Application Note: High Reliability and High Precision Injection of Supercritical Carbon Dioxide Using a Coriolis Flow Controller
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Hot Melt Extrusion (HME) is a method that uses heat and pressure to melt polymers and extrude them into molds in a continuous process. HME is widely applied in the plastics industry and has recently been used in pharmaceutical formulations and drug delivery systems. The HME process is used to mix active pharmaceutical ingredients (APIs) with polymers and other excipients at high temperatures and pressures. The extruded material can be cut or crushed into micro-pellets for filling into capsules or compressing into tablets. Highlights: Measurement and control of mass flow rate of supercritical CO2 Achieving accurate flow rates even at low temperatures (below -30°C) Process Solution: Due to the high reliability of Brooks Instrument's Quantim Coriolis mass flow measurement and control for fluids, systems using this mass flow can measure and control the mass flow rate of the liquid CO2 being injected, rather than the pump's operating speed. In the HME process, when CO2 is maintained above its critical temperature and critical pressure, it enters a supercritical state.
