We will hold a webinar titled "Proposal for Testing Methods Using Standard Material 'Food Allergen Extract' - Application to Cashew Nut Allergen Testing." This time, we are pleased to invite Ms. Eri Inagaki from the Saika Technical Research Institute, a public interest incorporated foundation, to give a lecture on the analysis method using the standard material developed by the foundation with LC-MS/MS. Additionally, we will introduce products related to food allergen testing from our company. We sincerely look forward to your participation. Date and Time: October 23, 2025 (Thursday) 13:00 - 13:50 Title: Proposal for Testing Methods Using Standard Material "Food Allergen Extract" - Application to Cashew Nut Allergen Testing Lecturer: Ms. Eri Inagaki, Saika Technical Research Institute, Public Interest Incorporated Foundation Registration: Please register using the participation application form at the URL below (this will take you to the seminar distribution company's page). Application Period: Until 13:00 on October 23, 2025 * Applications will be closed once the maximum number of participants is reached. * Applications from competitors will not be accepted. * Secondary distribution of the sent URL is prohibited.

We will launch the following products in October 2025. ● General-purpose reagents (5 items) We are reviewing the packaging capacities and consolidating general-purpose reagents of special grade, deer special grade, and deer grade 1 specifications. We will sell new capacities of specifications that are not targeted for consolidation as alternatives to discontinued items. ● Standard materials for environmental analysis (3 items) We will begin handling three standard materials manufactured by LGC Standards for compounds listed in the positive list. ● Shikajenius MRSA-related gene real-time PCR detection kit (1 item) This kit detects MRSA-related genes using a 4-plex real-time PCR. ● Rapid screening reagent for third-generation cephalosporin-resistant bacteria (1 item) This reagent is used to screen Enterobacteriaceae that show resistance to third-generation cephalosporin antibiotics. ● Standard bacterial strains for MALDI TOF-MS quality control (3 items) This product is a set of standard bacterial strains that can be used for quality control of the Bruker MALDI Biotyper. We have prepared sets tailored to specific fields.

We will launch the following new products in September 2025. ● General-purpose Reagents (1 item) We are reviewing the packaging volumes and consolidating products for general-purpose reagents in special grade, deer special grade, and deer grade 1 specifications. Accordingly, we are sequentially informing you of products that will be discontinued as stock runs out, and we will sell new volumes of specifications that are not targeted for consolidation as alternatives to the discontinued items. ● Shikajinius CDToxin Gene Real-time PCR Detection Kit (1 item) We will newly sell a real-time PCR kit for detecting the toxin genes tcdA (toxin A), tcdB (toxin B), and cdtA (binary toxin) of Clostridioides difficile (formerly known as Clostridium difficile). This kit is a 4-plex real-time PCR that simultaneously detects the toxin genes tcdA, tcdB, cdtA of C. difficile and an internal control (IC) to confirm the presence or absence of PCR inhibition.

We will launch the following new product in August 2025. ● Cell Culture Equipment ad-MED Vitrigel Series (1 item) We will newly sell the cell culture equipment "ad-MED Vitrigel Ex (24-well)" using a collagen Vitrigel Ex membrane with high permeability. The collagen Vitrigel membrane has a high-density collagen structure comparable to connective tissue in vivo. This product demonstrates high cell adhesion similar to the conventional ad-MED Vitrigel 2 while improving permeability, making it widely usable for research such as analyzing cell-to-cell interactions through co-culture of different cell types and constructing cell assay systems similar to regular cell culture inserts.

We will launch the following new products in July 2025. ● PFAS Testing Reagents (1 item) We will newly sell "PFAS Testing Methanol," which guarantees extremely low levels of PFAS content, as a result of improvements made to our manufacturing process aimed at reducing PFAS content. ● Standard Products for Environmental Analysis (5 items) We will newly sell mixed standard solutions and internal mixed standard solutions from Wellington Laboratories that comply with PFAS analysis methods in the FDA. ● Food Allergen Testing Kits (2 items) We will newly sell the "Allergen Eye R Immunochromatography Series" food allergen testing kit manufactured by Prima Ham Co., with the measurement item "Cashew Nuts." ● Ionic Liquids (3 items) We will newly sell three ionic liquids that have asymmetric FTA anions. ● High Purity Reagents (4 items) We offer a wide range of high purity reagents guaranteed by the difference method. This time, we have added four halogenated alkyl amines used in the research and development of perovskite solar cells to our lineup.

We will be exhibiting at "BioJapan 2025." We would like to invite you to visit our booth. All of our staff are sincerely looking forward to your visit. ■ Booth Number: D-69 ■ Exhibitor Website https://biojapan2025.jcdbizmatch.jp/Lookup/jp/Member/u0?ke=%E9%96%A2%E6%9D%B1%E5%8C%96%E5%AD%A6&np=2&ob=1&ub=1 ■ Exhibition Content: Manufacturing services for cell culture media and preparation solutions, reagents related to regenerative medicine (such as the ciKIC series), reagents related to cell assays (such as the ad-MED Vitrogel series), etc.

We will launch the following new products in June 2025. ● General-purpose reagents (1 item) We are reviewing the packaging capacities and consolidating products for general-purpose reagents in special grade, deer special grade, and deer grade 1 standards. We will sell new capacities of standard products that are not targeted for consolidation as alternatives to discontinued items. ● Organolithium compounds (2 items) Lithium amide reagents are primarily used as bases for deprotonation applications. Compared to alkyl lithium reagents, lithium amide reagents have lower nucleophilicity, which provides the advantage of suppressing nucleophilic addition of alkyl chains that can be problematic with alkyl lithium reagents. ● Chromagar medium 500 g packaging (2 items) Chromagar has decided to change the product capacity. As a result, we will discontinue some of the current packaging and introduce a new 500 g packaging. ● Precision control for microscopic examination (11 items) We will newly sell the "Microbiology Slide" series of precision controls for microscopic examination manufactured by Microbiologics. This product fixes microorganisms (bacteria, protozoa) on a glass slide and can be used as a precision control for microscopic examination from staining to observation.

We will launch the following new products in May 2025. ● Pesticide Mixed Standard Solution (2 items) This product is a mixed standard solution that corresponds to the "Simultaneous Testing Method for Pesticides, etc. by LC/MS 1 (Agricultural Products) (Appendix 1)." ● Reagents for HPLC We will sell a more user-friendly set of high-purity TFA for HPLC, consisting of 5 bottles of 5mL each. ● Standard Products for Food Analysis (6 items) We will newly sell six food-derived allergen extracts produced by Saika Technical Research Institute. ● Food Allergen Testing Kit We will newly sell the measurement item "Cashew Nut" from the Morinaga Bio Science Research Institute's food allergen testing kit, the NanoTrap Pro2 series. ● Simple Analysis Kit This product has been co-developed with Ajinomoto and allows for the easy measurement of the umami component glutamic acid through simple operations. ● Reagents for Nucleic Acid Synthesis (2 items) The newly sold capping reagents are low moisture guaranteed products that utilize our dehydration technology. ● Growth Factor Substitute Peptides (2 items) Growth factor substitute peptides are expected to demonstrate physiological activity equal to or greater than the existing recombinant protein "KGF (Keratinocyte Growth Factor)" and are anticipated to be used in the proliferation and differentiation of various epithelial cells, such as the epidermis.

We will launch the following new products in April 2025. ● General-purpose reagents (3 items) We are reviewing the packaging capacities and consolidating general-purpose reagents of special grade, deer special grade, and deer first grade standards. Accordingly, we are sequentially informing you of products that will be discontinued as stock runs out, and we will sell new capacities of standard products that are not subject to consolidation as alternatives to the discontinued items. ● High-purity solvent Primepure series (1 item) In the Primepure series, we will newly sell 3L packaging of acetonitrile. The "Primepure" series guarantees the highest purity specifications among commercially available reagents, exceeding existing specifications that are guaranteed by JIS special grade standards and by application. ● Ionic liquids (1 item) We will newly sell DEMEBF4 as our product from the ionic liquids that were sold under a joint label with Nisshinbo Holdings Inc. Ionic liquids are utilized in a wide range of fields such as separation, extraction, reaction solvents, electrochemical devices, tribology, vacuum technology, and bio-related applications, and are expected to be the next-generation solvent.

We will launch the following new products in March 2025. ● Reagents for LC/MS (2 items) In LC/MS analysis, volatile salts such as ammonium acetate and ammonium formate are commonly used as buffer solutions for pH adjustment of the mobile phase. These buffer solutions are also included in analytical methods for pesticide residue analysis in food and official methods such as the Waterworks Law. The newly sold "1 mol/L ammonium acetate solution" and "1 mol/L ammonium formate solution" guarantee "LC/MS testing compatibility," "metal guarantee," and "PFAS testing compatibility," in addition to the existing product guarantees, and implement stricter quality control than products for high-performance liquid chromatography. ● General-purpose reagents We will newly sell the "Sikajenius Vancomycin Resistance Gene Real-Time PCR Detection Kit." This kit uses a 4-plex real-time PCR to simultaneously detect the vanA, vanB, and vanC vancomycin resistance genes, as well as an internal control (IC) to check for PCR inhibition. For more details, please refer to the related links or feel free to contact us.

We will launch the following new products in February 2025. ● Simple Analysis Kit We will newly sell the "Dissolved Oxygen Kit 30" manufactured by Kyoritsu Rika Co., Ltd. The measurement principle of this product is based on the alkaline indigo carmine method, allowing measurements similar to those of conventional products. ● General-purpose Reagents (4 items) We are reviewing the packaging capacities and consolidating products for general-purpose reagents of special grade, deer special grade, and deer grade 1 standards. Accordingly, we are sequentially informing you of products that will be discontinued as supplies run out, but we will sell new capacities of standard products that are not subject to consolidation as alternatives to the discontinued items. ● Quality Control for Gene-related Testing (24 items) Since the outbreak of COVID-19, the importance and necessity of gene-related testing have increased. We will sell quality control products for gene-related testing devices compatible with Microbiologics, including BD MAX, Biofire, Filmarray, Roche Cobas, and Verigene. Please check the list of new products from the related link.

We will launch the following new products in January 2025. ● Reagents for Pharmaceutical Testing We will newly sell "Dilute Hydrochloric Acid" prepared in accordance with "Hydrochloric Acid, Dilute" as described in the Japanese Pharmacopoeia. It is used for testing various pharmaceuticals and herbal medicines in the Japanese Pharmacopoeia. ● Reagents for Nucleic Acid Synthesis We will newly sell "Dichloroacetic Acid" used in the deprotection reaction of the phosphoramidite method. This product guarantees the value of "Trichloroacetaldehyde Monohydrate." ● General-purpose Reagents (5 items) We are reviewing the packaging capacities and consolidating products for special grade, deer special grade, and deer first grade general-purpose reagents. We will sell new capacities of standard products that are not targeted for consolidation as substitutes for discontinued items. ● Acetonitrile/Water/Trifluoroacetic Acid (50:47.5:2.5) We will newly sell a mixed solvent suitable for dissolving matrix reagents and calibration standards used in bacterial analysis by MALDI-TOF MS. ● Nucleic Acid Synthesis 2 mol/L TEAA Solution, pH 7.0 TEAA is widely used as an ion-pair reagent. We have newly prepared a 200 mL packaging. Please check the list of new products from the related link.

Mycoplasma spp. is a type of true bacteria known to cause various diseases such as pneumonia, otitis media, arthritis, and mastitis in production animals like cattle. In this third seminar, titled "Clinical Aspects of Bovine Mycoplasma Infections," we will hear presentations on insights and responses from clinical practice. Date and Time: January 31, 2025 (Friday) 15:30 – 18:00 (scheduled end) [Chair] Professor Hidetaka Iwano, School of Veterinary Medicine, Rakuno Gakuen University Professor Goki Higuchi, School of Veterinary Medicine, Rakuno Gakuen University [Speakers] Dr. Koji Nishi, Monbetsu Livestock Clinic, Okhotsk General Center, Hokkaido Agricultural Mutual Aid Association Dr. Tetsu Obayashi, Shikaoi Livestock Clinic, Tokachi General Center, Hokkaido Agricultural Mutual Aid Association Dr. Kazuhiro Kawai, Laboratory of Veterinary Hygiene, School of Veterinary Medicine, Azabu University Registration: Please register using the participation application form at the URL below. Application Period: December 9, 2024 (Monday) – January 30, 2025 (Thursday)

We will launch the following new products in December 2024. ● Simple Analysis Kit (2 items) We will newly sell a modified version of the "Pack Test Phosphate" manufactured by Kyoritsu Rika Co., Ltd. The current product requires a two-step operation, but the new product will only require a one-step operation of sucking the water sample into a tube. There will be no changes to the measurement principle, measurement range, or standard color types. ● General-purpose Reagents (3 items) We are reviewing the packaging capacity and consolidating product specifications for general-purpose reagents of special grade, deer special grade, and deer grade 1. We will sell new capacities for specifications that are not targeted for consolidation as replacements for discontinued items. ● Cell Dispersion Enzyme (5 items) "Brighterase" is a recombinant enzyme produced using the Brevibacillus expression system, achieving low endotoxin and animal-derived component-free quality. It can be used to isolate cells from biological materials. ● Quality Control for Genetic Testing (5 items) Microbiologics sells quality control products for the GeneXpert genetic testing device sold by Beckman Coulter. Please check the list of new products from the related link.

We will launch the following new products in November 2024. ● Environmental Analysis Standard Products (6 items) We have newly introduced environmental analysis standard products from Analytical Standard Solutions and LGC Standards. The newly added items are standard products for compounds with newly added or changed residue standards. ● General Reagents (6 items) We are reviewing the packaging capacities and consolidating product specifications for general reagents of special grade, deer special grade, and deer grade 1. As a result, we have launched new capacities for specifications that are not subject to consolidation as alternatives to discontinued items. ● Growth Factor Substitute Peptides (2 items) The growth factor substitute peptide "FGF2 substitute peptide" demonstrates physiological activity equal to or greater than that of the existing recombinant protein "FGF2" and shows high stability in culture media, making it expected to be used in the culture of mesenchymal stem cells and iPS cells. ● Cell Culture Media (2 items) This product is an animal-free medium that does not contain human or animal-derived components, suitable for regenerative medicine research, and allows for the proliferation of human mesenchymal stem cells while maintaining their undifferentiated state. Please check the list of new products from the related link.

We will launch the following new products in September 2024. ● AIQS-related reagents (1 item) This product is a reagent for pH adjustment as described in the "Provisional Manual for Screening Analysis Method using AIQS-GC." AIQS (Automated Identification and Quantification Systems) is a screening analysis system developed by a research group led by Professor Kadokami and Associate Professor Miyawaki at Kitakyushu City University. ● Reagents for natural product chemistry research (5 items) We have newly added 5 items centered around the red yeast rice pigment components such as ankaflavin and monascin, which are included in functional foods. Please check the list of new products from the related link.

Mycoplasma spp. is a type of true bacteria known to cause various diseases such as pneumonia, otitis media, arthritis, and mastitis in production animals like cattle. This seminar will focus on bovine respiratory disease, and esteemed speakers will provide necessary information for management, including insights on bovine mycoplasma. Date and Time: January 20, 2023 (Friday) 15:30 - 17:40 (scheduled to end) Chairpersons: Professor Hidetaka Iwano, Faculty of Veterinary Medicine, Rakuno Gakuen University Professor Goki Higuchi, Faculty of Veterinary Medicine, Rakuno Gakuen University Speakers: Dr. Satoshi Gonpei, Faculty of Veterinary Medicine, Rakuno Gakuen University Professor Toshihide Kato, Special Appointment Professor, Rakuno Gakuen University (Microbial Chemistry Research Institute Co., Ltd.) Dr. Tetsuya Goto, Livestock Department, JA Saroma Registration: Please register using the participation application form at the URL below. Application Period: November 11, 2022 (Friday) - January 19, 2023 (Thursday)

We will launch the following new products in February 2022. For details about the products, please contact our branch or sales office. <Analysis Reagent Related Products> ● Drug Simple Detection Kit DRIVEN-FLOW M7-AC We will newly sell the DRIVEN-FLOW M7-AC as part of the DRIVEN-FLOW series of drug simple detection kits. ● Drug Simple Detection Kit: Zolpidem/Zopiclone/Zaleplon Rapid Test We will newly sell a drug simple detection kit that can detect the sleep medications Zolpidem, Zopiclone, and Zaleplon. ● Nitrosamine Standard Products We will newly sell nitrosamine standard products from Dr. Ehrenstorfer and TLC Pharmaceutical Standards.

Mycoplasma spp. is a type of true bacteria, with approximately 120 species reported. In production animals such as cattle, early detection and countermeasures for certain Mycoplasma species are becoming increasingly important. This seminar will focus on bovine mycoplasma, with knowledgeable speakers providing essential information for management. We sincerely look forward to your participation. Date and Time: February 25, 2022 (Friday) 18:00 - 19:30 (scheduled to end) Chair: Professor Hidetaka Iwano, Faculty of Veterinary Medicine, Rakuno Gakuen University Speakers: Professor Goki Higuchi, Faculty of Veterinary Medicine, Rakuno Gakuen University Mr. Masaru Matsumoto, former JA Mashu Lake Dr. Naomi Iwano, COO/Head of Genetic Analysis Division, Japan Animal Special Diagnostics Co., Ltd. Ms. Misaki Kobayashi, Biochemical Division, Kanto Chemical Co., Ltd. Registration: Please register using the participation application form at the URL below. Application Period: December 27, 2021 (Monday) - February 18, 2022 (Friday)

"The Chemical Times" is a periodic publication launched by Kanto Chemical in 1950. It is published four times a year and features research papers on a wide range of fields including chemistry, pharmaceuticals, physics, biology, and more. We have now published issue 263 of "The Chemical Times," which can be accessed via "View Release Source." Additionally, back issues are also available, so please take a look. [Contents] Special Feature: Flow Chemistry ◆ Welcoming the New Year ◆ Reaction Integration Based on Flow Microchemistry ◆ Separation and Purification Technologies for Continuous Flow Processes ◆ Based on Polystyrene-Crosslinked Phosphines ◆ The Fusion of Flow Chemistry and Machine Learning

Mycoplasma spp. is a type of true bacteria, with approximately 120 species reported. In production animals such as cattle, it is important to detect and take measures against certain Mycoplasma species early. This seminar will focus on bovine mycoplasma, and esteemed speakers will provide necessary information for management. We sincerely look forward to your participation. Date and Time: February 25, 2022 (Friday) 18:00 - 19:30 Chair: Dr. Hidetaka Iwano, Faculty of Veterinary Medicine, Rakuno Gakuen University Speakers: Dr. Goki Higuchi, Faculty of Veterinary Medicine, Rakuno Gakuen University Former JA Mashuko, Dr. Yutaka Matsumoto Naomi Iwano, Japan Animal Special Diagnostics Co., Ltd. Misaki Kobayashi, Kanto Chemical Co., Ltd., Biochemical Department Registration: Please register using the participation application form at the URL below https://v2.nex-pro.com/campaign/36975/apply (This will take you to the seminar distribution company's page) Application Period: December 27, 2021 (Monday) - February 18, 2022 (Friday)

We will launch the following new products in December 2021. For details about the products, please contact our branch or sales office. Products related to analytical reagents Daicel Corporation CHIRALPAK IK Series We will newly sell the solvent-resistant chiral columns of the CHIRALPAK IK Series.