Lipid nanoparticle automatic synthesis system Sunshine
Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.
Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen
basic information
Throughput: 10 samples in 15 minutes Total flow rate range: 0.1 to 30 mL/min (depending on the chip) Flow ratio (water to organic) range: 1:1 to 10:1 Standard sample volume range (when FRR is 3:1): 1 to 6.5 mL Minimum input volume (including dead volume): 320 μL Continuous mode capacity range: 20 mL to infinity in continuous mode Inline dilution: Yes Standard particle size range: 40 to 200 nm* PDI: Less than 0.2* Encapsulation efficiency: Over 90%*
Price range
Delivery Time
Model number/Brand name
Lipid nanoparticle automatic synthesis system Sunshine
Applications/Examples of results
High-throughput screening LNP Drug delivery Gene therapy
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[Free Webinar] Revolutionizing LNP Development: Smooth Technology Transfer for High-Speed and High-Precision Formulation Exploration and Manufacturing
**[Issue]** The evolution of LNPs is progressing more rapidly than ever, largely due to modifications in particle formulations. However, the formulations to be tested are complex in composition and involve a vast number of combinations, making large-scale screening difficult to achieve. Furthermore, there is the subsequent challenge of transferring to production. Evaluations are also required to be accurate, comprehensive, and high-throughput. **[Webinar Overview]** In this webinar, we will explain how our Sun series can accelerate the exploration and development of LNPs, based on the latest research findings and user case studies in LNP formulations. We will also introduce Stunner, which enables high-speed and accurate LNP evaluations.
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We will exhibit at the DDS Society academic conference.
Unchained Labs, Inc. will exhibit at the 41st Annual Meeting of the Japanese DDS Society, which will be held from June 17 (Tuesday). At our booth, you can see a wide range of products, from the manufacturing of lipid nanoparticles (LNP) to their characterization, as well as products for ADC and the evaluation of extracellular vesicles. Additionally, on the first day of the event, July 17, we will also hold a presentation by exhibiting companies. All of our staff sincerely look forward to your visit. Event Name: 41st Annual Meeting of the Japanese DDS Society Date: July 17 (Tuesday) - July 18 (Wednesday) Venue: Makuhari Messe International Conference Hall Details: https://procomu.jp/dds2025/ <Exhibiting Company Presentation> July 17 (Tuesday) around 15:28
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CPhI Japan Exhibition & Seminar!
CPhI Japan Exhibition & Seminar! April 9 (Wednesday) - 11 (Friday) @ Tokyo Big Sight Unchained Labs, Inc. will be exhibiting in the biopharmaceutical zone at CPhI Japan this year as well. Additionally, we will hold a seminar on the second day! Please visit our booth at Tokyo Big Sight. <Exhibitor Seminar> Date and Time: April 10 (Thursday) 13:00-13:30 Venue: 5B "Stability Evaluation of Biopharmaceuticals - Towards a New Era of High-Speed and High-Throughput" *No prior reservation required, free of charge.
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[Free Webinar] A Bright Future for LNP Formulations Brought by the Sun Platform
Researchers of lipid nanoparticles (LNPs) spend a tremendous amount of time on screening, optimization, and scaling up experiments to achieve optimal performance, spot-on targeting, and controlled release of active pharmaceutical ingredients (APIs). Factors such as solubility, pH stability, payload release, and encapsulation all depend on particle size, shape, and structure. In other words, to obtain the correct formulation, it is necessary to explore a vast number of formulation parameters and process parameters one by one, but even if a perfect formulation is found, scaling up usually means switching equipment and re-optimizing settings. In this webinar, we will introduce Sunny Suite, an automated high-throughput screening platform designed to reduce the time spent on screening, optimizing, and scaling up experiments for LNP formulations.
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◆On-Demand Webinar Distribution◆Rapid and Comprehensive Characterization of Lipid Nanoparticles through Technological Innovation
The concentration of lipid nanoparticles is an important parameter that should be known for all batches of particles, but existing methods either cannot handle throughput, require dilutions that affect accuracy, or take a lot of time. Additionally, keeping the particles at the appropriate size is a common goal, but it is difficult to detect all aggregates in the sample, and collecting size data for all samples is quite challenging. Regarding payload quantification, most solutions rely on complex interrupted workflows, expensive dyes, and wasteful standard curves. In this webinar, you will learn how our newly updated Stunner can perform not only size determination and concentration quantification of LNPs but also payload quantification, providing unique information from various nanoparticle applications. *This webinar is a Japanese translation and presentation of the content "Stop guessing. Get fast LNP quant and sizing on Stunner," composed by Nelis Denys, M.Sc., Market Manager at Unchained Labs, Inc.*
