Unchained Labs (アンチェインドラブズ） Official site

Our company will be exhibiting at LADEC 2025 (Laboratory Automation Developers Conference). At our booth, you can see the automation equipment in operation. Please come visit us. Dates: September 25 (Thursday) - 26 (Friday), 2025 Venue: National Museum of Emerging Science and Innovation Details: https://laboratoryautomation.connpass.com/event/333560/

The development of lipid nanoparticles (LNPs) requires flexible tools that can consistently handle everything from screening to GMP manufacturing. An ideal manufacturing tool must accommodate small-scale, user-friendly experiments as well as multi-parameter, multi-sample, and even large-scale continuous operations. However, the creation of lipid nanoparticles (LNPs) is only half the goal; evaluating characteristics such as encapsulation efficiency (EE%), payload quantification, particle size, and PDI is also essential. Our Sunshine series and Stunner AF (Add Fluorescence) enable scalable nanoparticle manufacturing and powerful all-in-one characterization. In this webinar, we will introduce scalable LNP manufacturing with Sunshine and one-stop measurements of EE%, total RNA quantification, particle size, PDI, and particle concentration with Stunner AF. Experience solutions that will take nanoparticle development to the next level, from research to industrial applications.

The SMPD division of Takeda Pharmaceutical Company has significantly evolved its high-throughput experimentation (HTE) and automation capabilities over the past few years. At the core of this evolution are the tools and devices from Unchained Labs, which offer high compatibility and enable an integrated comprehensive solution. Our ultimate goal is to build Self-Driving Labs (SDLs) that execute self-optimizing workflows utilizing AI and algorithms. Extensive parameter exploration is essential for process development and optimization, and iterative, data-driven SDLs demonstrate their true value, especially when combined with automated HTE synthesis platforms. In this webinar, we will present a vision for the future of fully automated optimization HTE workflows that can accommodate various applications in synthetic molecular pharmaceutical development. Additionally, we will delve into current success stories of existing hardware and software, as well as the challenges we face at this point through real-world examples.

We have launched a new product. Please check the link below for details.

**[Challenge]** Even with high-purity samples like cell culture samples, accurately characterizing extracellular vesicles (EVs) is not easy. Interference from lipoproteins, cellular debris, and protein aggregates poses challenges. Additionally, the complexity of biological fluids, limited sample volumes, and the presence of rare EV subpopulations further complicate the analysis. **[Solution]** Our Leprechaun separates EVs on Luni consumables, allowing for the measurement of particle size and concentration, and simultaneous analysis of up to four surface or internal markers. It can be applied to samples of less than 25µL, does not require sample purification, and offers sensitivity up to 5×10⁵ particles/mL, single particle analysis, and EV size measurement down to 35nm. **[Demonstration]** In this webinar, we will introduce how Leprechaun combines single particle interference measurement with immunofluorescence imaging to achieve comprehensive analysis of any EV sample. It is also possible to confirm the loading efficiency of cargo carried by EVs, distinguish whether proteins are soluble or EV-derived, and obtain a breakdown of all EV subpopulations.