[Free Webinar] Solutions for Accelerating Lipid Nanoparticle (LNP) Development and Seamless Transfer to GMP Production

Unchained Labs (アンチェインドラブズ）

Lipid nanoparticles (LNPs) are used as carriers to deliver active ingredients such as mRNA into cells. However, their development involves many optimization factors in terms of the formulation of components (lipids, payload) and manufacturing conditions. Therefore, optimizing requires a large number of experiments and comparative evaluations, which is considered to be a tremendous effort and time-consuming. In this webinar, we will introduce our solutions that can address this challenge. First, we will explain the Sun series of LNP manufacturing devices, which can seamlessly execute and transition from efficient formulation and manufacturing condition screening to GMP-compliant production. We will also introduce the Stunner analysis device, which provides various information such as LNP size and concentration at high throughput, and the Unagi automatic buffer exchange device, which aids in solvent removal and formulation optimization, further accelerating development.

Date and time Friday, Aug 30, 2024
02:00 PM ～
Capital
Entry fee Free

Related product information

Automatic Synthesis and Screening System for Lipid Nanoparticles Sunscreen
Accelerating formulation optimization for vaccine and pharmaceutical development.

Throughput: Up to 96 formulations within 6 hours Total flow range: 0.1 to 30 mL/min (depending on the tip) Flow ratio (water to organic): 1:1 to 5:1 Standard sample volume range (when FRR is 3:1): 400 µL to 2 mL Minimum input volume (including dead volume): 105 µL Continuous mode capacity range: NA Inline dilution: Yes Standard particle size range: 40 to 200 nm (depending on the formulation) PDI: Less than 0.2 (depending on the formulation) Encapsulation efficiency: Over 90% (depending on the formulation)
Lipid nanoparticle automatic synthesis system Sunshine
Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Throughput: 10 samples in 15 minutes Total flow rate range: 0.1 to 30 mL/min (depending on the chip) Flow ratio (water to organic) range: 1:1 to 10:1 Standard sample volume range (when FRR is 3:1): 1 to 6.5 mL Minimum input volume (including dead volume): 320 μL Continuous mode capacity range: 20 mL to infinity in continuous mode Inline dilution: Yes Standard particle size range: 40 to 200 nm* PDI: Less than 0.2* Encapsulation efficiency: Over 90%*
GMP-compliant lipid nanoparticle automatic synthesis system Sunbather
Accelerating formulation optimization for vaccine and pharmaceutical development.

Throughput: 10 mL/min per channel Total flow rate range: 0.1 to 30 mL/min (depending on configuration) Flow ratio (water to organic) range: 1:1 to 10:1 Standard sample volume range (when FRR is 3:1): 400 µL to 2 mL Inline dilution: Yes Standard particle size range: 40 to 200 nm (depending on formulation) PDI: Less than 0.2 (depending on formulation) Encapsulation efficiency: Over 90% (depending on formulation)
The "Sun Series" that covers the development of lipid nanoparticles from upstream to downstream.
Seamlessly transition from formulation condition screening to scale-up and GMP manufacturing. Accelerate LNP product development.

*Please check the respective product pages or catalog for detailed specifications.
Protein and Nucleic Acid Quality Evaluation Device 'STUNNER'
Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

【Specifications (Excerpt)】 ■Dimensions: Width 37 cm, Depth 54 cm, Height 33 cm, Weight 26 kg ■Electrical Characteristics: Universal input voltage 100–240 V AC, 50–60 Hz ■Computer: Separate computer with Windows 10 ■Connection: USB, TCP/IP (Service) ■Approvals: CE, FCC, CSA ■Regulatory Compliance: Optional 21 CFR Part 11 software package *For more details, please refer to the PDF document or feel free to contact us.
Bench-top fully automatic buffer exchange concentration device "UNAGI"
[Video Available] Are you spending a lot of time and effort on buffer exchange and concentration work? You can streamline the sample preprocessing steps with this device.

For more details, please refer to the PDF document or feel free to contact us.