For the evaluation of the dissolution properties of active pharmaceutical ingredients! Intrinsic solubility measurement.
USP<1087> Measurement of Intrinsic Solubility by the Intrinsic Dissolution Method
The intrinsic method for dissolution testing provides important information about the active pharmaceutical ingredient by determining the dissolution rate from a test solution with a constant pH, temperature, and surface area. The Biopharmaceutics Classification System (BCS) classifies the characteristics of a drug's solubility and membrane permeability, while the intrinsic method can characterize solubility.
basic information
The dissolution rate is expressed as the mass of the sample that dissolves per unit time in the elution test solution. The sample concentration is plotted against time and surface area as mg/min/cm², and the slope of the line becomes the intrinsic solubility constant. The intrinsic solubility constant also provides information about physical properties, crystallinity, polymorphism, solvation, and more.
Price information
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Price range
P3
Delivery Time
OTHER
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Model number/Brand name
Agilent Intrinsic Dissolution
Applications/Examples of results
Determination of intrinsic solubility
