Allegro STR Single-Use Bioreactor
Single-use lower agitation type bioreactor. Suitable for suspension cell culture applications. High stirring capability! Safe at a total height of under 3m even for 2,000L.
The Allegro(TM) STR single-use bioreactor achieves high mixing capabilities and a low overall height of less than 3 meters, even with a capacity of 2,000 L, thanks to its rectangular culture vessel, which surpasses the performance of traditional cylindrical culture vessels. ■ High Mixing Capability The effective baffle effect of the rectangular culture vessel and the elephant ear-shaped mixing blades allow for the desired oxygen transfer rate to be achieved at lower stirring speeds than before. This results in high kLa and P/V values, reducing shear stress on cells during cultivation at lower stirring speeds. ■ Geometric Similarity Across All Scales, Including Mixing Blades Maintains a similar shape across all scales of 50, 200 L, 500 L, 1,000 L, and 2,000 L. ■ Scalable with Constant P/V Due to geometric similarity and the ability to achieve high P/V values, scaling up with constant P/V is possible. ■ Overall Height Below 3 M Even at 2,000 L Significantly reduces the need for high-altitude work, ensuring the safety of operators. ■ Easy Installation of Dedicated Culture Bags After transporting the single-use culture bag into the culture vessel, it can be set up within 30 minutes with minimal operator intervention.
basic information
【Lineup】50 L, 200 L, 500 L, 1,000 L, 2,000 L 【Stirring Method】Lower stirring by an elephant ear type direct drive impeller 【Maximum kLa】40 /h 【Stirring Performance】Time required to achieve uniformity in the tank is less than 30 seconds at each scale 【Scalability of Cell Proliferation】Scalability data available from bench-top jar fermenters (CHO cells) *For each data point, please download the PDF or contact us for more details.
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Model number/Brand name
Allegro(TM) STR Single-Use Bioreactor
Applications/Examples of results
【Examples of Use】 ■ Production of viral vectors for gene therapy and vaccines using suspension cell culture with HEK293 cells, etc. ■ Production of baculoviruses for gene therapy using insect cell culture with Sf9 cells, etc. ■ Production of monoclonal antibodies using suspension cell culture with CHO cells, etc. ■ Production of viral vectors for gene therapy and vaccines using adherent cell culture with VERO cells on microcarriers, etc.
