Cosmetic ingredients Anti-aging hormone crotamine active site peptide Crodessin
Anti-aging peptide,
Krodesin is a nonapeptide (synthetic human nonapeptide-4) that mimics the active site of the anti-aging gene Klotho. The Klotho gene decreases with age and has been proven to have anti-aging effects. The name is derived from Klotho, the goddess in Greek mythology who spins the thread of fate. Klotho can protect the skin from the fate of aging and provide true rejuvenating effects. =In Vitro= Inhibition of insulin signaling (100%) Stimulation of SIRT1 gene expression (45%) Reduction of reactive oxygen species induced by peroxides (-10%) Inhibition of cellular aging Suppression of UV-induced inflammatory cytokine IL6 (-35%) =In Vivo= Anti-wrinkle (-50%) Fig.1 Elasticity (+200%), Pore size (-10%), number (-8%), Dermal papillae (+15%), luster (+20%), Sebum suppression (-10%)
basic information
Krodesin is a nonapeptide (synthetic human nonapeptide-4) that mimics the active site of the anti-aging gene Klotho. The Klotho gene decreases with age and has been proven to have anti-aging effects. Its name is derived from Klotho, the goddess in Greek mythology who spins the thread of fate. Klotho can protect the skin from the fate of aging and provide true rejuvenation effects. =In Vitro= Inhibition of insulin signaling (100%) Stimulation of SIRT1 gene expression (45%) Reduction of reactive oxygen species induced by peroxides (-10%) Inhibition of cellular aging Suppression of UV-induced inflammatory cytokine IL6 (-35%) =In Vivo= Anti-wrinkle (-50%) Fig.1 Elasticity (+200%), Pore size (-10%), number of pores (-8%), Dermal papillae (+15%), luster (+20%), Sebum suppression (-10%)
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Applications/Examples of results
Water-soluble substances Can be dissolved in a formulation containing 50% alcohol (ethyl alcohol, isopropyl alcohol, propylene glycol, butylene glycol) Recommended usage amount: 0.1-1% Stability: Stable below 60°C Stable at pH 5.5-8 Formulations: Day cream, eye cream, night cream, lotion, serum, mask
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