Collection of Thermal Analysis Case Studies for Protein Analysis (Calorimeter) ITC DSC
This is an introduction to protein analysis cases and related equipment by analysis specialists. This time, we will cover three devices: ITC, TAM, and NanoDSC!
Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology, rheometers) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, etc.
basic information
At TA Instruments, we handle a wide range of equipment including "thermal analysis instruments," "viscoelastic measurement devices and rheometers," "microcalorimeters (for biological and medical fields)," and "fatigue testing machines." This time, we will introduce three types of devices that are particularly suitable for evaluation in the fields of biology, bio, and pharmaceuticals, known as "microcalorimeters." 【Agenda】 P3~ Introduction to ITC (Isothermal Titration Calorimeter) Evaluation of binding constants of enzymes and inhibitors Kinetic evaluation of enzyme reactions and the effects of inhibitors P6~ Introduction to NanoDSC (Differential Scanning Calorimeter) Case studies on the stability and denaturation behavior of proteins Evaluation of the dependence of protein denaturation temperature on Zn2+ ion concentration P9~ Introduction to TAM (Isothermal Calorimeter) Evaluation of the efficacy of anticancer drugs through metabolic measurements of tumor cells
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Applications/Examples of results
【Applications】 ☆ Thermal analysis / Glass transition, crystallization, thermal decomposition weight, curing reaction, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelasticity measurement (rheology, rheometer) / Viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Calorimetry measurement (calorimeter) / Intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. 【Examples of Achievements】 ■ Aerospace ■ Asphalt ■ Automotive ■ Ceramics ■ Elastomers ■ Electrical ■ Food ■ Personal care ■ Biomedicine ■ Paints and coatings ■ Inks ■ Petroleum products ■ Pharmaceuticals, etc.
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April Online LIVE Seminar! ~Protein Analysis Seminar~
13:00～14:00 Examples of ITC Utilization - Useful Information Beyond Binding Strength - Masayuki Oda, Kyoto Prefectural University The Isothermal Titration Calorimeter (ITC) is a device that detects changes in heat associated with titration at a constant temperature, primarily used for analyzing molecular interactions. It provides information not only about binding strengths such as Ka and Kd of biomacromolecules like proteins, but also about binding ratios and thermodynamic quantities (ΔH, ΔS, etc.). This presentation will introduce how these pieces of information can be useful and applied, based on specific examples. 14:00～14:30 Introduction to Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) for Biomacromolecules Minako Maeda, TA Instruments Application Department
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July Online LIVE Seminar! ~Protein Analysis Seminar~
13:00～14:00 Analysis of the interaction between sleep substance-synthesizing enzyme and ligand using isothermal titration calorimetry Shigeru Shimamoto, Lecturer, Department of Life Science, College of Science and Engineering, Kinki University Isothermal titration calorimetry (ITC) has the significant advantage of detecting molecular interactions in a form that is closer to the state present in vivo, without the need for chemical modifications, immobilization, or detection probes. Furthermore, it is a method that provides nearly complete thermodynamic parameters related to the interactions. Here, I will introduce the analysis of the interaction between lipocalin-type prostaglandin D synthase (L-PGDS), which acts as a sleep substance-synthesizing enzyme in the mammalian brain, and its ligand, prostaglandin (PG), using ITC, and discuss the elucidation of the enzyme reaction mechanism in conjunction with structural information. 14:00～14:30 Introduction to isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC) for biomacromolecules Minako Maeda, Applications Department, TA Instruments
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*Application Closed* April Online LIVE Seminar Held! ~Battery Seminar~
On April 2nd (Friday), we will start an online seminar on batteries, inviting Mr. Yoshiyasu Saito from the National Institute of Advanced Industrial Science and Technology, Energy and Environment Division, Energy Conservation Research Department. We hope you find it useful for your research and development of batteries. Additionally, there will be a presentation from our group company, Japan Waters. We look forward to your applications. 【Participation Tool】Zoom *You can also participate via a web browser. (Participation is possible without downloading the Zoom application) Participation fee: Free Please refer to the detailed page for content and application information. We will notify you of the participation details via email one week before the event. Mr. Yoshiyasu Saito, National Institute of Advanced Industrial Science and Technology 【Title】Utilization of Thermal Measurement and Thermal Analysis in Research and Development of Lithium-Ion Batteries Others
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*Application Closed* February Online LIVE Seminar Held! ~Pharmaceutical Seminar~
★ Announcement of Online Seminar on Pharmaceuticals to be Held on February 10 ★ On February 10, we will hold a seminar on the analysis and evaluation of pharmaceuticals, featuring Dr. Kawakami from the National Institute for Materials Science (Group Leader/Chief Researcher of the Medical Application Soft Matter Group, also a Professor in the Graduate School of Pure and Applied Sciences at Tsukuba University). Additionally, there will be a presentation from our group company, Waters Japan. We look forward to your applications. 【Participation Tool】Zoom *You can also participate via a web browser. (Participation is possible without downloading the Zoom application) Participation Fee: Free Please refer to the detailed page for content and application information. We will notify you of the participation details via email one week before the event. Dr. Wataru Kawakami, National Institute for Materials Science [Title] Thermal Analysis Equipment as a Research Tool for Pharmaceuticals: Advanced Utilization Beyond Mere Evaluation Methods Others
