Ambr15 Cell Culture System Generation 2
Bioreactor system for cell line development and process optimization.
The Ambr1515 Generation 2 is a high-throughput "automated micro-scale bioreactor system" that reproduces the performance of laboratory-scale bioreactors. The system consists of single-use vessels, an automated workstation, and enhanced convenience software. It is designed to be installed in a standard biosafety cabinet for aseptic operations, allowing for parallel monitoring and control of 24 or 48 micro-bioreactor cultures. As the manufacturing processes for biopharmaceuticals become more complex and the density of cultures increases, scientists around the world are facing an unprecedented challenge in developing "clone, medium, and process" that meet new demands. The Ambr15 Generation 2 system enhances equipment performance that influences the success of cultures, improves flexibility, and incorporates new features that reflect user feedback. It helps address the aforementioned challenges and supports the acceleration of research by scientists.
basic information
■ The new features improve the performance of applications such as the following: - Clone selection - Optimization of culture media and feeds - High-density culture processes - Media exchange and passaging in cell therapy applications ■ The new variable deck reduces operator downtime and improves operator efficiency ■ The new Amber clone selection software makes the best clone decision process easier ■ The new Generation 2 liquid handler enables faster and more precise operations, capable of complex tasks such as liquid mixing and addition in multifactorial design of experiments (DoE) ■ Ambr15 is the industry-standard micro-bioreactor system used in research facilities worldwide ■ The addition of metabolite analysis equipment enables a development approach in accordance with Quality by Design (QbD) ■ Ambr15 significantly reduces the amount of culture media and consumables, thereby lowering the cost per experiment, in addition to saving on facility space, funding, and labor ■ Ambr15 contributes to better clone selection on-site, more media selection, and faster process optimization
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Applications/Examples of results
Ambr15 is used as a micro-scale model that resolves various bottlenecks in applications such as the following: - Clone selection - Optimization of media, feeds, and initial processes - Screening under perfusion-like conditions Ambr15 is an industry-standard micro-bioreactor system widely used in the development of biopharmaceuticals such as monoclonal antibodies and recombinant proteins. Ambr15 is increasingly being used to accelerate the development of newer methods such as cell therapy, gene therapy, bispecific antibodies, next-generation vaccines, and antibody-drug conjugates (ADCs).
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Domestic Webinar: CHO Media and Process Development Solutions to Support Optimal Media Selection for Your Cell Line
To maximize the performance of CHO cells, it is necessary to select the optimal medium for each clone and further optimize the process parameters. Sartorius offers a variety of basic media and feeds suitable for Fed-batch culture of major CHO cell lines such as CHO-DG44, K1, S, and GS. In this webinar, we will introduce a case study that combines these CHO media, the automated microbioreactor Ambr15, and the experimental design software MODDE to conduct medium screening and process optimization in a short period. We will also provide information about our Benchmark Study service, which allows you to outsource the selection of the optimal medium and process development for your specific cell line to our research institute in Germany. 【Seminar Overview】 ▪ Date: March 6, 2025 (Thursday) from 3:00 PM (approximately 40 minutes) ▪ Method: Webinar recorded broadcast [Japanese, Free] If you are unable to participate on the day, please register first. We will send you a viewing URL later. *We kindly ask that participants from other companies in the same industry, as well as those using email addresses not affiliated with your organization, refrain from joining. Thank you for your understanding.
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[End] Innovation Forum 2023 "Simplification of pDNA|mRNA Manufacturing Process by Sartorius"
This event has concluded. *Please note that there are currently no plans for on-demand distribution. mRNA pharmaceuticals are attracting attention as a new modality for drug discovery. Sartorius has a wide range of technologies that cover the mRNA manufacturing process, including E. coli culture, pDNA purification, IVT reactions, mRNA purification, and freeze storage. In this forum, we will provide a meaningful discussion platform centered around topics such as "pDNA|mRNA Manufacturing Processes," "Sartorius Manufacturing Platforms," and "Application Examples," inviting guest speakers to give presentations and facilitating questions and interactions from participants. Special Lecture Kazuhisa Uchida, Graduate School, Kobe University Capacity [In-person participation] 35 people *If there are many applications, a lottery will be held. [Online participation] 200 people *Please note that applications from competitors and research companies may be declined in advance.
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[Sending recorded video] Workflow for fully automated cell line development.
Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. The Ambr 15 is an industry-standard microbioreactor system that can perform with 10-15 mL of culture medium in 24 or 48 parallel runs. After culturing, there was a challenge where the number of samples for clarification and simple purification matched the number of specimens, which became a rate-limiting step. However, the next-stage robotic device, StreamLink CC 15, from Ambr has emerged as a breakthrough. This webinar will introduce the advantages of this product, focusing on throughput, in two parts. 【Seminar Overview】 June 1, 2023 (Thursday) from 15:00 (approximately 40 minutes) Webinar recorded broadcast [Japanese, Free] *We sincerely apologize, but participation from companies in the same industry and email addresses other than those of your organization is not permitted. Thank you for your understanding.
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Sending recorded video: What are the equipment requirements needed for the process enhancement challenge?
Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. Since last year, Sartorius has been presenting various proposals and suitable solutions for the challenges of "enhancing processes." In this first webinar of 2022, we will delve deeper than last year's trilogy and discuss several examples regarding cost and equipment considerations. The focus will particularly be on how to manage media that significantly impacts costs and how to design equipment. Please note that this webinar will be presented as the Japanese version of the overseas webinar "Overcoming Facility Constraints Posed by Process Intensification." ▪ Method of holding: Webinar recorded broadcast [Japanese, Free]
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[Sending recorded video] 11/2 [Every Tuesday in Japan] Process Enhancement Series, all 3 sessions - Session 2: High-Throughput Bioreactor Supporting Process Enhancement Efforts
Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. The success or failure of the cultivation process significantly contributes to subsequent productivity, quality, and yield, even within the overall enhanced process. Therefore, the role of process development and optimization for cultivation is positioned as extremely important, and it is necessary to implement these approaches in conjunction with production bioreactors. As the number of considerations increases, there is a demand for cost and labor reduction, and our Amber System is the solution to achieve this. Since 2020, our model capable of perfusion cultivation has received positive feedback, and in the second installment, we will thoroughly convey this feature and its advantages. [Learnable Elements] - Evolved approaches to process development - Advantages of parallel implementation in multi-channel setups [Method of Hosting] Webinar recorded broadcast [Japanese, Free] *Special novelty items will be sent from our company to those who participated in all sessions from the first to the third on the same day.
