Imaging mass spectrometry ion source for mass analysis devices

"ESI and MALDI can be used without modification" - a groundbreaking ion source that enables imaging mass spectrometry in addition to conventional analysis.

The Spectroglyph MALDI/ESI injector is a groundbreaking ion source that enables imaging mass spectrometry in addition to conventional analysis when attached to a Thermo Fisher Scientific mass spectrometer. 【Features】 ◆ ESI and MALDI can be used without replacement The ESI ion source is connected orthogonally to the MALDI source, allowing for a change between ESI and MALDI simply by modifying the parameters within the device. ◆ Unique internal structure 1. Translation stage 2. Slide glass mount 3. High pressure ion funnel 4. Inlet capillary housing 5. Slide valve 6. Ion funnel trap 7. Beam expander 8. CCD camera The injector is equipped with a dual ion funnel, which prevents neutral substances from being introduced into the mass spectrometer, resulting in an improved S/N ratio for the samples. Additionally, by reducing the pressure within the chamber (to 6-7 torr), the ionization efficiency of the samples is also increased.

Imaging mass spectrometry ion source for mass analysis devices │ Techno Alpha

basic information

Imaging mass spectrometry is a technique that directly ionizes biomolecules such as proteins from the surface of flat samples, like thinly sliced tissue sections, and measures them using a mass spectrometer. By performing two-dimensional imaging of the signal intensity of any detected ion, it is possible to visualize the distribution of substances on the sample surface. Therefore, by measuring the ions of drugs using mass spectrometry on tissue sections collected and prepared from individuals after drug administration, the distribution of the drug can be visualized, which is expected to be applied as a new tissue distribution testing method in pharmaceutical development. Additionally, a notable feature is that it can analyze the localization of multiple target substance groups from a single slice without the need for antibodies or staining agents in one measurement.