaking solutions for gene therapy research and development, including the stability evaluation device Stunner and the Leprechaun, which can evaluate the physical properties of lentiviral exosomes. We invite you to visit our booth. Event Name: 30th Annual Meeting of the Japanese Society of Gene and Cell Therapy Date: July 16 (Tuesday) - July 18 (Thursday) Venue: Pacifico Yokohama Conference Center Booth: #18 Details: https://square.umin.ac.jp/jsgct2024/
