Analysis case: Evaluation of protein denaturation temperature and Zn2+ effects using NanoDSC.
This is an introduction to a protein analysis case study by a specialist in analysis. This time, we evaluated the changes in denaturation temperature behavior with the addition of Zn2+ using NanoDSC.
Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.
basic information
At TA Instruments, we handle a wide range of equipment including "thermal analysis instruments," "viscoelastic measurement devices and rheometers," "microcalorimeters (for biological and medical fields)," and "fatigue testing machines." This time, we will introduce three types of microcalorimeters, which are very suitable for evaluation in the fields of biology, bio, and pharmaceuticals. ◆Microcalorimeter for Biological Use (NanoDSC) The microcalorimeter for biological use (nano DSC) is the most widely used thermal analysis instrument for the physical property evaluation of a broad range of materials including polymers, pharmaceuticals, food, biological substances, organic compounds, inorganic compounds, and composite materials.
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Applications/Examples of results
Main Evaluation Items ☆ Thermal Analysis / Glass Transition, Crystallization, Thermal Decomposition Weight, Curing Reaction, Expansion Rate, Thermal Conductivity, Shrinkage Rate, Influence of Moisture, etc. ☆ Viscoelastic Measurement (Rheology) / Viscoelasticity, Elastic Modulus, Viscosity, Stress Relaxation, Creep, Master Curve, Residual Strain, Molecular Weight, Molecular Weight Distribution, etc. ☆ Calorimetry / Intermolecular Interactions, Crystallization, Amorphousness, Aggregation/Precipitation, Dispersibility, Solubility, Compatibility, Wettability, Stability, Adsorption, etc.
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April Online LIVE Seminar! ~Protein Analysis Seminar~
13:00～14:00 Examples of ITC Utilization - Useful Information Beyond Binding Strength - Masayuki Oda, Kyoto Prefectural University The Isothermal Titration Calorimeter (ITC) is a device that detects changes in heat associated with titration at a constant temperature, primarily used for analyzing molecular interactions. It provides information not only about binding strengths such as Ka and Kd of biomacromolecules like proteins, but also about binding ratios and thermodynamic quantities (ΔH, ΔS, etc.). This presentation will introduce how these pieces of information can be useful and applied, based on specific examples. 14:00～14:30 Introduction to Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) for Biomacromolecules Minako Maeda, TA Instruments Application Department
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July Online LIVE Seminar! ~Protein Analysis Seminar~
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On April 2nd (Friday), we will start an online seminar on batteries, inviting Mr. Yoshiyasu Saito from the National Institute of Advanced Industrial Science and Technology, Energy and Environment Division, Energy Conservation Research Department. We hope you find it useful for your research and development of batteries. Additionally, there will be a presentation from our group company, Japan Waters. We look forward to your applications. 【Participation Tool】Zoom *You can also participate via a web browser. (Participation is possible without downloading the Zoom application) Participation fee: Free Please refer to the detailed page for content and application information. We will notify you of the participation details via email one week before the event. Mr. Yoshiyasu Saito, National Institute of Advanced Industrial Science and Technology 【Title】Utilization of Thermal Measurement and Thermal Analysis in Research and Development of Lithium-Ion Batteries Others
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*Application Closed* February Online LIVE Seminar Held! ~Pharmaceutical Seminar~
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