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Extreme environment microorganisms, long-lasting moisture, UV protection, Langerhans cell protection, anti-pollution, anti-aging, fermentation, hair care.

The German company Bitop was the first in the world to develop Ectoin. It produces Ectoin using a patented method (fermentation method) that utilizes the extremophilic microorganism Halomonas elongata. The company's Ectoin is used not only in cosmetics but also in various formulations overseas as OTC pharmaceuticals for atopic dermatitis, including creams, eye drops, nasal sprays, and mouthwashes, and it is a component with established safety and efficacy. We have various data available, so please feel free to contact us.

Achieved 100% purity of 2αGG, the most active isomer of the miraculous resurrection plant, through our unique manufacturing technology. High moisturizing, wound healing, and cell revitalization functions.

The German company Bitop is the first in the world to develop Ectoin. It produces Ectoin using a patented manufacturing method (fermentation method) that utilizes the extremophilic microorganism Halomonas elongata. The company's Ectoin is used not only in cosmetics but also abroad as OTC pharmaceuticals in various formulations such as creams for atopic dermatitis, eye drops, nasal sprays, and mouthwashes, with established safety and efficacy. They hold various data for cosmetics. Bitop's product strategy is "to draw ideas from nature and add science." In addition to Ectoin, they also produce a natural glycerol glucoside, which is the most cell-activating structural isomer derived from the miraculous resurrection plant, synthesized 100% enzymatically.

New hyaluronic acid crosspolymer, refreshing and moist feeling, anti-wrinkle, pore care, pore tightening, moisturizing effect.

Contipro is a biotechnology company located in the Czech Republic. It is a global manufacturer that produces and sells various active ingredients, primarily sodium hyaluronate, in the pharmaceutical and cosmetic fields, supplying to over 60 countries for approximately 30 years. The products are categorized into three groups: sodium hyaluronate, natural polysaccharides, and peptides. Sodium hyaluronate has different grades with a molecular weight distribution ranging from 2.3 million Da to 10,000 Da, and the effectiveness varies due to differences in skin permeability, which has been confirmed by Vivo and Vitro data. Additionally, there is a grade of sodium hyaluronate that has excellent skin permeability, known as hydrolyzed sodium hyaluronate. Regarding derivatives, it has been confirmed through Vivo and Vitro data that sodium hyaluronate possesses not only its inherent properties of moisturizing, barrier function, anti-wrinkle, and soothing effects but also efficacy in skin whitening, sebum secretion regulation, sebum suppression, and improving skin texture. Furthermore, there are products with delivery functions, including unique derivatives that can form polymer micelles to enhance permeability or release water-soluble active ingredients gradually.

We are introducing Contipro's hyaluronic acid derivatives, such as sodium hyaluronate and hydrolyzed sodium hyaluronate, which have unique efficacy.

Hyaluronic acid derivatives are available in four products. ■HyWhite: A product that incorporates linolenic acid into hyaluronic acid, maximizing the whitening effect of alpha-linolenic acid. ■HyWhite: Enhances the stability of linolenic acid through vesicles formed by itself, also improving skin permeability. ■Delcore: A product that incorporates oleic acid, forming polymer micelles of about 100 nm, which can improve the permeability of active ingredients. Additionally, it has been confirmed through Vivo data that Delcore itself has effects such as increasing sebum levels. ■Cross Linked HA: A powder-type cross-linked hyaluronic acid manufactured using a unique patented technology. It not only provides an instant effect against wrinkles but also allows for the controlled release of water-soluble substances like vitamin B3. By controlling the release, the effectiveness of water-soluble active ingredients can be maximized. ■Tenneliderm: A product chemically modified with hexanoic acid. The effectiveness, including anti-inflammatory effects, has been confirmed. *For more details, please download the PDF or feel free to contact us.

Hyaluronic Acid Na for Whitening that Maximizes the Function of Alpha-Linolenic Acid

HyWhite is a product in which low molecular weight sodium hyaluronate, highly permeable to the skin, is partially replaced with alpha-linolenic acid, resulting in a high whitening effect. Alpha-linolenic acid is widely known for its strong melanin production suppression effect, and in in vitro results, it has been confirmed to have a higher suppression effect than kojic acid. On the other hand, it has also been known as a component that is difficult to formulate due to its low skin permeability and instability. This product promotes the absorption of linolenic acid, which has been a conventional issue, by replacing a portion of low molecular weight hyaluronic acid with alpha-linolenic acid, thereby improving stability and maximizing the effects of alpha-linolenic acid. In Vitro: Melanin production: approximately 50% suppression Tyrosinase activity: approximately 40% suppression Proteasome activity: LLVY approximately 140%, LRR approximately 170%, LLE approximately 180% improvement In Vivo: Asia L value: +6.6% ITA value: +40.1% Melanin: -21.3% Number of spots: -5.6% Skin tone uniformity: 6.4% improvement Caucasus ITA: +10.6% Number of spots: -24% Number of pigmented cells: -18.6%

Achieves excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect"! Low molecular weight hyaluronic acid oligosaccharides with excellent permeability.

OligoHyaferre is a hydrolyzed sodium hyaluronate produced by a company in the Czech Republic, known for its excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect." In vitro studies have confirmed its effects of MMP inhibition, TNF-α inhibition, promotion of angiogenesis, and gene expression of HAS2. These effects lead to favorable results in in vivo "anti-wrinkle tests" and "skin barrier function recovery tests."