Sartorius Stedim Japan K.K. Official site

We will explain the considerations for selecting the optimal filter, including the characteristics of membrane materials and structures, international and domestic regulations, and methods for estimating membrane area through small-scale tests. We will introduce key points for designing efficient and reliable filtration processes. 【Main Learning Content】 ■ Understanding the differences in filter materials and structures, and the selection points suitable for the process ■ Specific learning of methods for calculating membrane area using small-scale tests ■ Key points for filter selection and documentation in accordance with international and domestic regulations 【Seminar Overview】 ▪ Date: February 27 (Friday) from 3 PM (approximately 30 minutes) ▪ Method: Webinar recorded broadcast [Japanese, Free] *We apologize, but participation from individuals not affiliated with the same industry or using email addresses other than those of your organization is not permitted. Thank you for your understanding.

In this exhibition booth, we will introduce the latest solutions to make the final filling process safer and more reliable. The new product Sartopore Evo, launched this year, is a "next-generation filter" designed for the final filtration sterilization process, balancing reduced adsorbent interaction and high flow rates while also considering the increasingly important PFAS compliance. We invite you to experience the evolution of membrane technology that Sartorius has developed over more than 100 years at the venue. Seminar Points: - Introduction of Sartorius' latest filter products and integrity testing equipment that support pharmaceutical manufacturing - Evolution of filter technology from the Sartobran of the 1970s to the latest Sartopore Evo - Integrity testing equipment Sartocheck 5, which fully meets data integrity requirements - Internal cleaning service for integrity testing equipment scheduled to start this winter We hope to provide valuable information for everyone involved in the final filling process, which serves as the last bridge to patients. Date: December 2nd and 3rd (Lunch seminar on the 3rd from 11:50 to 12:50) Venue: Tower Hall Funabori

"Next-Generation CHO Cell Line Development Service Integrating AI and Process Intensification - Innovation of Sartorius CLD Workflow" In biopharmaceutical development, establishing high-quality cell lines in a short period has become increasingly important. Sartorius's Cell Line Development (CLD) service has supported the approval of 7 antibody products and over 80 clinical projects to date. Seminar Points: ■ The latest workflow that selects optimal clones by AI analysis of nano-well images and fluorescence data immediately after single-cell cloning with CellCelector ■ A series of CLD processes that continue from Clone Evaluation, quality analysis, scale-up, to technology transfer to CDMO ■ Process Intensification strategies based on High Inoculation Fed-Batch and Perfusion culture ■ Media optimization service that can be used independently (supporting non-GMP prototypes to GMP manufacturing scale) Date and Time: December 3 (Wednesday) 12:20–13:20 Venue: Omiya Sonic City, Exhibition Hall 2

The Ambr 250 High Throughput is a high-throughput bioreactor that accelerates process development and process characterization analysis. It enables simultaneous cultivation of up to 24 samples while incorporating automated control via a robotic arm and integration with external analytical devices. The culture containers are single-use specifications of 100-250 mL and are compatible with perfusion culture and microcarrier culture. This device has been enhanced based on customer feedback and was launched as the second generation, Ambr 250 High Throughput Generation 2, starting in 2025 to demonstrate further performance as a scale-down model. In this webinar, we will introduce the device overview and the enhanced features in Generation 2. 【Seminar Overview】 ▪ Date: October 16 (Thursday) at 15:00 (approximately 30 minutes) ▪ Method: Webinar recorded broadcast [Japanese, Free] *We apologize, but participation from companies in the same industry and email addresses other than those of your organization is not permitted. Thank you for your understanding.

The final filtration sterilization process in biopharmaceutical manufacturing is a critical process that requires ensuring the efficacy of the product while guaranteeing safety. The PVDF filters commonly used in this process have excellent low adsorption properties, but they contain PFAS, which raises concerns about their impact on the environment and health. Sartorius has addressed this challenge by developing a new filter made from PES material that intentionally does not use PFAS, called "Sartopore Evo." This product significantly reduces protein adsorption compared to conventional PES filters due to its innovative surface treatment technology, achieving low adsorption properties comparable to PVDF filters. Additionally, the excellent liquid flow characteristics of the PES material enable high-flow filtration, contributing to the efficiency of the final filtration sterilization process. In this webinar, we will provide a detailed introduction to the performance and benefits of the new PES filter "Sartopore Evo." 【Seminar Overview】 ▪ Date: November 27 (Thursday) at 3:00 PM (approximately 30 minutes) ▪ Method: Webinar recorded broadcast [Japanese, free of charge] *We apologize, but participation from companies in the same industry and email addresses other than those of your organization is not permitted. Thank you for your understanding.