Solving and investigating drug discovery challenges: 'SpiroKit 4'
Exploration of new chemical space is possible! There are also reports of improvements in metabolic stability and ADME.
In general, building blocks in drug discovery chemistry include scaffolds such as piperidine, piperazine, morpholine, and thiomorpholine. "SpiroKit4" employs azaspiro[3.3]heptane derivatives as alternatives to these scaffolds. By replacing the monocyclic heterocyclic portions contained in drug discovery molecules with spiro[3.3]heptane derivatives, it is possible to uniquely adjust the physicochemical and biochemical properties of the drug discovery molecules. These adjustments enable the exploration of new chemical spaces, and there are reports of improvements in metabolic stability and ADME using this method. *For more details, please refer to the PDF materials or feel free to contact us.*
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