Isothermal Titration Calorimeter (Affinity ITC)
Provides high reliability! An excellent tool for measuring a wide range of molecular interactions.
The Isothermal Titration Calorimeter (ITC) is a device that detects the heat changes associated with titration at a constant temperature and is primarily used for analyzing molecular interactions. It measures the minute heat changes that occur when molecules bind to each other, allowing for the determination of binding ratio (n), binding constant (Ka), and the enthalpy change of binding (ΔH) from the resulting titration curve. Affinity ITC is an isothermal titration calorimeter that provides high sensitivity, high reproducibility, and advanced ITC technology in life science research environments. With AccuShot technology, it delivers precise amounts of titrant to the appropriate location, and the FlexSpin stirring function achieves efficient mixing and high sensitivity. The automatic cleaning function prevents contamination between samples. It offers the option of standard capacity (1.0 mL) or low capacity cells (190 µL), and a temperature-controlled auto-sampler for 96 wells is also available.
basic information
■Measurement range: -10°C to 130°C ■Cell capacity: Standard capacity (1.0 mL), low capacity (190 µL) ■Stirring speed: 10 to 1000 rpm ■Temperature control: Solid-state active heating and cooling ■Auto-sampler: 96-well, temperature controlled ■Software: ITCRun, NanoAnalyze ■Cleaning function: Automatic cleaning, user-selectable system cleaning routine
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Model number/Brand name
Affinity ITC
Applications/Examples of results
Applications: ◆ Measurement of intermolecular interactions ◆ Analysis of drug-receptor interactions ◆ Analysis of macromolecules ◆ Binding analysis ◆ Error reduction in biopharmaceutical development Examples of achievements: ◇ Characterization of serotypes and drug loading of AAV and LNP in gene therapy ◇ High-precision measurement of protein-ligand titration ◇ Comparison and evaluation of drug candidates
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News about this product（7）
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April Online LIVE Seminar! ~Protein Analysis Seminar~
13:00～14:00 Examples of ITC Utilization - Useful Information Beyond Binding Strength - Masayuki Oda, Kyoto Prefectural University The Isothermal Titration Calorimeter (ITC) is a device that detects changes in heat associated with titration at a constant temperature, primarily used for analyzing molecular interactions. It provides information not only about binding strengths such as Ka and Kd of biomacromolecules like proteins, but also about binding ratios and thermodynamic quantities (ΔH, ΔS, etc.). This presentation will introduce how these pieces of information can be useful and applied, based on specific examples. 14:00～14:30 Introduction to Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) for Biomacromolecules Minako Maeda, TA Instruments Application Department
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July Online LIVE Seminar! ~Protein Analysis Seminar~
13:00～14:00 Analysis of the interaction between sleep substance-synthesizing enzyme and ligand using isothermal titration calorimetry Shigeru Shimamoto, Lecturer, Department of Life Science, College of Science and Engineering, Kinki University Isothermal titration calorimetry (ITC) has the significant advantage of detecting molecular interactions in a form that is closer to the state present in vivo, without the need for chemical modifications, immobilization, or detection probes. Furthermore, it is a method that provides nearly complete thermodynamic parameters related to the interactions. Here, I will introduce the analysis of the interaction between lipocalin-type prostaglandin D synthase (L-PGDS), which acts as a sleep substance-synthesizing enzyme in the mammalian brain, and its ligand, prostaglandin (PG), using ITC, and discuss the elucidation of the enzyme reaction mechanism in conjunction with structural information. 14:00～14:30 Introduction to isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC) for biomacromolecules Minako Maeda, Applications Department, TA Instruments
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*Application Closed* April Online LIVE Seminar Held! ~Battery Seminar~
On April 2nd (Friday), we will start an online seminar on batteries, inviting Mr. Yoshiyasu Saito from the National Institute of Advanced Industrial Science and Technology, Energy and Environment Division, Energy Conservation Research Department. We hope you find it useful for your research and development of batteries. Additionally, there will be a presentation from our group company, Japan Waters. We look forward to your applications. 【Participation Tool】Zoom *You can also participate via a web browser. (Participation is possible without downloading the Zoom application) Participation fee: Free Please refer to the detailed page for content and application information. We will notify you of the participation details via email one week before the event. Mr. Yoshiyasu Saito, National Institute of Advanced Industrial Science and Technology 【Title】Utilization of Thermal Measurement and Thermal Analysis in Research and Development of Lithium-Ion Batteries Others
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*Application Closed* February Online LIVE Seminar Held! ~Pharmaceutical Seminar~
★ Announcement of Online Seminar on Pharmaceuticals to be Held on February 10 ★ On February 10, we will hold a seminar on the analysis and evaluation of pharmaceuticals, featuring Dr. Kawakami from the National Institute for Materials Science (Group Leader/Chief Researcher of the Medical Application Soft Matter Group, also a Professor in the Graduate School of Pure and Applied Sciences at Tsukuba University). Additionally, there will be a presentation from our group company, Waters Japan. We look forward to your applications. 【Participation Tool】Zoom *You can also participate via a web browser. (Participation is possible without downloading the Zoom application) Participation Fee: Free Please refer to the detailed page for content and application information. We will notify you of the participation details via email one week before the event. Dr. Wataru Kawakami, National Institute for Materials Science [Title] Thermal Analysis Equipment as a Research Tool for Pharmaceuticals: Advanced Utilization Beyond Mere Evaluation Methods Others
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*Application Closed* July Online LIVE Seminar Held! ~Protein Analysis~
★ Online Seminar on Protein Calorimetry & Antibody Engineering ★ We will be holding an online seminar on "Antibody Engineering." We are pleased to welcome Dr. Nagamori from the University of Tokyo's Institute of Medical Science, who will present cutting-edge information on protein calorimetry and antibody engineering research. Additionally, we will provide information on instruments such as isothermal titration calorimeters (ITC) and differential scanning calorimeters (DSC) for biomacromolecules, and our group company Waters will introduce HPLC and UPLC technologies specialized for antibody analysis. Please feel free to join from your home or workplace. 【Participation Tool】Zoom *You can also participate via a web browser. (Participation is possible without downloading the Zoom application) Participation Fee: Free *Due to software specifications, there is a limit on the number of participants. Please register early. For details on the content and registration, please refer to the detailed page. We will notify you of the course details via email one week before the event.
