In the early stages of drug discovery, the processes of design, manufacturing, testing, and analysis (DMTA) require efficient sample management. Efficient sample storage and tracking, low-volume dispensing of assay-ready plates, workflows for analysis, and automation are necessary. However, accurate and efficient sample management demands significant costs and infrastructure, particularly requiring automation and IT support, which often leads small biotechnology companies to rely on external contract research organizations. In this webinar, the Artios Pharma team will showcase practical examples of an automated end-to-end workflow for sample management using Titian Sample Bank software and SPT Labtech's automation systems. * Up to 40% reduction in data entry cycle time * Reduction in operational costs * Ensuring supply and tracking of clinical samples, enabling rapid data reporting to facilitate decision-making How integrated automated workflows have streamlined the DMTA cycle How to implement an in-house compound management system as an alternative to outsourcing Benefits of automated workflows, such as improved data integrity and expedited decision-making

In this webinar, we will present successful cases of automating long-read whole genome library preparation using the PacBio SMRTbell Long Read Library Preparation Kit 3.0 (SPK3). This automated workflow, conducted on the SPT Labtech firefly platform, provides high-quality sequencing results while maintaining DNA integrity as an alternative to manual processes, creating long-read libraries from eight species, including humans, mice, and crickets. This research contributes to the "Darwin Tree of Life Project," which aims to generate reference genomes for approximately 70,000 eukaryotic species in the British Isles. Automation improves the efficiency and standardization of library preparation, reducing manual labor and errors. This is an opportunity to learn about maintaining DNA integrity and applying it to diverse organisms using the PacBio SMRTbell kit. Lesley Shirley and Ben Farr from the Wellcome Sanger Institute will participate in the Q&A session to answer your questions.

- Screening of tuberculosis treatment drugs using the latest automation technology - Identification of promising enzyme inhibitors through the evaluation of 6,000 compounds - Confirmation of the effectiveness of automation systems in streamlining the drug discovery process - Contribution to the development of new treatment methods for drug-resistant tuberculosis In research aimed at the novel development of tuberculosis treatment drugs, a collaborative study was conducted by SPT Labtech, Automata, GSK, and the Francis Crick Institute. Utilizing the latest automation technology, large-scale screening targeting key metabolic pathways of the tuberculosis bacterium was carried out. In particular, the efficacy, selectivity, and microbiological effectiveness of 6,000 compounds were evaluated. This initiative accelerated the identification of promising enzyme inhibitors and established a foundation for further drug discovery chemistry research. Additionally, important insights were gained regarding the potential integration of robotic platforms in high-throughput drug discovery through improvements in the automated workflow. This research represents a significant step in the development of new treatment methods in response to the increasing challenge of drug-resistant tuberculosis.

In this presentation with MIT.nano, SPT Labtech's cryo-EM development Scientist Michele Darrow discusses using new automation to overcome commonly experienced sample preparation bottlenecks ahead of the microscope.

About this webinar In this webinar presented by Scott Mosser and Christina Minnick – Pharmacology, Assay Operations – Merck, we explore how automation played a pivotal role in achieving their goals. View the on-demand webinar today and:gain insights into how automation increased the capacity and scale of operations

About this webinar This webinar explores how measurement of the kinetics of drug-target interaction can help optimise functional compound properties within this dynamic environment. Using case studies from the CNS and respiratory disease areas, Dr Nick Holliday Chief Scientific Officer (CSO) at Excellerate Bioscience will highlight the benefits of optimising binding on and off rates for duration of action and generation of kinetic selectivity, together with improved inhibitor and antagonist effects.

About this webinar High-throughput genetic screens are an important and widely-used tool in both functional genomics and drug discovery. Our research is focused on developing and applying new technologies to allow larger and more efficient genetic screens to streamline and accelerate the drug discovery process

Creating the optimal workflow is something that any researcher wants, and those focused on NGS are no different. Having the right overall design ensures that you know that your budgets, time and samples are being best used to get the data you need. But the big question is what can you add to your lab that enables you to reach that goal?

Announcement of a webinar for researchers in the pharmaceutical and biotechnology industries, as well as academia, interested in proteomics and multi-omics. Title: "Advanced proteomic biomarker discovery for understanding disease pathophysiology" Speakers: Eric Schordan, PhD and Kamila Koprowska, PhD Overview: How large-scale proteomics data generation, integrating the Olink Explore platform and positive displacement liquid handling technology, provides deep insights into the pathophysiological mechanisms underlying various drugs and diseases, and how it offers a comprehensive reading of protein expression levels in biological samples.

In this webinar, hear how a collaboration between SPT Labtech, Automata, GSK, and researchers at the Francis Crick Institute, employed cutting-edge automation tools, including the dragonfly(R) discovery liquid handling system by SPT Labtech and Automata’s LINQ platform, to conduct a high-throughput enzymatic screen targeting a vulnerable pathway in Mycobacterium tuberculosis (Mtb).

Identifying early markers of transition between human health and disease is a key objective of systems medicine. This strategy requires the collection of diverse longitudinal data from each individual before and after symptoms appear. However, until recently, the comprehensive collection of plasma proteomics has been a barrier to this. In this webinar, we will discuss how high-throughput and high-sensitivity protein profiling, combining Olink technology with SPT Labtech's liquid handling automation technology, has resolved this bottleneck. - The importance of longitudinal deep phenotyping, including plasma proteomics, in systems medicine, complex disease research, and biomarker discovery. - The significance of establishing reference values and ranges for normal human plasma. - How potential prognostic markers for severe and "long" COVID-19 were identified from the plasma proteome. - How adopting the bundled infrastructure of Olink and SPT Labtech enables high throughput and uncompromised data quality in genomics, single-cell, RNA sequencing, and more.

In this webinar recording, entitled “Optimizing automated low volume, high value protein crystallization screening”, distinguished speakers from both academia and industry discuss the benefits of SPT Labtech’s mosquito crystal and mosquito LCP for their crystallization studies/trials.

Access this webinar to discover how our blot-free high-speed approach to vitrification is streamlining the flow of good grids to the microscope whilst capturing essential data to improve the repeatability of cryo-EM samples. We'll share some real world examples of the potential impact on samples with air-water interface issues (preferred orientation, aggregation, denaturation).

In this webinar, scientists from MIT and from the Max Planck Institute of Immunobiology and Epigenetics show how SPT Labtech’s mosquito liquid handlers are enabling high-throughput NGS library preparation and single cell transcriptomics.

About this webinar In early 2020, it was difficult to imagine what would be achieved in laboratories across the globe as the pressure to increase testing capacity and understand the viral lineages of SARS-CoV-2 grew exponentially. Complete the form below to access this 3-part webinar, during which there are presentations from researchers who have transformed their labs, expanded their teams, and implemented automation to show what can be expected for the future of pathogen surveillance.

About this webinar Respective assays range from simple binding analysis to complex phenotypic assays with multiple read-out parameters. In order to understand the molecular mode of action (mMoA) of compounds as early as possible in the drug identification process, Merck also implement mMoA assays, such as competition assays or jump dilution assays into the HTS campaigns.

In this workshop recorded at EMBO Single Cell Biology 2019, Dr. Emilio Yángüez López-Cano from the Functional Genomics Center Zurich discusses the single cell sequencing strategies deployed at his core facility. He explains how they select and combine different single cell RNA-seq approaches, adapting them to the requirements of the research project and the complexity of the samples. Our expert also provides an introduction to our liquid handling instruments and our applications in single cell genomics.

n this webinar, Mike Humphrys describes a novel automated workflow for 16S rRNA sequencing; demonstrating dramatically reduced hands-on time and reagent consumption with miniaturized reaction volumes.

In this on-demand webinar, we explore the various methods of COVID-19 testing: qPCR, COVID-seq, antigen and antibody detection, and others. Coupling these assays with low volume, high speed automation has made great strides toward achieving the high-throughput testing essential to ending the COIVID-19 pandemic.

This webinar highlights development of a single-nucleus RNA-seq2 (snRNA-seq2) method, using the Takara Bio SMART-Seq(R) Single Cell Kit, that allows deep characterization of nuclei isolated from frozen archived tissues, expanding knowledge about cellular heterogeneity.

High-resolution genomic and NGS libraries In this webinar, Richard Eccles from the Centre for Genomic Research at the University of Liverpool alongside SPT Labtech, and New England Biolabs, Inc. demonstrate how the mosquito(R) genomics enables the automation and miniaturization of the NEBNext(R) Ultra(TM) II FS DNA library prep kit, producing high-quality data, increased throughput, and a significant reduction in the cost per sample.

Developing pharmaceutical compounds with improved efficacy and specificity profiles means manipulating small molecules at the nanoscale. Since the structure of a molecule determines its function, approaches that provide access to diverse molecular structures are extremely important. Advances in computational methods and automation have significantly enhanced the ability of medicinal chemists to explore vast chemical spaces and validate novel compounds on a large scale. For example, by integrating virtual screening with high-throughput experiments, scientists can prioritize, validate, and optimize promising candidate compounds repeatedly, thereby shortening the timelines for drug discovery and development. This webinar will explore how automation, particularly low-volume liquid handling, promotes throughput in medicinal chemistry by increasing the number of data points generated for each nanoscale experiment. It will also discuss volumetric technology that enables the precise handling of ultra-small, difficult-to-manage liquids, overcoming reproducibility challenges. Case studies from leading research institutions will showcase how these technologies are successfully driving advancements in science.

Join us at the Olink Proteomics Conference, a novel platform for scientists exploring the latest advancements in proteomics and proteogenomics on immunology, oncology, neuroscience, ageing, inflammation and more applications. The invitation is for a 5-hour event, with 2.5 hours dedicated to live sessions, while other sections like the virtual booth will remain open for the full duration

Exploring the transformation of large-scale proteomic data generation using the Olink Explore platform integrated with positive displacement liquid handling technology. Learn how this combination enables deeper insights into the physiopathologic mechanisms underlying various drugs and diseases by providing a comprehensive readout of protein expression levels in biological samples, demonstrating how robust and precise automation supports high-throughput multiomics research with minimal sample volumes.

In this webinar, hear from Van Andel Institute scientists about how the mosquito HV liquid handler was used to miniaturize and increase throughput of the Takara Bio SMART-Seq Stranded Kit, to yield robust single-cell total RNA libraries from flow-sorted cells, as well as the troubleshooting/optimization challenges and how these were overcome

In this webinar, Spyros Darmanis Ph.D., Cell Atlas Group Leader at the Chan Zuckerberg Biohub, presents a compendium of single-cell transcriptomic data from the model organism Mus musculus - which comprises more than 100,000 cells from 20 organs and tissues.

In this webinar, hear from a team at UC San Diego which employs a highly automated workflow for efficient end-to-end operations from sample collection and accessioning to return of results.

About this webinar Watch this insightful SLAS 2020 workshop recording from Christina Minnick and Liudmila Dzhekieva (Pharmacology, Assay Operations) at Merck: dragonfly discovery dispensing in Drug Discovery.

In this webinar scientists from both SPT Labtech and Takara Bio present: An overview of the SMART-Seq Single Cell Kit and its unique advantages A deep dive tour of the mosquito HV genomics, and its versatility and miniaturization potential Demo and protocol highlights

About this webinar Discover how to build a cost comparison model for automated storage versus manual storage to decide if automation is the right approach for your setting. This webinar considers a wide range of factors to capture all costs associated with an automated sample storage solution versus manual approaches, as well as the benefits to sample quality and ultimately the quality of research. To access the recording simply fill out the form.