We are pleased to announce that our company will be exhibiting at COSME Week 2026, the 16th Cosmetics Development Exhibition, which will be held at Tokyo Big Sight for three days starting from January 14, 2026 (Wednesday). In this exhibition, we will introduce ingredients related to the longevity concept that are gaining attention, particularly in Europe, at the skin and cellular levels. We will showcase a variety of attractive ingredients that reflect the latest research trends, so please take this opportunity to visit our booth. We sincerely look forward to your visit.

We exhibited a booth at the "38th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments," held at Pacifico Yokohama from November 1 (Saturday) to November 3 (Monday). Thank you very much to everyone who visited our booth during the event. Please feel free to consult us regarding the exhibited products. We look forward to your continued support. Exhibited products: • Pyrogen test kit for pyrogenic substances • Drug screening & toxicity testing organ-on-a-chip • High-performance culture system (microenvironment culture)

The 42nd Symposium on Formulation and Particle Design was held at Toki Messe (Niigata Convention Center) from October 30 (Thursday) to 31 (Friday), where we exhibited a booth. We sincerely thank everyone who visited our booth during the event. Please feel free to consult us regarding our products. We look forward to your continued support. Exhibited product: BENEO-Palatinit's galenIQ

Thank you very much for visiting our booth at "BioJapan 2025" held recently. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We look forward to your continued support of Higuchi Shokai. Exhibited Products 【Testing Process - Alternatives to Animal Testing】 　Drug Screening & Toxicity Testing Organ-on-a-Chip 　Pyrogen Testing Kit for Testing Pyrogenic Substances 【Cultivation Process - Consumables】 　Cell Culture Bags 　Media Bags 　Sampling & Storage Bottles 　Cryopreservation Bags & Vials 　Filtration Depth Filters for Cultivation 【Next-Generation Technology - Cultivation Equipment】 　High-Performance Cultivation Equipment (Microenvironment Cultivation) 　Automated Cultivation Systems

Thank you very much for visiting our exhibition booth at the 50th Formulation and Creation Seminar "Formulation Technology Q&A Corner" held from September 17 (Wednesday) to 18 (Thursday). If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We look forward to your continued support. ▼Exhibited Products: I Holland manufactured pestles, etc. - Multi-chip pestle - XDF pestle - Rotary head pestle - Alignment tool - TMS (management software) - TSAR (predicts optimal coating)

Thank you very much for visiting our booth at "INCHEM TOKYO 2025," held at Tokyo Big Sight from September 17 (Wednesday) to 19 (Friday). Thanks to your support, we were able to conclude the event successfully with a great deal of interest. We would also like to express our sincere gratitude to everyone who participated in the seminars during the event. If you have any questions or additional requests regarding the products and technologies we introduced, please feel free to contact us. We will respond to the inquiries received during the event in due course. We appreciate your continued support of Higuchi Shokai and look forward to serving you in the future.

We are pleased to announce that we will be exhibiting at BioJapan 2024. At our booth, we will showcase products across the three processes of 'Testing', 'Culturing', and 'Formulation'. In the 'Testing Process', we will introduce "alternative methods to animal testing" such as organ-on-a-chip and monocyte activation tests. In the 'Culturing Process', we will propose various assembly products and depth filters for building manufacturing lines. In the 'Formulation Process', we will present products related to the washing and storage solutions for cell therapies, as well as filling and logistics for final products. We understand that you will be busy during this period, but we sincerely look forward to welcoming many of you, so please feel free to invite others. ◆ Testing Process – Alternative Methods to Animal Testing – - Drug screening & toxicity testing with organ-on-a-chip - Pyrogen testing with MAT kits ◆ Culturing Process – Consumables – - Cell lysis enzyme endonuclease - Cryopreservation bags - Cell culture bags - Media bags - Intermediate product transfer & storage bags - Culturing depth filters ◆ Pharmaceutical Process – Filling & Logistics – - Cell product filling machines - Non-freezing cell storage solutions - Regenerative medicine product logistics boxes & loggers

We are pleased to announce that we will be exhibiting at INCHEM TOKYO 2025. During the event, we will hold the following seminar at the venue. We sincerely look forward to your visit. ◆ Main Exhibits Biar's liquid sampling valve We will demonstrate its installation on a liquid transfer line, so please experience the actual sampling procedure. ◆ Seminar Information 【Safe and Easy Sampling of All Risk Liquids】 Introduction to Inline Liquid Sampling Systems Risk liquids, such as those subject to risk assessment, require minimizing operator exposure during sampling. We will introduce a safe and easy liquid sampling system that does not compromise productivity or workability, using real examples. (1) September 17 (Wed) 15:30 - 16:40, Venue 2 (2) September 19 (Fri) 10:30 - 11:20, Venue 2 *Capacity: 70 people each (Pre-registration required, free admission)

We exhibited at the "9th Bio Pharmaceutical EXPO" held at Tokyo Big Sight from July 9 to 11, 2025! Thank you very much to everyone who visited us. Main Exhibited Products 【Solid Dosage Form Related Products】 Mixer, Torque, Rheometer Tabletop Tablet and Granule Coating Equipment Powder Sampler IVIVC Dissolution Tester BIO-DIS III Functional additives for improving the solubility of poorly soluble drugs Pharmaceutical cleaning agents compatible with cleaning validation Granulated lactose developed for direct compression, spray-dried lactose Tablet press mortar and pestle, reducing compression time by up to 50% Functional ready-to-fill capsules galenIQ Isomalt Hydrate, and others 【Bio Pharmaceutical Related Products】 Single-use Depth Filter Single-use Mixer Bag System Single-use Assembly Bag Culture Bag SafeCell Pyrogen Test Kit (MAT Test Method) instaCELL High-precision Incubator AVATAR ODYSSEY Biomimetic System Organ-on-a-Chip, and others

Thank you very much for visiting our booth at the 52nd Annual Meeting of the Japanese Society of Toxicology held at the Okinawa Convention Center from July 2 to 4, 2025. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We look forward to your continued support of Higuchi Shokai. Exhibited Products: - Heat-generating substance testing kit (MAT testing method) instaCELL - Biomimetic system - Organ-on-a-chip - Culture device (from xcellbio)

Thank you very much for visiting our booth at the "24th Annual Meeting of the Japanese Society for Regenerative Medicine" held at Pacifico Yokohama from March 20 to 22, 2025, during the latest technology introduction corner. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We appreciate your continued support of Higuchi Shokai. Exhibited Products: - Non-freezing cell preservation solution (Cellgentec) - Single-use bags, sterilized capsule filters (Advanced Microdevices) - Assembly tubes, bottles (WHK BioSystems) - Bags for cell freezing preservation and culture (TECHNO FLEX) - Culture devices (xcellbio)

Thank you very much for visiting our booth at the 41st Annual Meeting of the Japanese DDS Society held at Makuhari Messe International Conference Hall from June 17 to 18, 2025. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We look forward to your continued support of Higuchi Shokai. Exhibited Products: - Heat-generating substance testing kit (MAT testing method) instaCELL - Biomimetic system Organ-on-Chip - Single-use assembly bag - Depth filter for harvesting

Our company will be exhibiting at CITE JAPAN 2025, which will be held at Pacifico Yokohama for three days starting from May 14 (Wednesday). We understand that you will be busy during this period, but we sincerely look forward to your visit. SENSOL100 has been nominated for the exhibition award. *Voting is possible from the visitor registration page. Product Introduction SENSOL100 is an upcycled silicone alternative made from paste oil, which is discarded during the refining of avocado oil, using patented technology. The estimated annual global production of avocado oil is approximately 160,000 tons. Green Tech has successfully upcycled the paste oil obtained as a byproduct during the refining process using patented technology for sustainable development. It contains high concentrations of palmitic acid and palmitoleic acid, standardizes all fatty acid compositions, and achieves a silky texture with a low melting point (mp 25°C to 40°C) without quality inconsistencies. It is being increasingly utilized as a silicone alternative. This product has received the "BSB Innovation Award® 2024, 3rd place in the NATURAL PRODUCTS category" and the "in-cosmetics® Korea Silver Award," gaining global attention!

Thank you very much for visiting our booth at the "24th Annual Meeting of the Japanese Society for Regenerative Medicine" held at Pacifico Yokohama from March 20 to 22, 2025, during the latest technology introduction corner. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We look forward to your continued support of Higuchi Shokai. ● Exhibits • Non-freezing cell preservation solution (Cellgentec) • Single-use bags, sterilized capsule filters (Advanced Microdevices) • Assembly tubes, bottles (WHK BioSystems) • Bags for cell freezing preservation and culture (TECHNO FLEX) • Culture devices (xcellbio)

On January 10, 2025, we held an exhibition at the "2nd Academic Symposium of the MPS Practical Promotion Council" at Tower Hall Funabori (Edogawa Ward, Tokyo). Thank you very much to everyone who visited our booth. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products we introduced at the venue, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We appreciate your continued support of Higuchi Shokai. ▼Exhibited Products • Drug Screening & Toxicity Testing Organ-on-a-Chip • Organoid Culture Device

Thank you very much for visiting our booth and participating in the exhibitor seminars at "Chemical Material Japan 2024." Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will also respond to inquiries received during the event in due course. We appreciate your continued support of Higuchi Shokai. ● Exhibits Biar products - Inline liquid sampling valve - Reactor sampling system - REVO cabinet ● Seminar Liquid sampling system designed with operator safety in mind.

We are pleased to announce that we will be exhibiting at the "8th Bio Pharmaceutical EXPO" and the "6th Pharma Lab EXPO Tokyo." At the venue, we will showcase a variety of unique products from both domestic and international sources, including new products. We understand that you may be busy during this period, but we sincerely look forward to welcoming many of you, so please feel free to invite others to join. ● Pharma Lab EXPO Tokyo Booth Number: 54-12 Main Exhibits: - Caleva's tabletop small-scale mixing and extrusion granulator MLS - Agilent's dissolution testing machine BIO-DIS III - Ecolab's cleaning validation compliant detergent for pharmaceutical manufacturing, Pharmaship - Holland's tablet press with a compression time reduction of up to 50%, XDF - GlobePharma's powder sampler - Megre's direct compression granulated lactose Tablettose series, and more ● Bio Pharmaceutical EXPO Booth Number: 45-17 Main Exhibits: - Single-use bags for bioprocessing - Aseptic transfer assembly tubes & bottles - Depth filters for filtration processes - Freezing storage bags, resin vials & syringes, and more

We will be exhibiting at the latest technology introduction corner of the Japanese Society for Regenerative Medicine Annual Meeting. At our booth, we will showcase bioprocess consumables such as filters and assembly bags, as well as cryopreservation bags and vials made from hybrid materials. Please be sure to stop by when you visit.

Our company will be exhibiting at BATTERY JAPAN [Spring] 2024 - the 16th [International] Secondary Battery Exhibition [Spring] - which will be held at Tokyo Big Sight starting from February 28 (Wednesday). At the venue, we will be showcasing products that are optimal for the transportation of battery raw materials. Additionally, during the event, we will hold the following seminar. We invite you to stop by when you visit. ◆ Date and Time: February 28 (Wednesday) 13:30 - 14:00 ◆ Venue: East-L Next Generation Battery Seminar Room Powder Air Transport Equipment: Air transport that doesn't touch the air!? Introducing DEC's powder transport equipment from Switzerland, which allows for "powder raw material supply" - "powder transport from device to device" - "filling" while maintaining an inactive state. We understand that you may be busy during this period, but we sincerely look forward to welcoming many of you, so please feel free to invite others to join you.

We will be exhibiting at the Annual Meeting of the Japanese Society for Molecular Biology / Associated Exhibition. At the venue, we will introduce bioprocess consumables such as filters and assembly tubes. We would be grateful if you could stop by when you visit. <Main Exhibited Products> - Assembly tubes and bags (Advanced Microdevices, WHK BioSystems) - Sterile capsule filters Asepti series (Advanced Microdevices) - Bags for cell freezing and culture (TECHNO FLEX) - SPF chicken eggs for vaccines (avsbio / former Charles River Avian Vaccine Service) - Trypsin for cell detachment (neova) - Vials made from hybrid materials (SiO2)

Thank you very much for visiting our booth and participating in the exhibitor seminars at "INCHEM TOKYO 2023." Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to the inquiries received during the event in due course. We appreciate your continued support of Higuchi Shokai. 【Exhibited Products】 - Powder Transfer System (DEC) - FIBC Discharge Station (DEC) - Liquid Sampling System (BIAR) - Earth Monitoring System (NewsonGale) - Flexible Joint for Powders (Zimmermann)

We are pleased to announce that we will be exhibiting at BioJapan 2023. At the venue, we will showcase bioprocess consumables such as filters and assembly tubes. We understand that you may be busy during this period, but we sincerely look forward to welcoming many of you, along with your colleagues. <Main Exhibited Products> - Sterilizing Capsule Filters Asepti Series (Advanced Microdevices) - Assembly Tubes and Bags (Advanced Microdevices, WHK BioSystems) - Bags for Cell Freezing Preservation (TECHNO FLEX) - Vials made from Hybrid Materials (SiO2)

We will be exhibiting at INCHEM TOKYO 2023, held at Tokyo Big Sight. During the event, we will hold the following seminar (pre-registration required) at the venue, so please make sure to register in advance and stop by when you visit. We sincerely look forward to your attendance. "Work Style Reform through Safe and Secure Closed Systems" Introduction to Powder Handling and Liquid Sampling based on European Cases Recently, it has been said that Japan's labor productivity is low. Our company handles equipment that is used in European chemical plants to "safely improve productivity," and we will introduce it with real examples. September 20, 2023 (Wednesday) 14:40 - 15:30 September 22, 2023 (Friday) 10:40 - 11:30 *The content will be the same for both sessions. 《Main Exhibits》 - Liquid Sampling Valve by BIAR - Earth Monitoring System by Newson Gale

We will be exhibiting at the Japan Society for Bioscience, Biotechnology, and Agrochemistry conference and accompanying exhibition. At the venue, we will introduce bioprocess consumables such as filters and assembly tubes. We would be grateful if you could stop by when you visit. 《Main Exhibits》 - Assembly tubes and bags (Advanced Microdevices, WHK BioSystems) - Sterilizing capsule filters Asepti series (Advanced Microdevices) - Bags for cell freezing and culture (TECHNO FLEX) - SPF chicken eggs for vaccines (avsbio / formerly Charles River Avian Vaccine Service) - Trypsin for cell detachment (neova)

Thank you very much to everyone who visited our booth at "Interfex Week Tokyo - 7th Bio Pharmaceutical EXPO." Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We look forward to your continued support of Higuchi Shokai. 《Main Exhibited Products During the Event》 - Gas-permeable culture bags, cryopreservation bags - Liquid filtration sterilization capsule filters - Single-use assembly tubes - 《vyterial TM》 resin vials/syringes

We are pleased to announce that we will be exhibiting at the 7th Bio Pharmaceutical EXPO. At the venue, we will showcase a variety of unique products from both domestic and international markets, including new products. We understand that you may be busy during this period, but we sincerely look forward to welcoming many of you, along with your colleagues, to our booth.

We are pleased to announce that we will be exhibiting at the 3rd Pharma Lab EXPO Osaka. At the venue, we will showcase a variety of unique products from both domestic and international sources, including new products. We understand that you may be busy during this period, but we sincerely look forward to welcoming many of you, along with your colleagues. 《Main Exhibited Products》 Sterilizing Capsule Filter Asepti Series (Advanced Microdevices) Assembly Tubes and Bags (Advanced Microdevices, WHK BioSystems) 3D Printer for Solid Dosage Form Manufacturing M3DIMAKER (FabRx) Formulation Development Tool Mixer, Torque, Rheometer 3 (Caleva) SEDDS Formulation Starter Kit ABISOL Emulsion Kit (ABITEC) Continuous Liner System, Single-Use Binding Tool (Lugaia), etc.

The globally discussed "inflammaging" in skincare refers to the inflammatory response associated with cellular aging. In this presentation, I will explain the causes, mechanisms, and latest research findings on inflammaging, as well as how bitop's Ectoin(R) natural alleviates it and the mechanisms behind this effect. Additionally, I will present data on the calming effects and repair benefits against inflammation (retinoid) reactions caused by retinol as an application example. <Ectoin(R) natural effectiveness> Anti-aging Wrinkle depth: -32%, flaking occurrence: -76%, roughness: -86%, skin elasticity: +82.4%, brightness improvement: +3%, pigmentation removal: -28%, hair follicles: 80% improvement Anti-pollution effect MMP1 inhibition (MP): -42%, etc. Light protection - Protects against light such as UVA/UVB/BL/IRA Others Long-term moisture retention (7 weeks): +200%, erythema suppression: -38%, barrier function recovery: -28%

We are pleased to announce that we will be exhibiting at BioJapan 2022. At the venue, we will showcase bioprocess consumables such as filters and assembly tubes. We understand that you may be busy during this period, but we sincerely look forward to welcoming many of you, along with your colleagues, to our booth. <Main Exhibited Products> - Sterilizing Capsule Filters Asepti Series (Advanced Microdevices) - Assembly Tubes and Bags (Advanced Microdevices, WHK BioSystems)

At the 47th Formulation and Creation Seminar held at Cross Wave Fuchu from September 8 to 9, we showcased the solid dosage manufacturing 3D printer 'M3DIMAKER' and a tablet press. We sincerely thank everyone who visited our booth during the event. For inquiries regarding the products you saw at the venue, please feel free to contact us at the information below. We will respond to inquiries received during the event in due course. For questions regarding the seminar or other products, we would appreciate it if you could contact our sales representative or reach out to us using the information below. We look forward to your continued support.