Switch to SpiroKit2 sp3 rich.
Solving the unique problems of sp2 carbon! Composed of sp3-rich linkers that can mimic the benzene ring structure.
Aryl amines are commonly used structures in screening libraries, but they tend to generate highly reactive metabolites, which can become problematic in the later stages of drug development. Additionally, many sp2-rich molecules fail to achieve excellent pharmacokinetic properties. To address these specific issues associated with sp2 carbons, "SpiroKit2" has been developed. This kit consists of sp3-rich linkers that can mimic benzene ring structures and includes bicyclo[1.1.1]pentane derivatives and cubane derivatives. By introducing these structures into drug discovery molecules, the proportion of sp3 carbons within the molecule increases, allowing for improved solubility and the adjustment of lipophilicity. Moreover, compared to sp2-rich structures that adopt planar conformations, sp3-rich structures possess three-dimensional chemical space, enabling the adjustment of the stereochemical shape of drug discovery molecules. These changes in physical properties yield positive results for pharmacokinetic characteristics. *For more details, please refer to the PDF document or feel free to contact us.*
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