Realization of acceleration, high sensitivity, and simplification in the analysis of N-type glycan characteristics.

Innovative technology for the characterization of glycoproteins.

■Extraction of glycans from glycoproteins, labeling, and purification can be completed in just three steps in 30 minutes. This dramatically improves the throughput of glycan analysis. ■Thanks to a significant increase in sensitivity, reliable glycan analysis is possible even with trace amounts of glycoproteins. Glycan identification is achievable from as little as 0.1 μg of glycoprotein. ■By combining a fluorescence detector with MS, both quantification and mass information of trace glycans can be obtained simultaneously in a single analysis. This enables reliable and rapid glycan analysis. ■The GlycoWorks HILIC μElution plate allows for easy and rapid purification. No more drying down is necessary. ■Everything needed for glycan extraction, labeling, and purification is packaged together. You can start preparing glycans right away.

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■ The method currently commonly used, which previously took more than a day for glycan preparation, is now completed in 30 minutes: glycan cleavage (15 minutes) + labeling (5 minutes) + purification (10 minutes). ■ The newly developed RapiFluor-MS reagent offers up to 14 times greater sensitivity in fluorescence and up to 1000 times greater sensitivity in MS compared to currently used glycan labeling. ■ The newly developed RapiFluor-MS reagent combines a highly sensitive fluorescent labeling site and an MS labeling site, allowing for the simultaneous acquisition of larger signals in both optical detection and MS detection. ■ The GlycoWorks HILIC μElution plate developed for glycan purification can purify 96 micro-samples in 10 minutes at once. ■ The GlycoWorks RapiFluor-MS N-Glycan kit includes everything needed for glycan cleavage: enzymes and buffers for cleavage, labeling reagents, purification solid-phase plates, and parts for sample collection.