Analysis Case: Evaluation of Cell Metabolism and Drug Efficacy Using Isothermal Calorimeter TAM
This is an introduction to case studies related to cells by a specialist in analysis. This time, we will present measurement examples using thermal analysis equipment that is useful for evaluations involving cells.
Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology, rheometers) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, etc.
basic information
This time, TA Instruments introduces a device called "TAM," which is an isothermal calorimeter. In this article, we will present a case study related to cell culture, specifically evaluating the efficacy of anticancer drugs through the measurement of tumor cell metabolism. ◆ Evaluation of Anticancer Drug Efficacy through Tumor Cell Metabolism Measurement Heat flow (the change in heat per unit time) shows higher values as the metabolism of the cells becomes more active. As the concentration of the anticancer drug increases, the heat flow values over a long period decrease, indicating that the metabolism of the tumor cells is declining. From the measurement results, a dose-response curve can also be created, and the TAM can be used as a rapid bioassay method.
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Applications/Examples of results
It is equipped with excellent features that provide reliable and meaningful results for the characterization and optimization of biofuels. In temperature scan (DSC) mode, the wax appearance temperature (WAT) is clearly visualized, and in isothermal mode, the reaction rate of catalytic reactions in the fuel production process can be observed over time. Among analytical instruments and calorimetry devices, the TAM can evaluate a variety of products including liquids, solids, crystals, polymers, fuels, foods, and batteries. 【Features】 - Highly responsive temperature control, adjustable in the range of 4 to 150 ℃ - Accurate and stable heat flow measurements even over long-term experiments - Up to four calorimeter positions can accommodate a maximum of four calorimeters - Calorimeters are available in various configurations such as size and sensitivity - Up to eight independent accessories can be controlled - New voltage I/O module for independent probe/source interface 【Specifications】 [Thermostat] - Heat medium: Oil - Number of calorimeters: 4 - Temperature range: 4 to 150 ℃ - Accuracy: < ± 0.1 ℃ - Long-term stability: < ± 100 μ ℃/24h - Scan speed: ≤ ± 2 ℃/h
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June event! Webinar on evaluating the thermal characteristics of batteries using a microcalorimeter.
Event Date and Time: June 11, 2024 (Tuesday) You can register for the archived video using the link below! https://pages.waters.com/2024-06-11-WBN-TAJP-BCMSShortWebinar_LP-Registration1.html 1:00 PM - 1:40 PM [Title] Thermal Characteristics of Batteries Observed with a Microcalorimeter [Overview] A microcalorimeter is a device that can measure very small changes in heat with high sensitivity and is widely used to understand the thermal characteristics of substances and chemical reactions. It is also useful in the research and development of battery technology, including the analysis of battery self-discharge and degradation mechanisms, as well as safety evaluations. This presentation will introduce the overview and principles of microcalorimeters, along with application examples focused on batteries. [Speaker] Minako Maeda, Application Department, TA Instruments
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*Application Closed* April Online LIVE Seminar Held! ~Battery Seminar~
On April 2nd (Friday), we will start an online seminar on batteries, inviting Mr. Yoshiyasu Saito from the National Institute of Advanced Industrial Science and Technology, Energy and Environment Division, Energy Conservation Research Department. We hope you find it useful for your research and development of batteries. Additionally, there will be a presentation from our group company, Japan Waters. We look forward to your applications. 【Participation Tool】Zoom *You can also participate via a web browser. (Participation is possible without downloading the Zoom application) Participation fee: Free Please refer to the detailed page for content and application information. We will notify you of the participation details via email one week before the event. Mr. Yoshiyasu Saito, National Institute of Advanced Industrial Science and Technology 【Title】Utilization of Thermal Measurement and Thermal Analysis in Research and Development of Lithium-Ion Batteries Others
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*Application Closed* February Online LIVE Seminar Held! ~Pharmaceutical Seminar~
★ Announcement of Online Seminar on Pharmaceuticals to be Held on February 10 ★ On February 10, we will hold a seminar on the analysis and evaluation of pharmaceuticals, featuring Dr. Kawakami from the National Institute for Materials Science (Group Leader/Chief Researcher of the Medical Application Soft Matter Group, also a Professor in the Graduate School of Pure and Applied Sciences at Tsukuba University). Additionally, there will be a presentation from our group company, Waters Japan. We look forward to your applications. 【Participation Tool】Zoom *You can also participate via a web browser. (Participation is possible without downloading the Zoom application) Participation Fee: Free Please refer to the detailed page for content and application information. We will notify you of the participation details via email one week before the event. Dr. Wataru Kawakami, National Institute for Materials Science [Title] Thermal Analysis Equipment as a Research Tool for Pharmaceuticals: Advanced Utilization Beyond Mere Evaluation Methods Others
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*Application Closed* July Online LIVE Seminar Held! ~Protein Analysis~
★ Online Seminar on Protein Calorimetry & Antibody Engineering ★ We will be holding an online seminar on "Antibody Engineering." We are pleased to welcome Dr. Nagamori from the University of Tokyo's Institute of Medical Science, who will present cutting-edge information on protein calorimetry and antibody engineering research. Additionally, we will provide information on instruments such as isothermal titration calorimeters (ITC) and differential scanning calorimeters (DSC) for biomacromolecules, and our group company Waters will introduce HPLC and UPLC technologies specialized for antibody analysis. Please feel free to join from your home or workplace. 【Participation Tool】Zoom *You can also participate via a web browser. (Participation is possible without downloading the Zoom application) Participation Fee: Free *Due to software specifications, there is a limit on the number of participants. Please register early. For details on the content and registration, please refer to the detailed page. We will notify you of the course details via email one week before the event.
