HEA and PPA HyperCel resin
Protein separation, mixed-mode chromatography
Mixed-mode resins have the following features: ■ Purification of proteins at low ionic strength by directly capturing hydrophobic sites ■ Separation of complex mixtures due to new ligand selectivity ■ Orthogonal to each step of chromatography, such as ion exchange
basic information
HEA and PPA HyperCel resins are chromatography resins designed for the capture of proteins and the removal of impurities in biopharmaceutical manufacturing environments, and they can be scaled up to industrial levels. The mechanism in "mixed mode" combines electrostatic interactions and hydrophobic interactions between proteins and ligands. The innovative selectivity provided by HEA and PPA HyperCel resins distinguishes them from ion exchange and conventional HIC (hydrophobic interaction chromatography), allowing for simplified process development through screening.
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