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In recent years, with the emergence of new drugs that have advanced mechanisms of action, particularly biopharmaceuticals, we are facing more sophisticated challenges in the early stages of drug discovery, such as proof of drug concept and high-content screening. For example, in drug concept proof, there is a demand for the visualization of a seamless drug delivery system from tissue sections to the cellular level, as well as intracellular DDS evaluation of biopharmaceuticals at the organelle level. Additionally, in high-content screening, there is a growing focus on using organoids, which are closer to the in vivo environment than traditional flat cultures, requiring highly accurate high-content analysis. Therefore, in this webinar, Leica and Molecular Devices will present the latest imaging solutions to address these challenges. Date and Time: September 22, 2022 (Thursday) 10:00-10:45, 14:00-14:45 (same content for both sessions) Participation Fee: Free Format: Online only (Capacity: 200 participants) Application Deadline: September 21, 2022 (Wednesday)

Basic Knowledge of CSV, Roles of Users and Suppliers, Category Classification, Recent Developments in DI Guidance, Points to Consider in Contracted Operations, Considerations for Managing and Handling Electronic Data, Key Points for CSV and DI Inspections by Regulatory Authorities, Special Seminar with Clear Explanations Based on Extensive Experience!! ◆Instructor Kenichi Ogiwara, Representative of C-Cast Co., Ltd. Currently active after working at Yokogawa Electric Corporation and Nomura Research Institute. ◆Target Audience Individuals involved in CSV and Data Integrity at pharmaceutical companies, medical device manufacturers, suppliers, etc. ◆Prerequisites No specific prior knowledge required. ◆Knowledge to be Acquired 1) Basic knowledge of CSV 2) Role division between users and suppliers in CSV 3) Correct thinking about category classification 4) Recent status of data integrity guidance 5) Japanese authorities' perspective on data integrity 6) Points to consider in contracted operations (labs and manufacturing) 7) Considerations for managing and handling electronic data 8) Key points for inspections of CSV and data integrity by regulatory authorities.

Title 1: Co-culture of Immune Cells and Vascular-like Tissues Using OrganoPlate for Inflammation and Cancer Research Speaker: Yoko Ejiri (General Manager, Mimetas Japan Co., Ltd.) Title 2: Accelerating Research on Viral Infections and Treatments During the COVID-19 Pandemic: Multidimensional Analysis Using High-Content Imaging and Microplate Readers Speaker: Mitsuo Yamaguchi (Product Manager, Drug Discovery and HTS Products, Product Management Department, Molecular Devices Japan Co., Ltd.)

Event Overview Date: May 27, 2020 (Wednesday) Time: 3:00 PM - 4:00 PM (Please register by noon on the day of the event) Participation Fee: Free Location: Online (A URL for the event will be sent to registrants) Registration Method: Please register here. https://www.moleculardevices.co.jp/seminar-info/13507 Presentation 1: Considerations for the Social Implementation of Organ-on-a-Chip Speaker: Dr. Seiichi Ishida (Professor, Department of Applied Life Sciences, Faculty of Bio-Resource and Bio-Science, Sojo University) Presentation 2: Experimental Design Using Organ-on-a-Chip and Its Implementation Process Speaker: Yoko Ejiri (General Manager, Mimetas Japan) Presentation 3: The Challenges of 3D Imaging and Solutions: Know-how for Capturing and Analyzing High-Quality 3D Data Using ImageXpress Micro Confocal Speaker: Mitsuo Yamaguchi (Product Manager, Molecular Devices Japan) The recording of the previous session is available here https://www.moleculardevices.co.jp/contact_mimetas_movie

Training Content On the first day, you will practice basic culture methods using OrganoPlate 2-lane and 3-lane, and you will seed Caco-2 cells in the 3-lane to create tubular structures. On the second day, you will perform a Barrier integrity assay and cell staining using the cultured cells. You will also practice actual image acquisition and analysis techniques using Molecular Devices' ImageXpress Micro Confocal. At the end of the second day, we are also planning a networking event. Culture example: https://mimetas.com/overview-mimetas-applications/perfused-gut-epithelium-tubules Analysis example: https://mimetas.com/page/assays#barrier Benefits You will receive two OrganoPlate 2-lane and 3-lane plates (worth a total of 100,000 yen).